Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Huakan, Zhao"'
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-32 (2024)
Abstract Metabolic reprogramming drives the development of an immunosuppressive tumor microenvironment (TME) through various pathways, contributing to cancer progression and reducing the effectiveness of anticancer immunotherapy. However, our underst
Externí odkaz:
https://doaj.org/article/3b42e5bd71364a169460ec7c42977dda
Autor:
Ran Ren, Yu Chen, Yu Zhou, Luyao Shen, Yang Chen, Juan Lei, Jingchun Wang, Xudong Liu, Nan Zhang, Dongqin Zhou, Huakan Zhao, Yongsheng Li
Publikováno v:
Genes and Diseases, Vol 11, Iss 6, Pp 101281- (2024)
Dysregulated calcium (Ca2+) signaling pathways are associated with tumor cell death and drug resistance. In non-excitable cells, such as hepatocellular carcinoma (HCC) cells, the primary pathway for Ca2+ influx is through stromal interaction molecule
Externí odkaz:
https://doaj.org/article/55338671db03450bb0bf40d337b450ab
Autor:
Shuai Yang, Lu Zheng, Lingling Li, Jiangang Zhang, Jingchun Wang, Huakan Zhao, Yu Chen, Xudong Liu, Hui Gan, Junying Chen, Mei Yan, Chuanyin He, Kai Li, Chen Ding, Yongsheng Li
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 6, Pp n/a-n/a (2024)
Abstract Background The liver is anatomically divided into eight segments based on the distribution of Glisson's triad. However, the molecular mechanisms underlying each segment and its association with hepatocellular carcinoma (HCC) heterogeneity ar
Externí odkaz:
https://doaj.org/article/56c752f36b184e5cb29e5416faeb3497
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Fibroblast growth factors (FGFs) are a versatile family of peptide growth factors that are involved in various biological functions, including cell growth and differentiation, embryonic development, angiogenesis, and metabolism. Abnormal FGF/FGF rece
Externí odkaz:
https://doaj.org/article/1a5cdfaa79cc4dd5be534db534b1d897
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-25 (2023)
Abstract Mitochondria are organelles that are able to adjust and respond to different stressors and metabolic needs within a cell, showcasing their plasticity and dynamic nature. These abilities allow them to effectively coordinate various cellular f
Externí odkaz:
https://doaj.org/article/5e7a8f1b130c48639445188bea41b735
Autor:
Jingchun Wang, Qichao Xie, Lei Wu, Yu Zhou, Yanquan Xu, Yu Chen, Jiangang Zhang, Ran Ren, Shiming Yang, Yongsheng Li, Huakan Zhao
Publikováno v:
MedComm, Vol 5, Iss 2, Pp n/a-n/a (2024)
Abstract Metastasis is the leading cause of death in hepatocellular carcinoma (HCC) patients, and autophagy plays a crucial role in this process by orchestrating epithelial–mesenchymal transition (EMT). Stromal interaction molecule 1 (STIM1), a cen
Externí odkaz:
https://doaj.org/article/e9543063fa9342c086e842c4ffb8ae27
Autor:
Nan Zhang, Lei Wu, Xudong Liu, Yongsheng Li, Jiangang Zhang, Huan Deng, Juan Lei, Huakan Zhao
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 12 (2023)
Background Myeloid-derived suppressor cells (MDSCs) are crucial mediators of tumor-associated immune suppression. Targeting the accumulation and activation of MDSCs has been recognized as a promising approach to enhance the effectiveness of immunothe
Externí odkaz:
https://doaj.org/article/9af1f03a1db84656bc935f29b988e2e3
Autor:
Jiangang Zhang, Shuai Yang, Jingchun Wang, Yanquan Xu, Huakan Zhao, Juan Lei, Yu Zhou, Yu Chen, Lei Wu, Yongsheng Li
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 7, Pp 100393- (2023)
Odd-chain FAs (OCFAs) are present in very low level at nearly 1% of total FAs in human plasma, and thus, their functions were usually ignored. Recent epidemiological studies have shown that OCFAs are inversely associated with a variety of disease ris
Externí odkaz:
https://doaj.org/article/c24c2863784742e3830e99c6c1c0639c
Editorial: Macrophage immunity and metabolism in cancer: Novel diagnostic and therapeutic strategies
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/a9cba415dbc24a3ba74bfa6b2a4782b7
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-46 (2021)
Abstract Cancer development and its response to therapy are regulated by inflammation, which either promotes or suppresses tumor progression, potentially displaying opposing effects on therapeutic outcomes. Chronic inflammation facilitates tumor prog
Externí odkaz:
https://doaj.org/article/8b719e2788044119bc121919dc48980a