Impact of Human Cytomegalovirus Infection and its Immune Response on Survival of Patients with Ovarian Cancer

Autor: Angelique Flöter Rådestad, Atosa Estekizadeh, Huanhuan L Cui, Ourania N. Kostopoulou, Belghis Davoudi, Angelica Lindén Hirschberg, Joseph Carlson, Afsar Rahbar, Cecilia Söderberg-Naucler

Publikováno v: Translational Oncology, Vol 11, Iss 6, Pp 1292-1300 (2018)

Human cytomegalovirus (HCMV) has been detected in various types of tumors. We studied the prevalence of HCMV in ovarian cancer and its relation to clinical outcome. Paraffin-embedded tissues obtained prospectively from 45 patients with ovarian cancer

Externí odkaz: https://doaj.org/article/3cf15a01da464fac9a153d7dda5f954e

Human cytomegalovirus hijacks host stress response fueling replication stress and genome instability

Autor: Joanna Maria Merchut-Maya, Jiri Bartek, Jirina Bartkova, Panagiotis Galanos, Mattia Russel Pantalone, MyungHee Lee, Huanhuan L. Cui, Patrick J. Shilling, Christian Beltoft Brøchner, Helle Broholm, Apolinar Maya-Mendoza, Cecilia Söderberg-Naucler

Publikováno v: Cell Death & Differentiation. 29:1639-1653

Viral infections enhance cancer risk and threaten host genome integrity. Although human cytomegalovirus (HCMV) proteins have been detected in a wide spectrum of human malignancies and HCMV infections have been implicated in tumorigenesis, the underly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127ae27ffda1032b483b49878eef42ad
https://doi.org/10.1038/s41418-022-00953-w

HIV-1 Nef mobilizes lipid rafts in macrophages through a pathway that competes with ABCA1-dependent cholesterol efflux

Autor: Huanhuan L. Cui, Angela Grant, Nigora Mukhamedova, Tatiana Pushkarsky, Lucas Jennelle, Larisa Dubrovsky, Katharina Gaus, Michael L. Fitzgerald, Dmitri Sviridov, Michael Bukrinsky

Publikováno v: Journal of Lipid Research, Vol 53, Iss 4, Pp 696-708 (2012)

HIV infection, through the actions of viral accessory protein Nef, impairs activity of cholesterol transporter ABCA1, inhibiting cholesterol efflux from macrophages and elevating the risk of atherosclerosis. Nef also induces lipid raft formation. In

Externí odkaz: https://doaj.org/article/e59aa69992e94a1c893ec568bab6cedd

Heterogeneity of Metabolic Vulnerability in Imatinib -Resistant Gastrointestinal Stromal Tumor

Autor: Wen-Kuan, Huang, Jiwei, Gao, Ziqing, Chen, Hao, Shi, Juan, Yuan, Huanhuan L, Cui, Chun-Nan, Yeh, Robert, Bränström, Catharina, Larsson, Shuijie, Li, Weng-Onn, Lui

Publikováno v: Cells
Volume 9
Issue 6
Cells, Vol 9, Iss 1333, p 1333 (2020)

Metabolic reprogramming is a hallmark of cancer cells in response to targeted therapy. Decreased glycolytic activity with enhanced mitochondrial respiration secondary to imatinib has been shown in imatinib-sensitive gastrointestional stromal tumors (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::86b945af6ef02dec97686bf21fd55c76

Increased production of periplasmic proteins in Escherichia coli by directed evolution of the translation initiation region

Autor: Patrick J. Shilling, Kiavash Mirzadeh, Rageia Elfageih, Morten H. H. Nørholm, Alister J. Cumming, Maja Rennig, Daniel O. Daley, Huanhuan L. Cui

Publikováno v: Microbial Cell Factories
Microbial Cell Factories, Vol 19, Iss 1, Pp 1-12 (2020)
Mirzadeh, K, Shilling, P J, Elfageih, R, Cumming, A J, Cui, H L, Rennig, M, Nørholm, M H H & Daley, D O 2020, ' Increased production of periplasmic proteins in Escherichia coli by directed evolution of the translation initiation region ', Microbial Cell Factories, vol. 19, 85 . https://doi.org/10.1186/s12934-020-01339-8

Background Recombinant proteins are often engineered with an N-terminal signal peptide, which facilitates their secretion to the oxidising environment of the periplasm (gram-negative bacteria) or the culture supernatant (gram-positive bacteria). A co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc234a94ad87eea88338a8e21e192d4
https://doi.org/10.1186/s12934-020-01339-8