Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Huanqiu Li"'
Autor:
Chunxiao Liu, Hui Wang, Lu Han, Yifan Zhu, Shurui Ni, Jingke Zhi, Xiping Yang, Jiayi Zhi, Tian Sheng, Huanqiu Li, Qinghua Hu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Purinergic signaling plays a causal role in the pathogenesis of inflammatory bowel disease. Among purinoceptors, only P2Y14R is positively correlated with inflammatory score in mucosal biopsies of ulcerative colitis patients, nevertheless, t
Externí odkaz:
https://doaj.org/article/aff8abc0d4cf45259de5ca610d84b335
Autor:
Mengmeng Wang, Zhoudong Zhang, Mengxi Chen, Yixin Lv, Sheng Tian, Fanyi Meng, Yawen Zhang, Xuqin Guo, Yinshuang Chen, Man Yang, Jiawei Li, Tian Qiu, Fang Xu, Zhi Li, Qi Zhang, Jie Yang, Jing Sun, Hongjian Zhang, Haiyang Zhang, Huanqiu Li, Weipeng Wang
Publikováno v:
Cell Death and Disease, Vol 14, Iss 8, Pp 1-13 (2023)
Abstract Metastatic colorectal cancer (mCRC) is a major cause of cancer-related mortality due to the absence of effective therapeutics. Thus, it is urgent to discover new drugs for mCRC. Fucosyltransferase 8 (FUT8) is a potential therapeutic target w
Externí odkaz:
https://doaj.org/article/7a9c042799264e70a9230d15a9ae936a
Autor:
Yawen Zhang, Mengmeng Wang, Fanyi Meng, Man Yang, Yinshuang Chen, Xuqin Guo, Weiwei Wang, Yifan Zhu, Yundi Guo, Chunlai Feng, Shen Tian, Hongjian Zhang, Huanqiu Li, Jing Sun, Weipeng Wang
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract As the modulation of serine/arginine-rich splicing factor 3 (SRSF3) may be therapeutically beneficial to colorectal cancer (CRC) treatment, the identification of novel SRSF3 inhibitors is highly anticipated. However, pharmaceutical agents ta
Externí odkaz:
https://doaj.org/article/11ae711ee50748e1b4fcd20539d8e368
Autor:
Chunxiao Liu, Mengze Zhou, Wenjiao Jiang, Shumin Ye, Sheng Tian, Cheng Jiang, Kun Hao, Huanqiu Li, Qinghua Hu
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The fate of infiltrating neutrophils in inflamed joints determines the development of acute gouty arthritis (AGA). GPR105 highly expressed in human neutrophils is sensitive to monosodium urate crystals (MSU); nevertheless, the roles of GPR105 in AGA
Externí odkaz:
https://doaj.org/article/2cccb2be2ffc4f8188c27717008c4075
Autor:
Weiwei Wang, Chunxiao Liu, Hanwen Li, Sheng Tian, Yingxian Liu, Nanxi Wang, Duanyang Yan, Huanqiu Li, Qinghua Hu
Publikováno v:
Journal of Advanced Research, Vol 23, Iss , Pp 133-142 (2020)
P2Y14 nucleotide receptor is a Gi protein-coupled receptor, which is widely involved in physiological and pathologic events. Although several P2Y14R antagonists have been developed thus far, few have successfully been developed into a therapeutic dru
Externí odkaz:
https://doaj.org/article/303e103d00e441c8acf0bcfa726a6c51
Autor:
Yifan Zhu, Mengze Zhou, Xiangyu Cheng, Hui Wang, Yehong Li, Yueyue Guo, Yaxuan Wang, Sheng Tian, Tianqi Mao, Zhoudong Zhang, Duxin Li, Qinghua Hu, Huanqiu Li
Publikováno v:
Journal of Medicinal Chemistry. 66:6315-6332
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 23
Abstract: Glycogen synthase kinase-3 (GSK3) is one of the important serine/threonine protein kinases and has two isoforms, namely, GSK3α and GSK3β. GSK3 inhibits glycogen synthase activity through phosphorylation. It plays a key role in various pat
Autor:
Yuxin Li, Yehong Li, Yifan Zhu, Wen Ji, Yaxuan Wang, Xinli Dong, Xin Zhao, Ting Wang, Sheng Tian, Qinghua Hu, Huanqiu Li, Mengze Zhou
Publikováno v:
Phytomedicine. 115:154851
Publikováno v:
Current medicinal chemistry.
Background: STAT3 (signal transducer and activator of transcription 3) is a member of the STAT family of proteins that function as signal transducers and transcription factors. Previous research has demonstrated its importance in cell proliferation,
Publikováno v:
Current Medicinal Chemistry. 28:569-582
Background: Inflammation is the body’s immune system’s fast coordinating response to irritants caused by pathogens, external injuries, and chemical or radiation effects. The nucleotidebinding oligomerization domain-like receptor family pyrin doma