Výsledky vyhledávání - "Huan Ling Liang"

Akademický článek

371 Decreased Contraction Rate, Altered Calcium Transients, and Increased Proliferation seen in Patient-specific iPSC-CMs Modeling Ebsteins Anomaly and Left Ventricular Noncompaction

Autor: Sai Suma Samudrala, Melissa Anfinson, Matthew Cavanaugh, Min-Su Kim, Peter Lamberton, Jackson Radandt, Ryan Brown, Huan Ling Liang, Karl Stamm, Afzal Zeeshan, Jennifer Strande, Michele Frommelt, John W. Lough, Robert Fitts, Michael E. Mitchell, Aoy Tomita-Mitchel

Publikováno v: Journal of Clinical and Translational Science, Vol 6, Pp 69-70 (2022)

OBJECTIVES/GOALS: In a familial case where 10 of 17 members inherited EA/LVNC in an autosomal dominant pattern, we discovered a novel, damaging missense variant in the gene KLHL26 that segregates with disease and comprises an altered electrostatic su

Externí odkaz: https://doaj.org/article/364e54d0a6cd481b8c9815acdfaff245

Zobrazit plný text záznamu

Akademický článek

Novel KLHL26 variant associated with a familial case of Ebstein’s anomaly and left ventricular noncompaction

Autor: Sai Suma K. Samudrala, Lauren M. North, Karl D. Stamm, Michael G. Earing, Michele A. Frommelt, Richard Willes, Swarnendu Tripathi, Nikita R. Dsouza, Michael T. Zimmermann, Donna K. Mahnke, Huan Ling Liang, Michael Lund, Chien‐Wei Lin, Gabrielle C. Geddes, Michael E. Mitchell, Aoy Tomita‐Mitchell

Publikováno v: Molecular Genetics & Genomic Medicine, Vol 8, Iss 4, Pp n/a-n/a (2020)

Abstract Background Ebstein's anomaly (EA) is a rare congenital heart disease of the tricuspid valve and right ventricle. Patients with EA often manifest with left ventricular noncompaction (LVNC), a cardiomyopathy. Despite implication of cardiac sar

Externí odkaz: https://doaj.org/article/ed8ad7c0a377492894678df22c9a0dbc

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Cell-free DNA donor fraction analysis in pediatric and adult heart transplant patients by multiplexed allele-specific quantitative PCR: Validation of a rapid and highly sensitive clinical test for stratification of rejection probability.

Autor: Paula E North, Emily Ziegler, Donna K Mahnke, Karl D Stamm, Angela Thomm, Paul Daft, Mary Goetsch, Huan Ling Liang, Maria Angeles Baker, Adam Vepraskas, Chris Rosenau, Mahua Dasgupta, Pippa Simpson, Michael E Mitchell, Aoy Tomita-Mitchell

Publikováno v: PLoS ONE, Vol 15, Iss 1, p e0227385 (2020)

Lifelong noninvasive rejection monitoring in heart transplant patients is a critical clinical need historically poorly met in adults and unavailable for children and infants. Cell-free DNA (cfDNA) donor-specific fraction (DF), a direct marker of sele

Externí odkaz: https://doaj.org/article/2b62faf91a274cbe8399f73a2f73357b

Zobrazit plný text záznamu

Plný text ve formátu HTML

Elevated nuclear and mitochondrial cell-free deoxyribonucleic acid measurements are associated with death after infant cardiac surgery

Autor: John P. Scott, Justinn M. Tanem, Aoy Tomita-Mitchell, George M. Hoffman, Robert A. Niebler, Huan Ling Liang, Pippa M. Simpson, Karl D. Stamm, Paula E. North, Michael E. Mitchell

Publikováno v: The Journal of Thoracic and Cardiovascular Surgery. 164:367-375

Mortality rates following pediatric cardiac surgery with cardiopulmonary bypass have declined over decades, but have plateaued in recent years. This is in part attributable to persistent issues with postoperative global inflammation and myocardial dy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c19e90ba0a8f425c152eb01271c69f18
https://doi.org/10.1016/j.jtcvs.2021.10.066

Zobrazit plný text záznamu

3D-bioprinting of patient-derived cardiac tissue models for studying congenital heart disease

Autor: Jayne T. Wolfe, Wei He, Min-Su Kim, Huan-Ling Liang, Akankshya Shradhanjali, Hilda Jurkiewicz, Bonnie P. Freudinger, Andrew S. Greene, John F. LaDisa, Lobat Tayebi, Michael E. Mitchell, Aoy Tomita-Mitchell, Brandon J. Tefft

Publikováno v: Frontiers in Cardiovascular Medicine. 10

IntroductionCongenital heart disease is the leading cause of death related to birth defects and affects 1 out of every 100 live births. Induced pluripotent stem cell technology has allowed for patient-derived cardiomyocytes to be studied in vitro. An

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aecdd2d599d646815999abba049d3419

Zobrazit plný text záznamu

Altered Contractility, Ca2+ Transients, and Cell Morphology Seen in a Patient-Specific iPSC-CM Model of Ebstein's Anomaly with Left Ventricular Noncompaction

Autor: Suma K. Thareja, Melissa Anfinson, Matthew Cavanaugh, Min-Su Kim, Peter Lamberton, Jackson Radandt, Ryan Brown, Huan-Ling Liang, Karl D. Stamm, Muhammad Zeeshan Afzal, Jennifer L. Strande, Michele A. Frommelt, John W. Lough, Robert H. Fitts, Michael E. Mitchell, Aoy Tomita-Mitchell

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology.

Patients with two congenital heart diseases (CHDs), Ebstein's anomaly (EA) and left ventricular noncompaction (LVNC), suffer higher morbidity than either CHD alone. The genetic etiology and pathogenesis of combined EA/LVNC remain largely unknown. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a16b2ef8c2f296866dcdc0e5e63ccec9
https://doi.org/10.1152/ajpheart.00658.2022

Zobrazit plný text záznamu

The novel MYH6-E1584K tail domain variant associated with hypoplastic left heart syndrome leads to hypercontractility in vitro

Autor: Melissa Anfinson, Suma Thareja, Matthew Cavanaugh, Ryan Brown, Min-Su Kim, Huan-Ling Liang, Michael Mitchell, Robert Fitts, Aoy Tomita-Mitchell

Publikováno v: Physiology. 38

Hypoplastic left heart syndrome (HLHS) is a complex form of congenital heart disease (CHD) characterized by hypoplasia of the left ventricle and proximal aorta, as well as stenosis or atresia of the mitral and aortic valves. Our lab previously identi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::714030560b9e429d9bbb8625ae7ae5b7
https://doi.org/10.1152/physiol.2023.38.s1.5733555

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání