Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Huan Yi Tseng"'
Autor:
Wei-Ting Chen, Huan-Yi Tseng, Chung-Lin Jiang, Chih-Ying Lee, Peter Chi, Liuh-Yow Chen, Kai-Yin Lo, I-Ching Wang, Fu-Jung Lin
Publikováno v:
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-19 (2021)
Abstract Background RAD51-dependent homologous recombination (HR) is one of the most important pathways for repairing DNA double-strand breaks (DSBs), and its regulation is crucial to maintain genome integrity. Elp1 gene encodes IKAP/ELP1, a core sub
Externí odkaz:
https://doaj.org/article/a3c039a92bb749de84509f151dd98baf
Autor:
Kai-Yin Lo, Liuh-Yow Chen, I-Ching Wang, Wei Ting Chen, Chung-Lin Jiang, Huan-Yi Tseng, Chih-Ying Lee, Fu-Jung Lin, Peter Chi
Publikováno v:
Journal of Biomedical Science
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-19 (2021)
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-19 (2021)
Background RAD51-dependent homologous recombination (HR) is one of the most important pathways for repairing DNA double-strand breaks (DSBs), and its regulation is crucial to maintain genome integrity. Elp1 gene encodes IKAP/ELP1, a core subunit of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ec89236beaeb1742eca2d74b6e65b7
http://europepmc.org/articles/PMC8613991
http://europepmc.org/articles/PMC8613991
Autor:
Kai-Chia Yeh, Chia-Jui Lee, Jen-Shin Song, Chien-Huang Wu, Teng-Kuang Yeh, Szu-Huei Wu, Tsung-Chin Hsieh, Yen-Ting Chen, Huan-Yi Tseng, Chen-Lung Huang, Chiung-Tong Chen, Jiing-Jyh Jan, Ming-Chen Chou, Kak-Shan Shia, Kuang-Hsing Chiang
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 19; Pages: 11730
CXCR4 antagonists have been claimed to reduce mortality after myocardial infarction in myocardial infarction (MI) animals, presumably due to suppressing inflammatory responses caused by myocardial ischemia-reperfusion injury, thus, subsequently facil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14c4e017bb2221055542384ec9de728f
https://doi.org/10.3390/ijms231911730
https://doi.org/10.3390/ijms231911730
Autor:
Huan-Yi Tseng, 曾煥義
105
Genomic instability refers to an increased tendency of alterations in the genome during cell cycle progression, and likely contributes to the development of many cancers. To faithfully transmit genetic information to the progeny, efficient D
Genomic instability refers to an increased tendency of alterations in the genome during cell cycle progression, and likely contributes to the development of many cancers. To faithfully transmit genetic information to the progeny, efficient D
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/yzybc5
Autor:
Tzu Wen Lien, Jen Shin Song, Jiunn Jye Chuu, Chu Chung Lin, Chungming Chang, Heng Liang Lin, Tung Wei Chen, Der Ren Hwang, Chi Hung Lin, Tsu An Hsu, Yu-Sheng Chao, Ching Ping Chen, Chiung-Tong Chen, Huan Yi Tseng, Chen Lung Huang, Wen-Tai Li
Publikováno v:
Investigational New Drugs. 30:164-175
Designed from a high throughput screened hit compound, novel 2-amino-1-thiazolyl imidazoles were synthesized and demonstrated cytotoxicity against human cancer cells. 1-(4-Phenylthiazol-2-yl)-4-(thiophen-2-yl)-1H-imidazol-2-amine (compound 2), a 2-am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4406c1795d3e358ef5204d4268f87d5
https://doi.org/10.1007/s10637-010-9547-7
https://doi.org/10.1007/s10637-010-9547-7
Autor:
Yu-Sheng Chao, Wen-Tai Li, Chungming Chang, Ching Ping Chen, Heng Liang Lin, Hsin Sheng Wang, Chiung-Tong Chen, Chen Lung Huang, Chu Chung Lin, Chien-Chang Shen, Jen Shin Song, Chi Hung Lin, Huan Yi Tseng, Tung Wei Chen, Jiunn Jye Chuu, Der Ren Hwang, Chih Bo Hu, Chiung Yi Huang
Publikováno v:
Journal of Medicinal Chemistry. 53:2409-2417
2-Amino-1-arylidenaminoimidazoles, a novel class of orally (po) active microtubule-destabilizing anticancer agents, were synthesized. The compounds were designed from a hit compound identified in a drug discovery platform by using cancer cell-based h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4813c824d6ab69512226f2b0400c351
https://doi.org/10.1021/jm901501s
https://doi.org/10.1021/jm901501s
Autor:
Hrong-Shing Shy, Weir-Torn Jiaang, Yue-Ru Chu, Xin Chen, Chi-Min Chen, Ting-Yueh Tsai, Chih-Hsiang Huang, Hung-Kuan Tang, Yu-Sheng Chao, Yu-Chen Huang, Teng-Kuang Yeh, Huan-Yi Tseng, Yu-Lin Huang, Jia-Jing Wu, Chia-Hui Chien
Publikováno v:
Biochemical Pharmacology. 78:203-210
DPP-IV (EC 3.4.14.5) is a validated drug target for human type II diabetes. DPP-IV inhibitors without DPP8/9 inhibitory activity have been sought because a possible association has been reported between a "DPP8/9 inhibitor" and severe toxicity in ani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d618d20841bde4705bf2ffc26b4fb55
https://doi.org/10.1016/j.bcp.2009.03.032
https://doi.org/10.1016/j.bcp.2009.03.032
Autor:
Ya-Feng Shih, Po-Huang Liang, Yu-Sheng Chao, Shin-Ru Shih, Ten-Yuan Chang, Jiun-Jie Shie, Jim-Min Fang, Jin-Ching Lee, Wei-Chun Chen, Kuei-Jung Yen, Huan-Yi Tseng, John T.A. Hsu
Publikováno v:
Analytical Biochemistry. 375:115-123
Although several cell-based reporter assays have been developed for screening of viral protease inhibitors, most of these assays have a significant limitation in that numerous false positives can be generated for the compounds that are interfering wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88c11b7bc683a2dbf8b0f4aecf297314
https://doi.org/10.1016/j.ab.2007.12.019
https://doi.org/10.1016/j.ab.2007.12.019
Autor:
Yung-Ning Yang, Neeraj Mahindroo, Shao-Fang Wang, Tsu Hsu, Huan-Yi Tseng, Weir-Torn Jiaang, Ssu-Hui Wu, Wen-Hsin Huang, Shiow-Ju Lee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:2027-2032
A series of benzothiazolium compounds were identified as novel classes of inhibitors of nitric oxide production in a cell culture system. They exhibited approximately 1600 folds potency with IC(50) at approximately 50nM to several microM as compared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7754f5edfe7cca1d8577f1084d23d177
https://doi.org/10.1016/j.bmcl.2005.02.063
https://doi.org/10.1016/j.bmcl.2005.02.063
Autor:
Jyh-Haur Chern, Chih-Shiang Chang, Chia-Liang Tai, Chungming Chang, Chung-Chi Lee, Huan-Yi Tseng, Ying-Ting Lin, Yen-Chun Lee, Kak-Shan Shia
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:1169-1172
A series of 5-substituted 2-cyanoimino-4-imidazodinone and 2-cyanoimino-4-pyrimidinone derivatives were synthesized and their anticancer cytotoxicity were evaluated in in vitro assay. It was found that the bulky aryl functionality in the 5-position o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c902c224f84834153ac6a8913dad3211
https://doi.org/10.1016/j.bmcl.2003.12.073
https://doi.org/10.1016/j.bmcl.2003.12.073