Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Hubert, Köster"'
Autor:
Stella Bähr, Ryan W. Rue, Carly J. Smith, Jillian F. Evans, Hubert Köster, Vera P. Krymskaya, Dirk Pleimes
Publikováno v:
Biomolecules, Vol 14, Iss 10, p 1236 (2024)
Lymphangioleiomyomatosis (LAM) is a rare genetic lung disease. Unfortunately, treatment with the mTORC1 inhibitor Rapamycin only slows disease progression, and incomplete responses are common. Thus, there remains an urgent need to identify new target
Externí odkaz:
https://doaj.org/article/c90f637d5ed241ea8b8500a37e58a7ee
Autor:
Maria Joosten, Sebastian Ginzel, Christian Blex, Dmitri Schmidt, Michael Gombert, Cai Chen, René Martin Linka, Olivia Gräbner, Anika Hain, Burkhard Hirsch, Anke Sommerfeld, Anke Seegebarth, Uschi Gruber, Corinna Maneck, Langhui Zhang, Katharina Stenin, Henrik Dieks, Michael Sefkow, Carsten Münk, Claudia D. Baldus, Ralf Thiele, Arndt Borkhardt, Michael Hummel, Hubert Köster, Ute Fischer, Mathias Dreger, Volkhard Seitz
Publikováno v:
Molecular Oncology, Vol 10, Iss 8, Pp 1232-1244 (2016)
Histone deacetylase (HDAC) inhibitors such as suberoylanilide hydroxamic acid (SAHA) are not commonly used in clinical practice for treatment of B‐cell lymphomas, although a subset of patients with refractory or relapsed B‐cell lymphoma achieved
Externí odkaz:
https://doaj.org/article/8c0b9682d8d14e8aab687d3b139b6d0e
Publikováno v:
BioTechniques, Vol 23, Iss 4, Pp 710-714 (1997)
A rapid, robust and widely applicable mutation detection scheme not requiring radioactivity or gel-based detection is introduced. It is a single-tube, competitive oligonucleotide single-base extension (COSBE) reaction using a pair of primers with the
Externí odkaz:
https://doaj.org/article/7099992c513442aeb072a3182b1b0c1e
Autor:
Uschi Gruber, Mathias Dreger, Christian Blex, Matthias Hakelberg, Anett Marais, Frederick Gyapon Quast, Friedrich Kroll, Kathrin Bartho, Anna K. Schrey, Hubert Köster, Oliver Popp, Michael Sefkow, Jens Furkert, Ralf Schülein, Jenny Eichhorst, Sylvia Niquet, Simon Michaelis
Publikováno v:
ChemBioChem. 18:1639-1649
Unbiased chemoproteomic profiling of small-molecule interactions with endogenous proteins is important for drug discovery. For meaningful results, all protein classes have to be tractable, including G protein-coupled receptors (GPCRs). These receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7c85a61c9c229a5b5b44adbfcfef7b4
https://doi.org/10.1002/cbic.201700152
https://doi.org/10.1002/cbic.201700152
Autor:
Anika Hain, Volkhard Seitz, Burkhard Hirsch, Uschi Gruber, Arndt Borkhardt, Mathias Dreger, René M. Linka, Olivia Gräbner, Corinna Maneck, Christian Blex, Sebastian Ginzel, Henrik Dieks, Carsten Münk, Claudia D. Baldus, Michael Hummel, Anke Seegebarth, Anke Sommerfeld, Katharina Stenin, Michael Gombert, Michael Sefkow, Maria Joosten, Hubert Köster, Dmitri Schmidt, Ute Fischer, Ralf Thiele, Cai Chen, Langhui Zhang
Publikováno v:
Molecular Oncology. 10:1232-1244
Histone deacetylase (HDAC) inhibitors such as suberoylanilide hydroxamic acid (SAHA) are not commonly used in clinical practice for treatment of B-cell lymphomas, although a subset of patients with refractory or relapsed B-cell lymphoma achieved part
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee822a4c719001cb8a3b5e21fa5066d1
https://doi.org/10.1016/j.molonc.2016.06.001
https://doi.org/10.1016/j.molonc.2016.06.001
Autor:
Christian Dalhoff, Joji Grace Villamor, Hubert Köster, Renier A. L. van der Hoorn, Farnusch Kaschani, Janina Lenger, Thomas Lenz, Norbert Sewald
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:592-596
Matrix metalloproteases (MMPs) are secreted or membrane-bound zinc-containing proteases that play diverse roles in development and immunity in plants and in tissue remodeling in animals. We developed a photoreactive probe based on the MMP inhibitor m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f878a4de364b001405321324da0bdebb
https://doi.org/10.1016/j.bmc.2011.06.068
https://doi.org/10.1016/j.bmc.2011.06.068
Autor:
Yan Luo, Mathias Dreger, Michael Sefkow, Hubert Köster, Christian Blex, Mirko Glinski, Olivia Baessler
Publikováno v:
Molecular & Cellular Proteomics. 8:2843-2856
The profiling of subproteomes from complex mixtures on the basis of small molecule interactions shared by members of protein families or small molecule interaction domains present in a subset of proteins is an increasingly important approach in funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77b3d5926b3875df923989ce3b6c7ac4
https://doi.org/10.1074/mcp.m900110-mcp200
https://doi.org/10.1074/mcp.m900110-mcp200
Autor:
Manfred Westphal, Frank Berthold, Dorothea Zirkel, Dirk van den Boom, Hubert Köster, Manfred Schwab, Sabine Müller, Walter Zumkeller
Publikováno v:
Human Molecular Genetics. 9:757-763
Genomic imprinting is the result of a gamete-specific modification leading to parental origin-specific gene expression in somatic cells of the offspring. Several embryonal tumors show loss of imprinting of genes clustered in human chromosome 11p15.5,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af352392a41d5b3b89eeb738edf9bf1a
https://doi.org/10.1093/hmg/9.5.757
https://doi.org/10.1093/hmg/9.5.757