Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Huaxin, Hou"'
Autor:
Honglan Zhai, Chunmiao Wang, Junying Li, Dandan Liang, Fengming Li, Qiuping Zhang, Jingni Wang, Tuo Ma, Danrong Li, Huaxin Hou
Publikováno v:
Future Medicinal Chemistry. 15:129-145
Background: Endoplasmic reticulum (ER) stress is a therapeutic target in cancer given its regulation of bioenergetics and cell death. Methodology & results: We synthesized 14 ER stress-triggered anthraquinone derivatives by introducing an amino group
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1628f5435bf9cbd9145e60371bc0233
https://doi.org/10.4155/fmc-2022-0217
https://doi.org/10.4155/fmc-2022-0217
Rhein Derivative 4F Inhibits the Malignant Phenotype of Breast Cancer by Downregulating Rac1 Protein
Autor:
Xinxiao Li, Yunfeng Liu, Yuhua Zhao, Wei Tian, Lina Zhai, Huifeng Pang, Jiankang Kang, Huaxin Hou, Yanhua Chen, Danrong Li
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
BackgroundTriple-negative breast cancer is a common malignant tumor with unfavorable prognosis affecting women worldwide; thus, there is an urgent need for novel therapeutic drugs with improved anti-tumor activity. Rac family small GTPase 1 (Rac1) pl
Externí odkaz:
https://doaj.org/article/2f9c7128976d47ae9b96609c8273d3a3
Publikováno v:
Journal of Molecular Structure. 1279:134950
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d4c0f7697a36e65ddb0ae0c98e5ae82
https://doi.org/10.1016/j.molstruc.2023.134950
https://doi.org/10.1016/j.molstruc.2023.134950
Publikováno v:
Planta medica. 88(13)
The aim of the present study was to investigate the cytotoxic effects and underlying molecular mechanisms of nitidine chloride (NC) in hepatocellular carcinoma cells via quantitative proteomics. MTT assays were used to detect the inhibitory effects o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcda85e37c6ac784c7b0aa2f7d6f1684
https://pubmed.ncbi.nlm.nih.gov/35104905
https://pubmed.ncbi.nlm.nih.gov/35104905
Autor:
Yanping Zhong, Danrong Li, Huifeng Pang, Yunfeng Liu, Huaxin Hou, Wei Tian, Fu Lan, Jiankang Kang
Publikováno v:
Anti-Cancer Drugs. 30:1038-1047
Triple negative breast cancer (TNBC) has very poor prognosis and no efficacious therapeutic options due to the absence of a validated molecular target. Therefore, novel therapeutic strategies against TNBC are urgently needed. Our team synthesized and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b2aa8b679c0499df80cb1757b54475
https://doi.org/10.1097/cad.0000000000000820
https://doi.org/10.1097/cad.0000000000000820
Autor:
Zhengying Su, Danrong Li, Dandan Liang, Zhaoquan Li, Huaxin Hou, Chunmiao Wang, Wei Tian, Junying Li, Fu Lan
Publikováno v:
ACS Med Chem Lett
[Image: see text] Novel anthraquinone compounds that induce ER stress and paraptosis-like cell death were designed and synthesized. Compound 4a is the first organic micromolecule to kill tumor cells by only paraptosis, and its mechanism of action has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e1ef5929e168124716f81f6d59db8a
https://doi.org/10.1021/acsmedchemlett.8b00624
https://doi.org/10.1021/acsmedchemlett.8b00624
Publikováno v:
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 36(10)
Objective To establish a triple negative breast cancer cell line stably expressing human epidermal growth factor receptor (EGFR) promoter and luciferase (Luc) reporter gene and to preliminarily verify its application. Methods Using genetic recombinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e081c6f777a6052e3d460647e8c7507d
https://pubmed.ncbi.nlm.nih.gov/33148387
https://pubmed.ncbi.nlm.nih.gov/33148387
Autor:
Huaxin Hou, Xinxiao Li, Junying Li, Lina Zhai, Wei Tian, Jiankang Kang, Danrong Li, Yanping Zhong
Publikováno v:
International journal of oncology. 58(5)
At present, effective therapeutic drugs for triple‑negative breast cancer (TNBC) are lacking due to the absence of identified or available targets. Therefore, the present study aimed to identify key molecular targets and a specific targeted therape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a4097e5e6e22b5be464d026c6eb891b
https://pubmed.ncbi.nlm.nih.gov/33760108
https://pubmed.ncbi.nlm.nih.gov/33760108
Publikováno v:
Future Medicinal Chemistry.
Anthraquinones exhibit a unique anticancer activity. Since their discovery, medicinal chemists have made several structural modifications, resulting in the design and synthesis of a large number of novel anthraquinone compounds with different biologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d96e51d64f875415f2771dde5ae89d3
https://doi.org/10.4155/fmc-2019-0322
https://doi.org/10.4155/fmc-2019-0322
Publikováno v:
Journal of Molecular Structure. 1147:462-468
Radiation resistance of nasopharyngeal carcinoma (NPC) is a joint effect caused by complex molecular mechanisms. The development of multi-target radiotherapy sensitization agents offered a promising method for the treatment of NPC. In this work, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cace41d0079045e8de37d6c39bc6f3a9
https://doi.org/10.1016/j.molstruc.2017.06.123
https://doi.org/10.1016/j.molstruc.2017.06.123