Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Huasong Tian"'
Autor:
Sally M. Dewhurst, Xiaotong Yao, Joel Rosiene, Huasong Tian, Julie Behr, Nazario Bosco, Kaori K. Takai, Titia de Lange, Marcin Imieliński
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Telomere crisis has been shown to induce chromothripsis and breakage fusion bridge (BFB) cycles in vitro. Here, the authors show that telomere crisis generates a much broader spectrum of structural variations, implying that cancers without chromothri
Externí odkaz:
https://doaj.org/article/df07fee0b7114bef9405a63b5e335004
Autor:
Catherine Marquer, Huasong Tian, Julie Yi, Jayson Bastien, Claudia Dall'Armi, YoungJoo Yang-Klingler, Bowen Zhou, Robin Barry Chan, Gilbert Di Paolo
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
The small GTPase Arf6 regulates intracellular transport, phosphoinositide signalling and cholesterol homeostasis. Here, Marquer et al. show that loss of Arf6 causes cholesterol accumulation in endosomes due to defects in phosphoinositide-dependent re
Externí odkaz:
https://doaj.org/article/2c2430c3a2ba4bf78869ca4b08f032c7
Expression of the Carboxy-Terminal Portion of MUC16/CA125 Induces Transformation and Tumor Invasion.
Autor:
Thapi D Rao, Huasong Tian, Xun Ma, Xiujun Yan, Sahityasri Thapi, Nikolaus Schultz, Nestor Rosales, Sebastien Monette, Amy Wang, David M Hyman, Douglas A Levine, David Solit, David R Spriggs
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126633 (2015)
The CA125 antigen is found in the serum of many patients with serous ovarian cancer and has been widely used as a disease marker. CA125 has been shown to be an independent factor for clinical outcome in this disease. In The Cancer Genome Atlas ovaria
Externí odkaz:
https://doaj.org/article/6627675a7f23444b9ca77c59e7a3631d
Autor:
Wahida H Ali, Qin Chen, Kathleen E Delgiorno, Wenjuan Su, Jason C Hall, Tsunaki Hongu, Huasong Tian, Yasunori Kanaho, Gilbert Di Paolo, Howard C Crawford, Michael A Frohman
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55325 (2013)
Cell migration and phagocytosis ensue from extracellular-initiated signaling cascades that orchestrate dynamic reorganization of the actin cytoskeleton. The reorganization is mediated by effector proteins recruited to the site of activity by locally-
Externí odkaz:
https://doaj.org/article/4ccb4dc8e5cf4eb0ac4dc64d3575e3de
Autor:
Andrew L. H. Webster, Mathijs A. Sanders, Krupa Patel, Ralf Dietrich, Raymond J. Noonan, Francis P. Lach, Ryan R. White, Audrey Goldfarb, Kevin Hadi, Matthew M. Edwards, Frank X. Donovan, Remco M. Hoogenboezem, Moonjung Jung, Sunandini Sridhar, Tom F. Wiley, Olivier Fedrigo, Huasong Tian, Joel Rosiene, Thomas Heineman, Jennifer A. Kennedy, Lorenzo Bean, Rasim O. Rosti, Rebecca Tryon, Ashlyn-Maree Gonzalez, Allana Rosenberg, Ji-Dung Luo, Thomas S. Carroll, Sanjana Shroff, Michael Beaumont, Eunike Velleuer, Jeff C. Rastatter, Susanne I. Wells, Jordi Surrallés, Grover Bagby, Margaret L. MacMillan, John E. Wagner, Maria Cancio, Farid Boulad, Theresa Scognamiglio, Roger Vaughan, Kristin G. Beaumont, Amnon Koren, Marcin Imielinski, Settara C. Chandrasekharappa, Arleen D. Auerbach, Bhuvanesh Singh, David I. Kutler, Peter J. Campbell, Agata Smogorzewska
Publikováno v:
Nature, 612(7940), 495-502. Nature Publishing Group
Nature
Nature
Fanconi anaemia (FA), a model syndrome of genome instability, is caused by a deficiency in DNA interstrand crosslink repair resulting in chromosome breakage1–3. The FA repair pathway protects against endogenous and exogenous carcinogenic aldehydes4
Autor:
Aditya S. Deshpande, Netha Ulahannan, Matthew Pendleton, Xiaoguang Dai, Lynn Ly, Julie M. Behr, Stefan Schwenk, Will Liao, Michael A. Augello, Carly Tyer, Priyesh Rughani, Sarah Kudman, Huasong Tian, Hannah G. Otis, Emily Adney, David Wilkes, Juan Miguel Mosquera, Christopher E. Barbieri, Ari Melnick, David Stoddart, Daniel J. Turner, Sissel Juul, Eoghan Harrington, Marcin Imieliński
Publikováno v:
Nature Biotechnology. 40:1488-1499
High-order three-dimensional (3D) interactions between more than two genomic loci are common in human chromatin, but their role in gene regulation is unclear. Previous high-order 3D chromatin assays either measure distant interactions across the geno
Autor:
Jeremy Setton, Kevin Hadi, Huasong Tian, Arnaud Da Cruz Paula, Joel Rosiene, Zi-Ning Choo, Julie Behr, Xiaotong Yao, Olivier Elemento, Britta Weigelt, Nadeem Riaz, Jorge S Reis-Filho, Marcin Imielinski, Simon N Powell
Publikováno v:
Cancer Research. 82:P2-06
Background: Cancer genomes provide a durable record of the genetic alterations that are acquired during normal cell development and carcinogenesis from DNA damage and DNA repair defects. As DNA repair-deficient tumors often become dependent on backup
Autor:
Sunandini Sridhar, David I. Kutler, Bhuvanesh Singh, Susanne I. Wells, Ji-Dung Luo, Mathijs A. Sanders, Margaret L. MacMillan, Ashlyn-Maree Gonzalez, Lorenzo Bean, Rebecca Tryon, Huasong Tian, Jordi Surrallés, Arleen D. Auerbach, Kevin Hadi, Moonjung Jung, Ralf Dietrich, Matthew M. Edwards, Eunike Velleuer, Krupa R. Patel, Frank X. Donovan, Amnon Koren, Marcin Imielinski, Audrey Goldfarb, Ozgur Rosti, Jeffrey C. Rastatter, Theresa Scognamiglio, John E. Wagner, Andrew L.H. Webster, Maria Cancio, Olivier Fedrigo, Agata Smogorzewska, Jennifer A. Kennedy, Thomas Carrol, Grover C. Bagby, Joel Rosiene, Allana Rosenberg, Thomas Heineman, Ryan R. White, Raymond J. Noonan, Farid Boulad, Francis P. Lach, Settara C. Chandrasekharappa, Peter J. Campbell, Roger D. Vaughan
Fanconi anemia (FA), a model syndrome of genome instability, is caused by a deficiency in DNA interstrand crosslink (ICL) repair resulting in chromosome breakage1–3. The FA repair pathway comprises at least 22 FANC proteins including BRCA1 and BRCA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9afd781051fca6c3cb7bdbe0af4e0c0
https://doi.org/10.1101/2021.08.14.456365
https://doi.org/10.1101/2021.08.14.456365
Autor:
Marcin Imielinski, Aditya Deshpande, Xiaotong Yao, Joel Rosiene, Julie M. Behr, Lange Td, Huasong Tian, Kevin Hadi
SummaryRecent pan-cancer studies have delineated patterns of structural genomic variation across thousands of tumor whole genome sequences. It is not known to what extent the shortcomings of short read (≤ 150 bp) whole genome sequencing (WGS) used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba1a9778aa8aeefd6eaf2df3412ef816
https://doi.org/10.1101/2021.05.26.445837
https://doi.org/10.1101/2021.05.26.445837
Autor:
Joel Rosiene, Kaori K. Takai, Sally M. Dewhurst, Huasong Tian, Julie M. Behr, Xiaotong M Yao, Nazario Bosco, Titia de Lange, Marcin Imielinski
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Telomere crisis contributes to cancer genome evolution, yet only a subset of cancers display breakage-fusion-bridge (BFB) cycles and chromothripsis, hallmarks of experimental telomere crisis identified in previous studies. We examine the spectrum of