Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Huangyu Jiang"'
Autor:
Xuejun Zeng, Jian Shi, Min Zhao, Qingwei Chen, Liping Wang, Huangyu Jiang, Feifei Luo, Lijun Zhu, Linlin Lu, Xinchun Wang, Zhongqiu Liu
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166239 (2016)
This study aimed to determine the reaction kinetics of the regioselective glucuronidation of diosmetin and chrysoeriol, two important methylated metabolites of luteolin, by human liver microsomes (HLMs) and uridine-5'-diphosphate glucuronosyltransfer
Externí odkaz:
https://doaj.org/article/e2f5feff62244de9b22cb4172654f7bb
Autor:
KUNXIAN FENG, CHENGFANG JIAN, HAIHUA XIAO, HUANGYU JIANG, JINPING YANG, MENGLI YANG, ANDRE SUN, WENMING SONG, ALEXANDER V. CHESTKOV, NATALYA I. VASILEVICH, LICHUN SUN
Publikováno v:
Anticancer Research. 43:2609-2624
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8c47c70e3dfb16c00c50fcce69c235c
https://doi.org/10.21873/anticanres.16428
https://doi.org/10.21873/anticanres.16428
Abstract 5345: The application of CDK16 inhibitors in the treatment of triple-negative breast cancer
Autor:
Haihua Xiao, Huangyu Jiang, Kunxian Feng, Mengli Yang, Jinping Yang, Chengfang Jian, Yuan Tian, Natalya Vasilevich, Lichun Sun
Publikováno v:
Cancer Research. 83:5345-5345
Triple-negative breast cancer (TNBC) with estrogen receptor (ER), progesterone receptor (PR) and HER2 (c-erbB-2, neu) being negatively expressed in patient cancer tissues displayed its unique clinical pathological difference from other types of breas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54ac8e0a76addf9b84052e5a1909711e
https://doi.org/10.1158/1538-7445.am2023-5345
https://doi.org/10.1158/1538-7445.am2023-5345
Autor:
Yuhuan Li, Haihui Zheng, Xiaoxiao Qi, Huangyu Jiang, Xia Gong, Jia Yu, Linlin Lu, Jiamei Chen, Hongming Zheng, Ming Hu, Ying Wang, Zhongqiu Liu, Lijun Zhu
Publikováno v:
Molecular Pharmaceutics. 14:2917-2929
Sulfation is a key process of drug disposition that generally regulates drug effectiveness and toxicity. Calycosin derived from the dry root extract of Radix Astragali exhibits a variety of biological effects that easily undergo extensive phase II me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad49e5da5507826cf9123b2ad9fd42c6
https://doi.org/10.1021/acs.molpharmaceut.7b00042
https://doi.org/10.1021/acs.molpharmaceut.7b00042
Autor:
Xiaoxiao Qi, Sijing Zeng, Haojia Wang, Haihui Zheng, Linlin Lu, Xia Yang, Jia Yu, Zhongqiu Liu, Huangyu Jiang, Lijun Zhu, Xia Gong, Liping Wang, Ming Hu, Ying Wang, Jiamei Chen
Publikováno v:
Biopharmaceuticsdrug disposition. 39(7)
This study aimed to reveal age-related changes in the expression and activity of seven hepatic drug metabolizing enzymes (DMEs) in male wild-type and breast cancer resistance protein knockout (Bcrp1-/- ) FVB mice. The protein expression of four cytoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2149b2fefa5b1b2fd32681a41054cfbc
https://pubmed.ncbi.nlm.nih.gov/30016542
https://pubmed.ncbi.nlm.nih.gov/30016542
Autor:
Xinchun Wang, Zhongqiu Liu, Lijun Zhu, Huangyu Jiang, Guiyu Zhang, Peimin Dai, Feifei Luo, Ming Hu, Linlin Lu, Liping Wang, Ying Wang
Publikováno v:
Biopharmaceutics & Drug Disposition. 36:622-635
Flavonoids occur naturally as glucosides and aglycones. Their common phenolic hydroxyl groups may trigger extensive UDP-glucuronosyltransferase (UGT)- catalysed metabolism. Unlike aglycones, glucosides contain glucose moieties. However, the influence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86f7db259d0e74c7e03d5912ccb10b25
https://doi.org/10.1002/bdd.1989
https://doi.org/10.1002/bdd.1989
Autor:
Yanjiao Ruan, Lijun Zhu, Qisong Zhang, Ying Wang, Huangyu Jiang, Xiaoxiao Qi, Jia Yu, Linlin Lu, Xia Gong, Zhong Qiu Liu
Publikováno v:
Journal of agricultural and food chemistry. 65(24)
Acacetin, an important component of acacia honey, exerts extensive therapeutic effects on many cancers. However, the sulfonation disposition of acacetin has rarely been reported. Therefore, this study aimed to investigate the sulfonation disposition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43762bfd0d9e5716ee6b0a11f15285a
https://pubmed.ncbi.nlm.nih.gov/28540728
https://pubmed.ncbi.nlm.nih.gov/28540728
Autor:
Haihui Zheng, Ming Hu, Ying Wang, Xiaoxiao Qi, Jiamei Chen, Jinjun Wu, Zhongqiu Liu, Xinchun Wang, Jia Yu, Lijun Zhu, Huangyu Jiang
Publikováno v:
Pharmaceutical research. 34(7)
To determine the mechanism responsible for acacetin glucuronide transport and the bioavailability of acacetin. Area under the curve (AUC), clearance (CL), half-life (T1/2) and other pharmacokinetic parameters were determined by the pharmacokinetic mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239ed42b6793cdbd5b6ac2bccaf36044
https://pubmed.ncbi.nlm.nih.gov/28421306
https://pubmed.ncbi.nlm.nih.gov/28421306
Autor:
Ming Hu, Xiaoyan Li, Tongmeng Yan, Jia Yu, Linlin Lu, Sijing Zeng, Zhongqiu Liu, Lijun Zhu, Xiaoxiao Qi, Huangyu Jiang, Jiamei Chen, Haihui Zheng, Cong Xie, Ying Wang
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 45(6)
FVB mice are extensively used in transgenic and pharmacokinetic research. In this study, a validated isotope label-free method was constructed using ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) to quantify 24 dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec4b4cecee2c9223c57cf41a558b313
https://pubmed.ncbi.nlm.nih.gov/28356314
https://pubmed.ncbi.nlm.nih.gov/28356314
Autor:
Huangyu Jiang, Ming Hu, Jia Yu, Linlin Lu, Yuhuan Li, Yunli Tong, Zhongqiu Liu, Jinjun Wu, Lijun Zhu, Liang Zheng, Yuting Liu, Jian Shi, Min Zhao
Publikováno v:
AAPS J
Kaempferol is a well-known flavonoid; however, it lacks extensive pharmacokinetic studies. Phase II metabolic enzymes and efflux transporters play an important role in the disposition of flavonoids. This study aimed to investigate the mechanism by wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8965556c5592baf0461e8a380e003d1a
https://pubmed.ncbi.nlm.nih.gov/27393480
https://pubmed.ncbi.nlm.nih.gov/27393480