Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Huazhou Ying"'
Publikováno v:
Molecules, Vol 22, Iss 1, p 32 (2016)
A series of novel indene-derived retinoic acid receptor α (RARα) agonists have been designed and synthesized. The use of receptor binding, cell proliferation and cell differentiation assays demonstrated that most of these compounds exhibited modera
Externí odkaz:
https://doaj.org/article/bb59ab4dfb6c4181b232050f67cce5dd
Autor:
Xin Xie, Youhong Hu, Xiaowu Dong, Yongzhou Hu, Weihao Zhuang, Jinxin Che, Zheyuan Shen, Zhi-Long Wang, Huazhou Ying
Publikováno v:
ACS Medicinal Chemistry Letters. 12:836-845
CXC chemokine receptors 1 (CXCR1) and 2 (CXCR2) have been demonstrated to have critical roles in cancer metastasis. Because they share high homology sequences, it is still unclear how to design selective CXCR1 or CXCR2 antagonists. Based on a pharmac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4dd39ea3d62181f077eb09c99b9787a0
https://doi.org/10.1021/acsmedchemlett.1c00113
https://doi.org/10.1021/acsmedchemlett.1c00113
Autor:
Hao Zheng, Huazhou Ying, Chen Xin, Jing Chen, Xiaowu Dong, Siyu Wang, Gang Cheng, Jianjun Zhang, Jinxin Che
Publikováno v:
ChemistrySelect. 5:10924-10927
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba9c535f586a34f653472cc061fd18d7
https://doi.org/10.1002/slct.202002605
https://doi.org/10.1002/slct.202002605
Publikováno v:
Tetrahedron Letters. 60:1060-1065
The 2-(2-hydroxyphenyl)-benzothiazole (HBT) fluorophore has attracted considerable attention due to its excited-state intramolecular proton transfer (ESIPT) based emission and its large Stokes shift. However, this fluorophore possesses several disadv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1f9da0e99f487f6e592ac484bf41137
https://doi.org/10.1016/j.tetlet.2019.03.029
https://doi.org/10.1016/j.tetlet.2019.03.029
Autor:
Huazhou Ying, Jinxin Che, Gang Cheng, Jing Chen, Xiaowu Dong, Qing Ye, Jia Li, Qiu Li, Anhui Gao, Yubo Zhou
Publikováno v:
Chemical Physics Letters. 718:38-45
A set of NF-κB-inducing kinase (NIK) inhibitors was used to develop a molecular docking-based QSAR model by using nonlinear regression method. The accuracy of the QSAR model was remarkably improved by integrating the docking scores and key interacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dacf03c101e3871e4330b2fa5f800576
https://doi.org/10.1016/j.cplett.2019.01.031
https://doi.org/10.1016/j.cplett.2019.01.031
Autor:
Jinxin, Che, Zhilong, Wang, Zheyuan, Shen, Weihao, Zhuang, Huazhou, Ying, Yongzhou, Hu, Youhong, Hu, Xin, Xie, Xiaowu, Dong
Publikováno v:
ACS Med Chem Lett
[Image: see text] CXC chemokine receptors 1 (CXCR1) and 2 (CXCR2) have been demonstrated to have critical roles in cancer metastasis. Because they share high homology sequences, it is still unclear how to design selective CXCR1 or CXCR2 antagonists.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::28996c3bb31c8748aeb8da92c7ad79b4
https://pubmed.ncbi.nlm.nih.gov/34055234
https://pubmed.ncbi.nlm.nih.gov/34055234
Background: Medicinal chemistry is one of the most important professional courses for undergraduate pharmacy students. It plays an essential role in the cultivation of innovative pharmaceutical talents, especially for drug discovery and development.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fb702640cf6ad90ec9e66910125579d
https://doi.org/10.21203/rs.3.rs-72179/v1
https://doi.org/10.21203/rs.3.rs-72179/v1
Autor:
Xiaoyun, Chen, Xianmin, Wu, Jian, Gao, Huazhou, Ying, Xiaowu, Dong, Jinxin, Che, Zhijian, Shen
Publikováno v:
Archiv der PharmazieREFERENCES. 354(3)
Isocitrate dehydrogenase 2 (IDH2) is a key enzyme in the regulation of cell metabolism. Its mutated type can lead to the accumulation of 2-hydroxyglutarate, which is often related to malignancies such as acute myeloid leukemia. Therefore, it is neces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c1bd7d9dab74defe6c5c70c6ef9920bd
https://pubmed.ncbi.nlm.nih.gov/33184958
https://pubmed.ncbi.nlm.nih.gov/33184958
Autor:
Huazhou Ying, Lu Yan, Feng Huang, Wen-Wen Nie, Chunqi Hu, Xiaowu Dong, Quan Zhang, Mei-Rong Zhao
Publikováno v:
Chemical Physics Letters. 706:360-366
Endocrine disrupting chemicals (EDCs) can exhibit adverse effects by increasing or blocking hormonal activities as agonists or antagonists through nuclear receptors. Computational toxicology research provides a fast and automated screening tool for d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c91c7541ecd5deb930291c47e358dcc8
https://doi.org/10.1016/j.cplett.2018.06.022
https://doi.org/10.1016/j.cplett.2018.06.022
Publikováno v:
MedChemComm. 8:1835-1844
A set of ninety-eight B-RafV600E inhibitors was used for the development of a molecular docking based QSAR model using linear and non-linear regression models. The integration of docking scores and key interaction profiles significantly improved the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44a5a03f468c04dc1466350dfa536b88
https://doi.org/10.1039/c7md00229g
https://doi.org/10.1039/c7md00229g