Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Huanji Xu"'
Publikováno v:
npj Biofilms and Microbiomes, Vol 10, Iss 1, Pp 1-15 (2024)
Abstract A high-fat diet (HFD) may be linked to an increased colorectal cancer (CRC) risk. Stem cell proliferation and adipokine release under inflammatory and obese conditions are the main factors regulating CRC progression. Furthermore, alterations
Externí odkaz:
https://doaj.org/article/46528a726044410baa6eb3420e2f109f
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Cholesterol esterification is often dysregulated in cancer. Sterol O-acyl-transferase 1 (SOAT1) plays an important role in maintaining cellular cholesterol homeostasis by catalyzing the formation of cholesterol esters from cholesterol and long-chain
Externí odkaz:
https://doaj.org/article/016c94d625a1460b975c94ee863eebf0
Publikováno v:
Heliyon, Vol 9, Iss 6, Pp e17295- (2023)
Sorafenib resistance is one of the main obstacles to the treatment of advanced hepatocellular carcinoma (HCC). Stress proteins TRIB3 and STC2 confer cell resistance to a variety of stresses, including hypoxia, nutritional deprivation, and other pertu
Externí odkaz:
https://doaj.org/article/6661ffb52f764029842726794e68f124
Publikováno v:
Cell Death and Disease, Vol 13, Iss 7, Pp 1-15 (2022)
Abstract Aggresome formation is a protective cellular response to counteract proteasome dysfunction by sequestering misfolded proteins and reducing proteotoxic stress. Autophagic degradation of the protein aggregates is considered to be a key compens
Externí odkaz:
https://doaj.org/article/8279cea700cb4df680e9e8d4c40c5b7f
Ursodeoxycholic acid suppresses the malignant progression of colorectal cancer through TGR5-YAP axis
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-12 (2021)
Abstract The Hippo/YAP pathway plays an important role in the development of cancers. Previous studies have reported that bile acids can activate YAP (Yes Associated Protein) to promote tumorigenesis and tumor progression. Ursodeoxycholic acid (UDCA)
Externí odkaz:
https://doaj.org/article/03062a90a39e4302aa578664194787c3
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Cholesterol metabolism is often dysregulated in cancer. Squalene monooxygenase (SQLE) is the second rate-limiting enzyme involved in cholesterol synthesis. Since the discovery of SQLE dysregulation in cancer, compelling evidence has indicated that SQ
Externí odkaz:
https://doaj.org/article/ffa439d81ff74d9cbe78eeeba07a7fd2
Targeting SERT promotes tryptophan metabolism: mechanisms and implications in colon cancer treatment
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-17 (2021)
Abstract Background Serotonin signaling has been associated with tumorigenesis and tumor progression. Targeting the serotonin transporter to block serotonin cellular uptake confers antineoplastic effects in various tumors, including colon cancer. How
Externí odkaz:
https://doaj.org/article/023109eab6204f13ac94e68db6d7d014
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-15 (2021)
Abstract Lipid homeostasis plays a fundamental role in the development of hepatocellular carcinoma (HCC). However, the mechanisms that regulate lipid homeostasis to avoid lipotoxicity in HCC remain elusive. Here, we found high-fat diet (HFD) improved
Externí odkaz:
https://doaj.org/article/f664cff42b1f4e41b464eedbbc2f521f
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-13 (2021)
Abstract Intracellular free cholesterol can be converted to cholesteryl ester and stored as lipid droplets through SOAT1-mediated esterification. Compelling evidence implicate targeting SOAT1 as a promising therapeutic strategy for cancer management.
Externí odkaz:
https://doaj.org/article/0d35d8bdcbcd464c97f9041ac1852086
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 37, Iss 1, Pp 1-14 (2018)
Abstract Background ERRα, a constitutive transcription factor that regulates energy metabolism, plays an important role in the progression of various tumours. However, its role in cell survival and proliferation and its implication in targeted thera
Externí odkaz:
https://doaj.org/article/9fdca162d3514b45ab7b7dc4d18d496e