Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Huanzhu Jiang"'
Autor:
Jingxuan Guo, Huanzhu Jiang, David Schuftan, Jonathan D. Moreno, Ghiska Ramahdita, Lavanya Aryan, Druv Bhagavan, Jonathan Silva, Nathaniel Huebsch
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109954- (2024)
Summary: Hypertension is a major cause of morbidity and mortality in patients with hypertrophic cardiomyopathy (HCM), suggesting a potential role for mechanics in HCM pathogenesis. Here, we developed an in vitro physiological model to investigate how
Externí odkaz:
https://doaj.org/article/35f0bd6352214576a41ec5a3d3f50080
Autor:
Zain Clapacs, Sydney Neal, David Schuftan, Xiaohong Tan, Huanzhu Jiang, Jingxuan Guo, Jai Rudra, Nathaniel Huebsch
Publikováno v:
Gels, Vol 7, Iss 3, p 101 (2021)
Cell encapsulating scaffolds are necessary for the study of cellular mechanosensing of cultured cells. However, conventional scaffolds used for loading cells in bulk generally fail at low compressive strain, while hydrogels designed for high toughnes
Externí odkaz:
https://doaj.org/article/9aad246b5bba4ee5bbef54e5de20973d
Autor:
Nathaniel Huebsch, Kasoorelope Oguntuyo, Huanzhu Jiang, Zoë Boodram, Brandon Rios, Jingxuan Guo
Publikováno v:
Cell Mol Bioeng
INTRODUCTION: In clinical and animal studies, Hypertrophic Cardiomyopathy (HCM) shares many similarities with non-inherited cardiac hypertrophy induced by pressure overload (hypertension). This suggests a potential role for mechanical stress in primi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb37c73e60084c7f7155fcef7234f7e0
https://doi.org/10.1007/s12195-021-00684-x
https://doi.org/10.1007/s12195-021-00684-x
Autor:
Jingxuan Guo, Huanzhu Jiang, Jonathan Moreno, Druv Bhagavan, Allie Li, Ralph Damiano, Jonathan R Silva, Sharon Cresci, Nathaniel Huebsch
Publikováno v:
Circulation. 144
Introduction: Modeling hypertrophic cardiomyopathy (HCM) with human induced pluripotent stem cell (hiPSC) derived cardiomyocytes is challenging because of the immaturity of hiPSC-derived cardiomyocytes along with the need to recapitulate non-genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9be743bddc1805102bb9c6390a868c4c
https://doi.org/10.1161/circ.144.suppl_1.11290
https://doi.org/10.1161/circ.144.suppl_1.11290
Autor:
Brennan Kandalaft, Ghiska Ramahdita, Daniel W. Simmons, Guy M. Genin, Brandon Rios, Kasoorelope Oguntuyo, Missy Pear, David Schuftan, Spencer P. Lake, Nathaniel Huebsch, Huanzhu Jiang, Mary K. Munsell, Jingxuan Guo
Publikováno v:
ACS biomaterials scienceengineering. 7(7)
Mechanical loading plays a critical role in cardiac pathophysiology. Engineered heart tissues derived from human induced pluripotent stem cells (iPSCs) allow rigorous investigations of the molecular and pathophysiological consequences of mechanical c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb4440a85f2965ae2e661857cbf62e23
https://pubmed.ncbi.nlm.nih.gov/34275296
https://pubmed.ncbi.nlm.nih.gov/34275296