Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Huawei Qiu"'
Autor:
Zhen Liu, Wilson Guzman, Parker Johnson, Megan McLaughlin, Caitlin O’Toole, Magali Pederzoli-Ribeil, Huawei Qiu, Margaret Karow, Tim Clackson, Jennifer O’Neil, Ugur Eskiocak, Miso Park, Benjamin Nicholson, John C Williams, Kurt A Jenkins, Deborah Moore-Lai, Veronica Flesch, Ronan C O’Hagan, Ulrich Rodeck
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 12 (2023)
Introduction The clinical benefit of the anti-CTLA-4 monoclonal antibody (mAb) ipilimumab has been well established but limited by immune-related adverse events, especially when ipilimumab is used in combination with anti-PD-(L)1 mAb therapy. To over
Externí odkaz:
https://doaj.org/article/d160ab0121654c39a0d99d2106b97ef4
Autor:
Jia Chen, Wilson Guzman, Parker Johnson, Megan McLaughlin, Kurt Jenkins, Hanumantha Rao Madala, Magali Pederzoli-Ribeil, Huawei Qiu, Ekta Patel, Natalia Malkova, Sallyann Vu, Rebekah O'Donnell, Manoussa Fanny, Oleg Yerov, Caitlin O'Toole, Benjamin Nicholson, Bill Avery, Ronan O'Hagan, Jennifer O'Neil
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/736e0ac102364c88b70229d6db94785b
Autor:
Brian C. Mackness, Julie A. Jaworski, Ekaterina Boudanova, Anna Park, Delphine Valente, Christine Mauriac, Olivier Pasquier, Thorsten Schmidt, Mostafa Kabiri, Abdullah Kandira, Katarina Radošević, Huawei Qiu
Publikováno v:
mAbs, Vol 11, Iss 7, Pp 1276-1288 (2019)
The neonatal Fc receptor (FcRn) promotes antibody recycling through rescue from normal lysosomal degradation. The binding interaction is pH-dependent with high affinity at low pH, but not under physiological pH conditions. Here, we combined rational
Externí odkaz:
https://doaj.org/article/33ccb6b5fc1f42d784a69baa02b5d1f8
Autor:
Huawei Qiu, Ronnie Wei, Julie Jaworski, Ekaterina Boudanova, Heather Hughes, Scott VanPatten, Anders Lund, Jaime Day, Yanfeng Zhou, Tracey McSherry, Clark Q. Pan, Rebecca Sendak
Publikováno v:
mAbs, Vol 11, Iss 7, Pp 1266-1275 (2019)
Deamidation evaluation and mitigation is an important aspect of therapeutic antibody developability assessment. We investigated the structure and function of the Asn-Gly deamidation in a human anti-CD52 IgG1 antibody light chain complementarity-deter
Externí odkaz:
https://doaj.org/article/930e74582c1343a88440d28599c59bdc
Autor:
Wilson Guzman, Minjie Zhang, Parker Johnson, Megan McLaughlin, Kurt Jenkins, Hsin-Jung Wu, Hanumantha Rao Madala, Caitlin O’Toole, Magali Pederzoli-Ribeil, Raphael Rozenfeld, Huawei Qiu, Margaret Karow, Tim Clackson, Ronan O’Hagan, Jennifer O’Neil, Ugur Eskiocak
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/3724762c0d9f4cefad90ea99d2af8b60
Autor:
Delphine Valente, Christine Mauriac, Thorsten Schmidt, Ingo Focken, Jochen Beninga, Brian Mackness, Huawei Qiu, Pascale Vicat, Abdullah Kandira, Katarina Radošević, Srini Rao, John Darbyshire, Mostafa Kabiri
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Monoclonal antibodies (mAbs) are among the fastest growing and most effective therapies for myriad diseases. Multispecific antibodies are an emerging class of novel therapeutics that can target more than one tumor- or immune-associated modulators per
Externí odkaz:
https://doaj.org/article/131fb11c1c2b4c5080fd734830439d0d
Autor:
Qun Zhou, Julie Jaworski, Yanfeng Zhou, Delphine Valente, Joanne Cotton, Denise Honey, Ekaterina Boudanova, Jochen Beninga, Ercole Rao, Ronnie Wei, Christine Mauriac, Clark Pan, Anna Park, Huawei Qiu
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Antibodies mediate effector functions through Fcγ receptor (FcγR) interactions and complement activation, causing cytokine release, degranulation, phagocytosis, and cell death. They are often undesired for development of therapeutic antibodies wher
Externí odkaz:
https://doaj.org/article/52f85e2c458f442a984fd835414cf406
Autor:
Qun Zhou, Josephine Kyazike, Ekaterina Boudanova, Michael Drzyzga, Denise Honey, Robert Cost, Lihui Hou, Francis Duffieux, Marie-Priscille Brun, Anna Park, Huawei Qiu
Publikováno v:
Pharmaceuticals, Vol 14, Iss 7, p 672 (2021)
Site-specific antibody conjugations generate homogeneous antibody-drug conjugates with high therapeutic index. However, there are limited examples for producing the site-specific conjugates with a drug-to-antibody ratio (DAR) greater than two, especi
Externí odkaz:
https://doaj.org/article/1d1d4e9bcd2c468c9df96f3a0a831d57
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Genetic alterations in the protein acid sphingomyelinase (ASM) lead to ASM deficiency and have been associated with Niemann–Pick disease. Here, the authors report the crystal structures of ASM alone and bound to its product, and discuss the catalyt
Externí odkaz:
https://doaj.org/article/eda182e9ef134dd2b69154514ce76ea7
Autor:
Hongmei Zhao, Jozsef Karman, Ji-Lei Jiang, Jinhua Zhang, Nathan Gumlaw, John Lydon, Qun Zhou, Huawei Qiu, Canwen Jiang, Seng H Cheng, Yunxiang Zhu
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63530 (2013)
Crosslinking ligand-engaged cytotoxic T lymphocyte antigen-4 (CTLA-4) to the T cell receptor (TCR) with a bispecific fusion protein (BsB) comprised of a mutant mouse CD80 and lymphocyte activation antigen-3 (LAG-3) has been shown to attenuate TCR sig
Externí odkaz:
https://doaj.org/article/4bc2461a64c84f2eb8cb8f2124dc291e