Hemolytic anemia repressed hepcidin level without hepatocyte iron overload: lesson from Günther disease model

Autor: Sarah Millot, Constance Delaby, Boualem Moulouel, Thibaud Lefebvre, Nathalie Pilard, Nicolas Ducrot, Cécile Ged, Philippe Lettéron, Lucia de Franceschi, Jean Charles Deybach, Carole Beaumont, Laurent Gouya, Hubert De Verneuil, Saïd Lyoumi, Hervé Puy, Zoubida Karim

Publikováno v: Haematologica, Vol 102, Iss 2 (2017)

Hemolysis occurring in hematologic diseases is often associated with an iron loading anemia. This iron overload is the result of a massive outflow of hemoglobin into the bloodstream, but the mechanism of hemoglobin handling has not been fully elucida

Externí odkaz: https://doaj.org/article/aac1a1886b7c4ca28849a86641e56d33

Variable behavior of iPSCs derived from CML patients for response to TKI and hematopoietic differentiation.

Autor: Aurélie Bedel, Jean-Max Pasquet, Eric Lippert, Miguel Taillepierre, Valérie Lagarde, Sandrine Dabernat, Pierre Dubus, Lucie Charaf, François Beliveau, Hubert de Verneuil, Emmanuel Richard, François-Xavier Mahon, François Moreau-Gaudry

Publikováno v: PLoS ONE, Vol 8, Iss 8, p e71596 (2013)

Chronic myeloid leukemia disease (CML) found effective therapy by treating patients with tyrosine kinase inhibitors (TKI), which suppress the BCR-ABL1 oncogene activity. However, the majority of patients achieving remission with TKI still have molecu

Externí odkaz: https://doaj.org/article/20baab42acec45e29178f6ba8784b5bb

Genetic background influences hepcidin response to iron imbalance in a mouse model of hemolytic anemia (Congenital erythropoietic porphyria)

Autor: Emmanuel Richard, Pierre Costet, Said Lyoumi, Cécile Ged, Thibaud Lefebvre, Magalie Lalanne, Hervé Puy, Zoubida Karim, Hubert de Verneuil, François Moreau-Gaudry, Isabelle Lamrissi-Garcia, Jean-Marc Blouin, Sarah Millot, Laurent Gouya

Publikováno v: Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications, Elsevier, 2019, 520 (2), pp.297-303. ⟨10.1016/j.bbrc.2019.09.141⟩

Clinical severity is heterogeneous among patients suffering from congenital erythropoietic porphyria (CEP) suggesting a modulation of the disease (UROS deficiency) by environmental factors and modifier genes. A KI model of CEP due to a missense mutat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010dc36afaeb6d36505f7554a92cdc2c
https://pubmed.ncbi.nlm.nih.gov/31601421

Avis en réponse à la saisine HCB - habilitation agents 2019. Paris, le 4 juillet 2019

Autor: Comité Scientifique Du Haut Conseil Des Biotechnologies, Frédérique Angevin, Claude Bagnis, Avner Bar-Hen, Marie-Anne Barny, Pascal Boireau, Thierry Brévault, Bruno Chauvel, Cécile Collonnier, Denis Couvet, Elie Dassa, Hubert de Verneuil, Barbara Demeneix, Claudine Franche, Philippe Guerche, Joël Guillemain, Guillermina Hernandez Raquet, Jamal Khalife, Bernard Klonjkowski, Marc Lavielle, Valérie Le Corre, François Lefèvre, Olivier Lemaire, Didier Lereclus, Rémy Maximilien, Eliane Meurs, Nadia Naffakh, Didier NEGRE, Jean-Louis Noyer, Sergio Ochatt, Jean-Christophe Pages, Xavier Raynaud, Catherine Regnault-Roger, Michel Renard, Tristan Renault, Patrick Saindrenan, Pascal Simonet, Marie-Bérengère Troadec, Bernard Vaissière, Jean Luc Vilotte

Publikováno v: [0] Haut Conseil des Biotechnologies. 2019, 2 p
[Autre] Haut Conseil des Biotechnologies. 2019, 2 p
HAL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::353577c91e3cb3953e3a5504c7d57eda
https://hal.inrae.fr/hal-03354431/document

Avis en réponse à la saisine HCB - dossier EFSA-GMO-RX-013. Paris, le 30 janvier 2019

Autor: Comité Scientifique Du Haut Conseil Des Biotechnologies, Frédérique Angevin, Claude Bagnis, Avner Bar-Hen, Marie-Anne Barny, Pascal Boireau, Thierry Brévault, Bruno Chauvel, Cécile Collonnier, Denis Couvet, Elie Dassa, Hubert de Verneuil, Barbara Demeneix, Claudine Franche, Philippe Guerche, Joël Guillemain, Guillermina Hernandez Raquet, Jamal Khalife, Bernard Klonjkowski, Marc Lavielle, Valérie Le Corre, François Lefèvre, Olivier Lemaire, Didier Lereclus, Rémy Maximilien, Eliane Meurs, Nadia Naffakh, Didier NEGRE, Jean-Louis Noyer, Sergio Ochatt, Jean-Christophe Pages, Xavier Raynaud, Catherine Regnault-Roger, Michel Renard, Tristan Renault, Patrick Saindrenan, Pascal Simonet, Marie-Bérengère Troadec, Bernard Vaissière, Jean Luc Vilotte

Publikováno v: [0] Haut Conseil des Biotechnologies. 2019
Avis en réponse à la saisine HCB-dossier EFSA-GMO-RX-013. Paris, le 30 janvier 2019(2019)
HAL
[Autre] Haut Conseil des Biotechnologies. 2019

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::bc71e9f387e2decf07b7710822f5b698
https://hal.inrae.fr/hal-02788108/document