Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Huaji Guan"'
Autor:
Luogen Liu, Jia-Ni Yuan, Yunpeng Yang, Huaji Guan, Xiao Feng Zhu, Jueheng Wu, Junchao Cai, Mingsen Li
Publikováno v:
Biochemical and Biophysical Research Communications. 568:195
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab2daeabd9a434b26e25084ad281fcd5
https://doi.org/10.1016/j.bbrc.2021.07.010
https://doi.org/10.1016/j.bbrc.2021.07.010
Publikováno v:
European Journal of Medicinal Chemistry. 41:1167-1179
This research studied the structure-activity relationship of β-carboline derivatives as antitumor agents, in which 41 synthesized compounds and their cytotoxicity to tumor and normal cell lines were assayed. It was proved that substituent in positio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697a8bf7c7b136279bfd66219e90a915
https://doi.org/10.1016/j.ejmech.2006.05.004
https://doi.org/10.1016/j.ejmech.2006.05.004
Autor:
Xuerui Hou, Hongsheng Chen, Xiaodong Liu, Anlong Xu, Rihui Cao, Huaji Guan, Wenlie Peng, Yan Ma
Publikováno v:
Biochemical and Biophysical Research Communications. 338:1557-1563
The beta-carboline alkaloids have been characterized as a group of potential antitumor agents. The underlying mechanisms of harmine and its derivatives were investigated by DNA binding assay and Topoisomerase (Topo) inhibition assay. Meanwhile, the D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e39d5a263f4e5ee5a352f1ce64969880
https://doi.org/10.1016/j.bbrc.2005.10.121
https://doi.org/10.1016/j.bbrc.2005.10.121
Publikováno v:
European Journal of Medicinal Chemistry. 40:991-1001
To further our SAR study on the chemistry and antitumor activity/neurotoxicity of beta-carboline alkaloids, several series of beta-carboline derivatives with various substituents were designed and synthesized from the starting material l-tryptophan o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d123daa23fc3c9c80a43cdf432023fc
https://doi.org/10.1016/j.ejmech.2005.04.008
https://doi.org/10.1016/j.ejmech.2005.04.008
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:4613-4623
A series of novel 9-substituted β-carboline derivatives was synthesized from harmine and l -tryptophan, respectively. Cytotoxic activities of these compounds in vitro were investigated. The results showed that most compounds of 9-substituted β-carb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb4e131f5d69316b8ba9bd5208b958e
https://doi.org/10.1016/j.bmc.2004.06.038
https://doi.org/10.1016/j.bmc.2004.06.038
Publikováno v:
Biochemical and biophysical research communications. 342(3)
Novel 1,3,9-trisubstituted β-carboline derivatives were found to exhibit DNA photocleavage properties under visible light irradiation in a cell-free system, which could be reduced by antioxidant vitamin E. Their photo-cytotoxicity to human tumor cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af00d7c66ad02129f0c3a5c84afe946
https://pubmed.ncbi.nlm.nih.gov/16598841
https://pubmed.ncbi.nlm.nih.gov/16598841
Publikováno v:
ChemInform. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b01452b90b75e590d964be4de17537a
https://doi.org/10.1002/chin.200527149
https://doi.org/10.1002/chin.200527149
Publikováno v:
European journal of medicinal chemistry. 40(3)
A series of novel 1,3-bisubstituted and 1,3,9-trisubstituted beta-carboline derivatives was synthesized from the starting material l-tryptophan. Cytotoxic activities of these compounds were investigated in vitro. The results showed that 1,3,9-trisubs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::225ffccd80b58a20e22f236f795d6b31
https://pubmed.ncbi.nlm.nih.gov/15725494
https://pubmed.ncbi.nlm.nih.gov/15725494
Publikováno v:
BMC Biology
Background The p53 pathway is differentially activated in response to distinct DNA damage, leading to alternative phenotypic outcomes in mammalian cells. Recent evidence suggests that p53 expression dynamics play an important role in the differential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::533a87cd151b066ef336d550a2aed37a
http://europepmc.org/articles/PMC3702437
http://europepmc.org/articles/PMC3702437
Autor:
Na Shen, Gary D. Stoner, Tong Chen, Fei Yan, Zhenzhen Xu, Huaji Guan, Alexandria M. Edmonds, Ronald Nines
Publikováno v:
Cancer Research. 72:1624-1624
Esophageal squamous cell carcinoma (SCC) is one of the most common malignant neoplasms worldwide. The overall 5-year survival rate of esophageal SCC in the United States is only 13%, which is close to the observed rates in high-risk countries includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93697517765e32314e165e1e592a62ba
https://doi.org/10.1158/1538-7445.am2012-1624
https://doi.org/10.1158/1538-7445.am2012-1624