Zobrazeno 1 - 10
of 279
pro vyhledávání: '"Huan Bao"'
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-7 (2022)
A fluorescent probe for detecting membrane protein binding and remodeling events is presented, which relies on split-GFP technology to generate circularized nanodiscs useful in membrane protein biophysics and structural biology.
Externí odkaz:
https://doaj.org/article/796c74b8637f4d739cb81fb0b4320cc4
Autor:
Shanwen Zhang, Qian Ren, Scott J. Novick, Timothy S. Strutzenberg, Patrick R. Griffin, Huan Bao
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Circularised nanodiscs (cNDs) are able to stabilise large lipid bilayer patches and are used for structural and functional studies. Current techniques to build cNDs have numerous steps and low yields; here the authors report a single step constructio
Externí odkaz:
https://doaj.org/article/abcf045a3b4d48039b28f9381ec9e24a
Autor:
Huan Bao
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-7 (2021)
Huan Bao describes nanodisc-ID which leverages nanodisc with proximity labeling, for the detection of membrane protein-lipid and protein-protein interactions. Its utility is demonstrated by characterising a wide range of integral and peripheral membr
Externí odkaz:
https://doaj.org/article/d63b64904b30433980e113e332c0581a
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
SNAREs mediate the formation of a fusion pore during exocytosis which connects the lumen of a vesicle with the extracellular space. Here, authors use single molecule approaches to define the role of synaptotagmin 1 and NSF in synaptic pore formation
Externí odkaz:
https://doaj.org/article/3f5a1f5773cd4fc6a794f2fc8bf7582b
Publikováno v:
Emergency Medicine International, Vol 2022 (2022)
Background. There are a large number of stroke patients in China, and there is currently a lack of prehospital acute stroke care training programs. Aim. To develop a prehospital emergency medical service (PEMS) training program to improve the prehosp
Externí odkaz:
https://doaj.org/article/eba6770be12a4729bff2f70fbef1b2bf
Mechanical Thrombectomy for Acute Stroke Due to Large-Vessel Occlusion Presenting With Mild Symptoms
Autor:
Feifeng Liu, Hao Shen, Chen Chen, Huan Bao, Lian Zuo, Xiahong Xu, Yumei Yang, Alexia Cochrane, Yaping Xiao, Gang Li
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Purpose: To evaluate the safety and efficacy of mechanical thrombectomy (MT) for acute stroke due to large vessel occlusion (LVO), presenting with mild symptoms.Methods: A prospective cohort study of patients with mild ischemic stroke and LVO was con
Externí odkaz:
https://doaj.org/article/983188b6e81c47a189e8bbe3b0575275
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/1ae97f1c3eb741669c1c220f5d2f67ba
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The molecular identity of the clamp that arrests the fusion machinery such that synaptic vesicles are docked and primed to release neurotransmitters remains controversial. In this study, the authors use truncation mutants of synaptotagmin (syt) 1 and
Externí odkaz:
https://doaj.org/article/60a9c376ca40470abac94a203d8f4cc1
Autor:
Limin Xu, Haifeng Ji, Yufeng Jiang, Liying Cai, Xiaoyin Lai, Feifei Wu, Rongguo Hu, Xuelian Yang, Huan Bao, Mei Jiang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
BackgroundCerebral ischemic injury is a complicated pathological process. Adipose-derived stromal cells (ADSCs) have been used as a therapeutic strategy, with their therapeutic effects chiefly attributed to paracrine action rather than trans-differen
Externí odkaz:
https://doaj.org/article/8ba503dd3ded4fe6884bcbedeac26f0f
Autor:
Berrak Ugur, Huan Bao, Michal Stawarski, Lita R. Duraine, Zhongyuan Zuo, Yong Qi Lin, G. Gregory Neely, Gregory T. Macleod, Edwin R. Chapman, Hugo J. Bellen
Publikováno v:
Cell Reports, Vol 21, Iss 13, Pp 3794-3806 (2017)
Neurotransmission is a tightly regulated Ca2+-dependent process. Upon Ca2+ influx, Synaptotagmin1 (Syt1) promotes fusion of synaptic vesicles (SVs) with the plasma membrane. This requires regulation at multiple levels, but the role of metabolites in
Externí odkaz:
https://doaj.org/article/b24801dd51874639a39d00f98dc8ed88