Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Huang-Chi Du"'
Autor:
Claudia A. Soto, Huang-Chi Du, Robert G. Fox, Taegyun Yang, James Hooson, Noelle C. Anastasio, Scott R. Gilbertson, Kathryn A. Cunningham
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Hypofunction of the serotonin (5-HT) 5-HT2C receptor (5-HT2CR) has been implicated in a variety of disorders including substance use disorders. As such, approaches to enhance 5-HT2CR signaling display therapeutic potential. In the present study, we s
Externí odkaz:
https://doaj.org/article/8c3c161a6ab2410781b8ed5bd4c5a571
Autor:
Huang-Chi Du, 杜凰祺
95
We choose the substrate, glutathione (γ-Glu-Cys-Gly, GSH), of human glutathione S-transferase (GST) as a building block to synthesize a series of GST substrate-based analogs where the Cys residue is substituted by serine. The overall synthes
We choose the substrate, glutathione (γ-Glu-Cys-Gly, GSH), of human glutathione S-transferase (GST) as a building block to synthesize a series of GST substrate-based analogs where the Cys residue is substituted by serine. The overall synthes
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/61752864300341826281
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2541
A key factor for productive DNA-encoded libraries is the chemical diversity of the small molecule moiety attached to an encoding DNA oligomer. The library structure diversity is often limited to DNA-compatible chemical reactions in aqueous media. Her
Publikováno v:
Methods in Molecular Biology ISBN: 9781071625446
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::556da71e70ad339843578486388cc973
https://doi.org/10.1007/978-1-0716-2545-3_11
https://doi.org/10.1007/978-1-0716-2545-3_11
Publikováno v:
Organic & Biomolecular Chemistry. 18:9221-9226
A zinc bromide-catalyzed synthesis of 5-substituted tetrazoles via DNA-conjugated nitriles using sodium azide has been developed. The protocol offered moderate to excellent yields of tetrazoles with a broad range of substrates, including a variety of
Autor:
Srinivas, Chamakuri, Shuo, Lu, Melek Nihan, Ucisik, Kurt M, Bohren, Ying-Chu, Chen, Huang-Chi, Du, John C, Faver, Ravikumar, Jimmidi, Feng, Li, Jian-Yuan, Li, Pranavanand, Nyshadham, Stephen S, Palmer, Jeroen, Pollet, Xuan, Qin, Shannon E, Ronca, Banumathi, Sankaran, Kiran L, Sharma, Zhi, Tan, Leroy, Versteeg, Zhifeng, Yu, Martin M, Matzuk, Timothy, Palzkill, Damian W, Young
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance SARS-CoV-2 has had a crippling impact on human life globally. Vaccine development has been used as a first-line strategy for COVID-19 prevention and mitigation; however, small-molecule drugs are still vitally needed to extend treatment o
Autor:
Ravikumar Jimmidi, Kurt M. Bohren, Jeroen Pollet, Xuan Qin, Shannon E. Ronca, Timothy Palzkill, Shuo Lu, Zhifeng Yu, Damian W. Young, Srinivas Chamakuri, Zhi Tan, Ying-Chu Chen, Melek N. Ucisik, Feng Li, John C. Faver, J. Li, Stephen Palmer, Kiran L. Sharma, Martin M. Matzuk, Banumathi Sankaran, Huang-Chi Du, Leroy Versteeg, Pranavanand Nyshadham
Publikováno v:
Proceedings of the National Academy of Sciences. 118
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has killed more than 4 million humans globally, but there is no bona fide Food and Drug Administration-approved drug-like molecule to impede the COVID-19 pandemic. The sluggish pace of trad
Publikováno v:
Bioconjug Chem
A multistep protocol for the synthesis of 3,5-disubstituted 1,2,4-oxadiazoles on DNA-chemical conjugates has been developed. A set of six DNA-connected aryl nitriles were converted to corresponding amidoximes with hydroxylamine followed by the O-acyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090a184372e2e173019cba2c60d439fc
https://europepmc.org/articles/PMC6786255/
https://europepmc.org/articles/PMC6786255/
Autor:
Huang-Chi, Du, Nicholas, Simmons, John C, Faver, Zhifeng, Yu, Murugesan, Palaniappan, Kevin, Riehle, Martin M, Matzuk
Publikováno v:
Organic Letters
A hypodiboric acid system for the reduction of nitro groups on DNA–chemical conjugates has been developed. This transformation provided good to excellent yields of the reduced amine product for a variety of functionalized aromatic, heterocyclic, an
Autor:
Chamakuri, Srinivas, Shuo Lu, Ucisik, Melek Nihan, Bohren, Kurt M., Ying-Chu Chen, Huang-Chi Du, Faver, John C., Jimmidi, Ravikumar, Feng Li, Jian-Yuan Li, Nyshadham, Pranavanand, Palmer, Stephen S., Pollet, Jeroen, Xuan Qin, Ronca, Shannon E., Sankaran, Banumathi, Sharma, Kiran L., Zhi Tan, Versteeg, Leroy, Zhifeng Yu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 9/7/2021, Vol. 118 Issue 36, p1-8, 8p