Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Huawen Lin"'
Publikováno v:
Open Biology, Vol 8, Iss 3 (2018)
Intraflagellar transport moves proteins in and out of flagella/cilia and it is essential for the assembly of these organelles. Using whole-genome sequencing, we identified splice site mutations in two IFT genes, IFT81 (fla9) and IFT121 (ift121-2), wh
Externí odkaz:
https://doaj.org/article/68abaed6eb1f4970b6006613e1425ba4
Autor:
Huawen Lin, Zhengyan Zhang, Suyang Guo, Fan Chen, Jonathan M Kessler, Yan Mei Wang, Susan K Dutcher
Publikováno v:
PLoS Genetics, Vol 11, Iss 9, p e1005508 (2015)
CCDC39 and CCDC40 were first identified as causative mutations in primary ciliary dyskinesia patients; cilia from patients show disorganized microtubules, and they are missing both N-DRC and inner dynein arms proteins. In Chlamydomonas, we used immun
Externí odkaz:
https://doaj.org/article/d86d8804494d46ab8814725baba3dad0
Publikováno v:
PLoS Genetics, Vol 9, Iss 9, p e1003841 (2013)
Whole genome sequencing is a powerful tool in the discovery of single nucleotide polymorphisms (SNPs) and small insertions/deletions (indels) among mutant strains, which simplifies forward genetics approaches. However, identification of the causative
Externí odkaz:
https://doaj.org/article/582ac97f7a994da485fefd4ceb47b88e
Publikováno v:
PLoS Genetics, Vol 6, Iss 9, p e1001105 (2010)
The essential coenzyme nicotinamide adenine dinucleotide (NAD+) plays important roles in metabolic reactions and cell regulation in all organisms. Bacteria, fungi, plants, and animals use different pathways to synthesize NAD+. Our molecular and genet
Externí odkaz:
https://doaj.org/article/53c82afa1452483aa668d73d698439a8
Autor:
Takashi Ochi, Francesco Boselli, Christopher M. Johnson, Jerome Jullien, Huawen Lin, Raymond E. Goldstein, Fanni Gergely, Tom L. Blundell, Valentina Quarantotti, Stephen H. McLaughlin, Stefan M.V. Freund, Susan K. Dutcher, I.R. e Silva, Mark van Breugel, Yuu Kimata, Andrew N. Blackford, Deepak D. Barnabas, Stephen P. Jackson
Publikováno v:
Structure(London, England:1993)
Summary Centrioles are cylindrical assemblies whose peripheral microtubule array displays a 9-fold rotational symmetry that is established by the scaffolding protein SAS6. Centriole symmetry can be broken by centriole-associated structures, such as t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc30afd2a17d8e6e65ea5bc5714918b6
https://eprints.whiterose.ac.uk/159470/8/1-s2.0-S0969212620301313-main.pdf
https://eprints.whiterose.ac.uk/159470/8/1-s2.0-S0969212620301313-main.pdf
Publikováno v:
Plant Physiology. 178:1436-1447
Insertional mutagenesis, in which a piece of exogenous DNA is integrated randomly into the genomic DNA of the recipient cell, is a useful method to generate new mutants with phenotypes of interest. The unicellular green alga Chlamydomonas reinhardtii
The IDA3 adapter, required for intraflagellar transport of I1 dynein, is regulated by ciliary length
Autor:
Ryosuke Yamamoto, Winfield S. Sale, Huawen Lin, Gang Fu, Daniela Nicastro, Brian A. Lewis, Avanti Gokhale, Juyeon Hwang, Fan Yang, Lea M. Alford, Ritsu Kamiya, Susan K. Dutcher, Karl F. Lechtreck, Emily L. Hunter, Maureen Wirschell
Publikováno v:
Molecular Biology of the Cell
We determined how the ciliary motor I1 dynein is transported. A specialized adapter, IDA3, facilitates I1 dynein attachment to the ciliary transporter called intraflagellar transport (IFT). Loading of IDA3 and I1 dynein on IFT is regulated by ciliary
Publikováno v:
2019 IEEE 8th International Conference on Fluid Power and Mechatronics (FPM).
In some special hydraulic position control systems, the actuator is required to operate at a high speed in a short time. In order to reduce the installed power of the hydraulic pump station, the accumulator can be used as the auxiliary power source t
Publikováno v:
Journal of Cell Science
Mutations in transition zone genes change the composition of the ciliary proteome. We isolated new mutations in RPGRIP1L (denotated as RPG1 in algae) that affect the localization of the transition zone protein NPHP4 in the model organism Chlamydomona
Figure 1: Protein sequence alignment of IFT81; Figure 2: The IFT81 transcripts and the IFT81 protein at 32˚C are similar to those at 21˚C; Figure 3: Protein sequence alignment of DGR14.; Figure4: Nucleotide sequences and splicing details of IFT121
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0422f9a4098874e41a204d1e1aae7cda