Zobrazeno 1 - 10
of 950
pro vyhledávání: '"Huang Tim"'
Publikováno v:
Biomolecular Concepts, Vol 6, Iss 1, Pp 59-66 (2015)
Alternative splicing is widely recognized for its roles in regulating genes and creating gene diversity. Consequently the identification and quantification of differentially spliced transcripts is pivotal for transcriptome analysis. Here, we review t
Externí odkaz:
https://doaj.org/article/c663335d56264034a2021b744e8402f8
Publikováno v:
BMC Genomics, Vol 13, Iss Suppl 6, p S3 (2012)
Abstract Regulation of gene expression has been shown to involve not only the binding of transcription factor at target gene promoters but also the characterization of histone around which DNA is wrapped around. Some histone modification, for example
Externí odkaz:
https://doaj.org/article/be43ef57423d46e7ac460273d57d2072
Autor:
Lin, Li-Ling, Nayak, Bijaya, Osmulski, Pawel A., Wang, Exing, Wang, Chen-Pin, Valente, Philip T., Wang, Chiou-Miin, Tan, Xi, Santanam, Nalini, Wang, Tian-Li, Gaczynska, Maria E., Kost, Edward R., Huang, Tim H.-M., Kirma, Nameer B.
Publikováno v:
In Cell Reports 27 August 2024 43(8)
Publikováno v:
BMC Genomics, Vol 9, Iss Suppl 2, p S23 (2008)
Abstract We present a mixture model-based analysis for identifying differences in the distribution of RNA polymerase II (Pol II) in transcribed regions, measured using ChIP-seq (chromatin immunoprecipitation following massively parallel sequencing te
Externí odkaz:
https://doaj.org/article/cd102b2567b24f09802e27b6db6e97e9
Publikováno v:
BioData Mining, Vol 4, Iss 1, p 13 (2011)
Abstract Background DNA methylation plays a very important role in the silencing of tumor suppressor genes in various tumor types. In order to gain a genome-wide understanding of how changes in methylation affect tumor growth, the differential methyl
Externí odkaz:
https://doaj.org/article/70c8d91cd7214e73bb521dada2509008
Autor:
Yan Pearlly S, Chu Pei-Yi, Yeh Kun-Tu, Chen Chien-Min, Sun Wei-Sheng, Hung Yi-Chen, Lai Yen-Ling, Yen Jia-Yi, Kuo Tzen-Yu, Lee Kuan-Der, Tseng Min-Jen, Leu Yu-Wei, Hsu Chia-Chen, Chang Yu-Sun, Huang Tim H-M, Hsiao Shu-Huei
Publikováno v:
Journal of Biomedical Science, Vol 18, Iss 1, p 12 (2011)
Abstract Background The Cdc42-interacting protein-4, Trip10 (also known as CIP4), is a multi-domain adaptor protein involved in diverse cellular processes, which functions in a tissue-specific and cell lineage-specific manner. We previously found tha
Externí odkaz:
https://doaj.org/article/9be26350577b446aba2f099478e9ab76
Publikováno v:
BMC Bioinformatics, Vol 12, Iss 1, p 54 (2011)
Abstract Background DNA methylation has been shown to play an important role in the silencing of tumor suppressor genes in various tumor types. In order to have a system-wide understanding of the methylation changes that occur in tumors, we have deve
Externí odkaz:
https://doaj.org/article/86497dac658d46519716a9a4d4fe70ce
Autor:
Chen Ching-Shih, Huang Tim HM, Tseng Min-Jen, Teng I-Wen, Hsu Chia-Chen, Wang Shi-Gang, Shaw Arthur Y, Lin Yi-Shiuan, Leu Yu-Wei, Hsiao Shu-Huei
Publikováno v:
Journal of Biomedical Science, Vol 18, Iss 1, p 3 (2011)
Abstract Background Targeting abnormal DNA methylation represents a therapeutically relevant strategy for cancer treatment as demonstrated by the US Food and Drug Administration approval of the DNA methyltransferase inhibitors azacytidine and 5-aza-2
Externí odkaz:
https://doaj.org/article/55d5369117f748da8a2ce37bf2d5ffc9
Publikováno v:
BMC Medical Genomics, Vol 3, Iss 1, p 55 (2010)
Abstract Background The nuclear transcription factor estrogen receptor alpha (ER-alpha) is the target of several antiestrogen therapeutic agents for breast cancer. However, many ER-alpha positive patients do not respond to these treatments from the b
Externí odkaz:
https://doaj.org/article/1ae4d55973d24f5aa375d138f4db1607
Publikováno v:
BMC Bioinformatics, Vol 10, Iss 1, p 404 (2009)
Abstract Background DNA methylation plays an important role in the process of tumorigenesis. Identifying differentially methylated genes or CpG islands (CGIs) associated with genes between two tumor subtypes is thus an important biological question.
Externí odkaz:
https://doaj.org/article/260b1c0a96b74e6a8d1c9390995951c8