Zobrazeno 1 - 10
of 819
pro vyhledávání: '"Huaxi Xu"'
Autor:
Na Wang, Lujian Cai, Xinyu Pei, Zhihao Lin, Lihong Huang, Chensi Liang, Min Wei, Lin Shao, Tiantian Guo, Fang Huang, Hong Luo, Honghua Zheng, Xiao-fen Chen, Lige Leng, Yun-wu Zhang, Xin Wang, Jie Zhang, Kai Guo, Zhanxiang Wang, Hongsheng Zhang, Yingjun Zhao, Huaxi Xu
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110006- (2024)
Summary: Apolipoprotein E (apoE) plays a crucial role in the pathogenesis of Alzheimer’s disease (AD). Microglia exhibit a substantial upregulation of apoE in AD-associated circumstances, despite astrocytes being the primary source of apoE expressi
Externí odkaz:
https://doaj.org/article/e97f06da8e3f498d90bbf7902b2919a8
Autor:
Xin Li, Banglian Hu, Xiaoyan Guan, Ziwei Wang, Yuhang Zhou, Hao Sun, Xian Zhang, Yanfang Li, Xiaohua Huang, Yingjun Zhao, Xin Wang, Huaxi Xu, Yun-Wu Zhang, Zhanxiang Wang, Honghua Zheng
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-18 (2023)
Abstract Background Mutations in colony-stimulating factor 1 receptor (CSF1R) are known to cause adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), which has been recently demonstrated as a primary microgliopathy charact
Externí odkaz:
https://doaj.org/article/59f57c62a5e446e6833d9f2762df993b
Autor:
Wenlong Zhang, Liuyan Ding, Huaqing Chen, Mengran Zhang, Runfang Ma, Shaohui Zheng, Junwei Gong, Zhiling Zhang, Huaxi Xu, Pingyi Xu, Yunlong Zhang
Publikováno v:
Cell Death and Disease, Vol 14, Iss 4, Pp 1-15 (2023)
Abstract Parkinson’s disease (PD) is the most common progressive neurodegenerative movement disorder, which is characterized by dopaminergic (DA) neuron death and the aggregation of neurotoxic α-synuclein. Cntnap4, a risk gene of autism, has been
Externí odkaz:
https://doaj.org/article/8837526eb4d64d928e375fc0f77843e4
Autor:
Seyed Mehdi Vatandoust, Javad Mahmoudi, Shahrbanoo Oryan, Fereshteh Farajdokht, Saeed Sadigh-Eteghad, Siamak Sandoghchian Shotorbani, Huaxi Xu, Delaram Eslimi Esfahani
Publikováno v:
Chinese Journal of Physiology, Vol 66, Iss 4, Pp 209-219 (2023)
Sericin (Ser) is a natural neuroactive macromolecule with diverse pharmacological properties, and our previous findings have shown its neuroprotective potentials. This study aimed to investigate the therapeutic potential of Ser on cognitive dysfuncti
Externí odkaz:
https://doaj.org/article/446c3fa5db1b464fb3739ff62dc0154b
Publikováno v:
Central European Journal of Immunology, Vol 47, Iss 4, Pp 373-381 (2023)
Triggering receptor expressed on myeloid cell-2 (TRE M2) is a transmembrane receptor which is specifically expressed on myeloid cells. To date, TRE M2 has been confirmed as a key factor in many pathologies, such as Alzheimer’s disease, obesity-rela
Externí odkaz:
https://doaj.org/article/1e1ddb2b37e34fb781b350a1572be788
Autor:
Rong Chen, Shiqing Zhang, Fang Liu, Lin Xia, Chong Wang, Siamak Sandoghchian Shotorbani, Huaxi Xu, Subrata Chakrabarti, Tianqing Peng, Zhaoliang Su
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 1, Pp 128-141 (2023)
Cardiac-resident macrophages (CRMs) play important roles in homeostasis, cardiac function, and remodeling. Although CRMs play critical roles in cardiac regeneration of neonatal mice, their roles are yet to be fully elucidated. Therefore, this study a
Externí odkaz:
https://doaj.org/article/9ebb9255ea454c4788180d72b91c5159
Autor:
Yiru Jiang, Linkun Han, Jian Meng, Zijie Wang, Yunqiang Zhou, Huilong Yuan, Hui Xu, Xian Zhang, Yingjun Zhao, Jinsheng Lu, Huaxi Xu, Chen Zhang, Yun-wu Zhang
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 246-258 (2022)
Fragile X syndrome (FXS) is caused by the loss of the fragile X messenger ribonucleoprotein 1 (FMRP) encoded by the FMR1 gene. Gene therapy using adeno-associated virus (AAV) to restore FMRP expression is a promising therapeutic strategy. However, so
Externí odkaz:
https://doaj.org/article/8b48cd6e3df7428a81b80e51c2dc9255
Autor:
Fa-rong Liu, Yunqiang Zhou, Yong Wang, Ling-ling Huang, Xian Zhang, Hong Luo, Su-ying Wu, Hai-yan Lyu, Li-huan Huang, Huaxi Xu, Yun-wu Zhang
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Bipolar disorder (BD) is a complex psychiatric disorder with strong heritability. Identification of new BD risk genes will help determine the mechanism underlying disease pathogenesis. In the present study, we carried out whole genome sequen
Externí odkaz:
https://doaj.org/article/f35078d8962041e981f470b8a9b024e4
Autor:
Bing Zhu, Yan Liu, Spring Hwang, Kailey Archuleta, Huijie Huang, Alex Campos, Rabi Murad, Juan Piña-Crespo, Huaxi Xu, Timothy Y. Huang
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-24 (2022)
Abstract Background Alzheimer’s disease (AD) is a neurodegenerative disorder that manifests sequential Aβ and tau brain pathology with age-dependent onset. Variants in the microglial immune receptor TREM2 are associated with enhanced risk of onset
Externí odkaz:
https://doaj.org/article/0541d50ee2fb468380405e80ced1fc80
Autor:
Hongsheng Zhang, Lin Shao, Zhihao Lin, Quan-Xin Long, Huilong Yuan, Lujian Cai, Guangtong Jiang, Xiaoyi Guo, Renzhi Yang, Zepeng Zhang, Bingchang Zhang, Fan Liu, Zhiyong Li, Qilin Ma, Yun-Wu Zhang, Ai-Long Huang, Zhanxiang Wang, Yingjun Zhao, Huaxi Xu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-9 (2022)
Abstract Apolipoprotein E (APOE) plays a pivotal role in lipid including cholesterol metabolism. The APOE ε4 (APOE4) allele is a major genetic risk factor for Alzheimer’s and cardiovascular diseases. Although APOE has recently been associated with
Externí odkaz:
https://doaj.org/article/f2f83936ed45403fbfc3751497f0914e