Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Huan-qiu Li"'
Publikováno v:
Acta Crystallographica Section E, Vol 65, Iss 12, Pp o3080-o3080 (2009)
In the title compound, C15H13N3O2S2, the dihedral angle between the aromatic rings is 87.8 (2)°. In the crystal, inversion dimers occur linked by pairs of N—H...S hydrogen bonds.
Externí odkaz:
https://doaj.org/article/3b9bce6d00654820a25ad8972d695e87
Publikováno v:
Acta Crystallographica Section E, Vol 65, Iss 12, Pp o3101-o3101 (2009)
In the title compound, C15H12ClN3O2S2, the dihedral angle between the aromatic rings is 89.71 (10)°. In the crystal, inversion dimers linked by pairs of N—H...S hydrogen bonds occur.
Externí odkaz:
https://doaj.org/article/82926a6dd21d4fac9ba3c5bf9ecaa120
Publikováno v:
Acta Crystallographica Section E, Vol 65, Iss 11, Pp o2866-o2866 (2009)
In the title molecule, C21H16O8, the dihedral angle between the ring systems is 58.5 (1)°. In the crystal, C—H...O interactions help to establish the packing.
Externí odkaz:
https://doaj.org/article/4962523839d346f7bfe1463478f5acba
Publikováno v:
Expert Opinion on Therapeutic Patents. 32:1027-1042
Lysine-specific demethylase 1 (LSD1), which belongs to the demethylase of non-histone proteins, is believed to promote cancer cell proliferation and metastasis by modifying histones. LSD1 dysfunction may play a key role in a variety of cancers, such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08afd483dbb1ef84646b98e140ae319f
https://doi.org/10.1080/13543776.2022.2109332
https://doi.org/10.1080/13543776.2022.2109332
Publikováno v:
Pharmacology. 106:189-201
Aim: It has been reported that necrostatin-1 (Nec-1) is a specific necroptosis inhibitor that could attenuate programmed cell death induced by myocardial ischemia/reperfusion (I/R) injury. This study aimed to observe the effect and mechanism of novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7962438604596c0c4ededffa2a446ee
https://doi.org/10.1159/000510864
https://doi.org/10.1159/000510864
Publikováno v:
Drug Discovery Today. 25:568-573
As a member of the P2Y receptor family with a typical 7-transmembrane structure, P2Y6 purinergic receptor (P2Y6R) belongs to the G-protein-coupled nucleotide receptor activating the phospholipase-C signaling pathway. P2Y6R is widely involved in a ran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6aafe0b1f1ca3cad96a8468017e4f7fd
https://doi.org/10.1016/j.drudis.2019.12.015
https://doi.org/10.1016/j.drudis.2019.12.015
Autor:
Huan-Qiu Li, Chunxiao Liu, Hanwen Li, Nanxi Wang, Weiwei Wang, Duanyang Yan, Qinghua Hu, Yingxian Liu, Sheng Tian
Publikováno v:
Journal of Advanced Research
Journal of Advanced Research, Vol 23, Iss, Pp 133-142 (2020)
Journal of Advanced Research, Vol 23, Iss, Pp 133-142 (2020)
Graphical abstract
Highlights • A reliable Glide docking-based virtual screening (VS) pipeline for P2Y14R was developed. • Several potent P2Y14R antagonists with novel scaffolds were identified utilizing the VS strategy. • P2Y14R inhibitor
Highlights • A reliable Glide docking-based virtual screening (VS) pipeline for P2Y14R was developed. • Several potent P2Y14R antagonists with novel scaffolds were identified utilizing the VS strategy. • P2Y14R inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76f476d067f8c038e700b76b87c1d10d
http://europepmc.org/articles/PMC7037572
http://europepmc.org/articles/PMC7037572
Publikováno v:
Current topics in medicinal chemistry. 21(28)
Peptidomimetics are studied for medicinal application because of their ability to mimic hierarchical structures of peptides and proteins. To break the limitation and expand the peptidomimetics family, a new class of peptidomimetics based on peptide n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6621dc5e3181e7538cf8aac4909fbe05
https://pubmed.ncbi.nlm.nih.gov/34315367
https://pubmed.ncbi.nlm.nih.gov/34315367
Background and Purpose Clinical and experimental studies have shown that the sharp reduction of estrogen is one of the important reasons for the high incidence of Alzheimer’s disease (AD) in elderly women, but there is currently no such drug for tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::301c0de3bd350596389cf14d3f1e29d7
https://doi.org/10.22541/au.160271511.18429613/v1
https://doi.org/10.22541/au.160271511.18429613/v1
Autor:
Yifan Zhu, Yilin Wang, Qinghua Hu, Weiwei Wang, Huan-Qiu Li, Zhiqian Lin, Sheng Tian, Zhongkui Wang, Mengze Zhou, Yuan Huang
Publikováno v:
European Journal of Medicinal Chemistry. 227:113933
The P2Y14 nucleotide receptor, a subtype of P2Y receptors, is implicated in many human inflammatory diseases. Based on the identification of favorable residues of two screening hits in the almost symmetrical P2Y14 binding domain, we describe the stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba466507ff7f4c11fbabc21a4d156398
https://doi.org/10.1016/j.ejmech.2021.113933
https://doi.org/10.1016/j.ejmech.2021.113933