Výsledky vyhledávání

PARD3 gene variation as candidate cause of nonsyndromic cleft palate only

Autor: Renjie Cui, Dingli Chen, Na Li, Ming Cai, Teng Wan, Xueqiang Zhang, Meiqin Zhang, Sichen Du, Huayuan Ou, Jianjun Jiao, Nan Jiang, Shuangxia Zhao, Huaidong Song, Xuedong Song, Duan Ma, Jin Zhang, Shouxia Li

Publikováno v: Journal of Cellular and Molecular Medicine. 26:4292-4304

Nonsyndromic cleft palate only (NSCP) is a common congenital malformation worldwide. In this study, we report a three-generation pedigree with NSCP following the autosomal-dominant pattern. Whole-exome sequencing and Sanger sequencing revealed that o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87528db79b9a8742debcce2803c3f119
https://doi.org/10.1111/jcmm.17452

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Delivery of Glucosylceramidase Beta Gene Using AAV9 Vector Therapy as a Treatment Strategy in Mouse Models of Gaucher Disease

Autor: Meiqin Zhang, Jin Zhang, Duan Ma, Nan Jiang, Sichen Du, Jing Ma, Huayuan Ou, Xiaorong Li, Renjie Cui

Publikováno v: Human Gene Therapy. 30:155-167

Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by mutations in the GBA gene. Enzyme replacement treatment is the most effective therapy available for type 1 GD patients, but it is very expensive and does not improve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ab1073914430ca6d4d8794dd1087c8
https://doi.org/10.1089/hum.2018.072

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Deregulated lncRNA expression profile in the mouse lung adenocarcinomas with KRAS-G12D mutation and P53 knockout

Autor: Huayuan Ou, Tinglan Chen, Meiqin Zhang, Nan Jiang, Sichen Du, Renjie Cui, Runsheng Ge, Jin Zhang, Duan Ma

Publikováno v: Journal of Cellular and Molecular Medicine

Recent studies have demonstrated that aberrant long non‐coding RNAs (lncRNAs) expression are suggested to be closely associated with multiple human diseases, lung cancer included. However, the roles of lncRNAs in lung cancer are not well understood

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f6fcefb89858c2084f98c2347b8e3a8
https://pubmed.ncbi.nlm.nih.gov/31410985

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AMOTL2 inhibits JUN Thr239 dephosphorylation by binding PPP2R2A to suppress the proliferation in non-small cell lung cancer cells

Autor: Renjie Cui, Nan Jiang, Runsheng Ge, Duan Ma, Meiqin Zhang, Sichen Du, Jin Zhang, Huayuan Ou

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1868:118858

Protein phosphatase 2A (PP2A) complex comprises an extended family of intracellular protein serine/threonine phosphatases, that participate in different signaling transduction pathways. Different functions of PP2As are determined by the variety of re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852f968e9c40b52138d9f4db30954dfc
https://doi.org/10.1016/j.bbamcr.2020.118858

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