Výsledky vyhledávání - "Huai-Ping Ling"

Angiotensin IV elevates oxytocin levels in the rat amygdala and produces anxiolytic-like activity through subsequent oxytocin receptor activation

Autor: Mark Robert John, Huai-Ping Ling, Sharon Rosenzweig-Lipson, Sarah J. Neal, Jason M. Dwyer, Qian Lin, Bin Luo, Chad E. Beyer, Lee E. Schechter, Brian J. Platt

Publikováno v: Psychopharmacology. 209:303-311

The effects of angiotensin (Ang) IV result from binding to a constitutively active metallopeptidase known as the AT(4) receptor (or oxytocinase/insulin-regulated membrane aminopeptidase). While in vitro evidence indicates that Ang IV inhibits the pep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5dd26b26cc38f08edf6dacb77675c63
https://doi.org/10.1007/s00213-010-1791-1

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Ganglioside Inhibition of Neurite Outgrowth Requires Nogo Receptor Function

Autor: Gareth Williams, Ying Gao, Brian Bates, Menelas N. Pangalos, Joe Zaccardi, Frank S. Walsh, Emma-Jane Williams, Ann Aulabaugh, Yuhong Xie, Alan H. Katz, Andrew Wood, Patrick Doherty, Diane Joseph-McCarthy, Mary Lynn T. Mercado, Huai-Ping Ling

Publikováno v: Journal of Biological Chemistry. 283:16641-16652

Gangliosides are key players in neuronal inhibition, with antibody-mediated clustering of gangliosides blocking neurite outgrowth in cultures and axonal regeneration post injury. In this study we show that the ganglioside GT1b can form a complex with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19bbda366fb81b7eac74f1d3b755a467
https://doi.org/10.1074/jbc.m802067200

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Cyclic-AMP Response Element-Based Signaling Assays for Characterization of Trk Family Tyrosine Kinases Modulators

Autor: Seongeun Cho, Xiaohai Gong, Andrew W. Wood, Jie Zhang, Huai-Ping Ling, Diana Chen, Guoming Zhang, Julia Heinrich

Publikováno v: Neurosignals. 15:26-39

Neurotrophins (NTs) induce gene transcription by binding their high-affinity tropomyosin-related kinase (Trk) receptors and initiating intracellular signal transduction cascades. In particular, activation of the cyclic AMP response element (CRE) in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2389340f4bb4a3d16692ce38a5230a78
https://doi.org/10.1159/000094385

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Sodium Channel Cleavage Is Associated with Aberrant Neuronal Activity and Cognitive Deficits in a Mouse Model of Alzheimer's Disease

Autor: Steven C. Leiser, Brian F. Corbett, Jon T. Brown, Andrew Wood, Menelas N. Pangalos, Huai-Ping Ling, Andrew D. Randall, Reka Nagy, Nathalie Breysse, Anupam Hazra, Jeannie Chin, Peter H. Reinhart, Xiaohong Zhang

BACE1 is the rate-limiting enzyme that cleaves amyloid precursor protein (APP) to produce the amyloid β peptides that accumulate in Alzheimer's disease (AD). BACE1, which is elevated in AD patients and APP transgenic mice, also cleaves the β2-subun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b2b0acfd78575b8c00db53e75e8c65
https://europepmc.org/articles/PMC6618875/

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Neuroprotective profile of novel SRC kinase inhibitors in rodent models of cerebral ischemia

Autor: Frank Boschelli, Margaret M. Zaleska, Yi Chen, Shi Liang, Huai-Ping Ling, Tarek S. Mansour, Cathleen Gonzales, Kevin Pong, Menelas N. Pangalos, Robert Mark, Andrew R. Wood, Fei Ye, Philip Frost, Diane H. Boschelli, Ana Carolina Barrios Sosa

Publikováno v: The Journal of pharmacology and experimental therapeutics. 331(3)

Src kinase signaling has been implicated in multiple mechanisms of ischemic injury, including vascular endothelial growth factor (VEGF)-mediated vascular permeability that leads to vasogenic edema, a major clinical complication in stroke and brain tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299761c6cdf1fa6f540c897bea272ce9
https://pubmed.ncbi.nlm.nih.gov/19741150

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Pancortin-2 interacts with WAVE1 and Bcl-xL in a mitochondria-associated protein complex that mediates ischemic neuronal death

Autor: Mark P. Mattson, Cathleen Gonzales, Aiwu Cheng, Thiruma V. Arumugam, Rina Khatri, Huai Ping Ling, Zhihong Guo, Ouyang Xin, Khadija Mustafa, Robert J. Mark, Seung Kwak, Dong-Gyu Jo, Dong Liu

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(7)

The actin-modulating protein Wiskott-Aldrich syndrome protein verprolin homologous-1 (WAVE1) and a novel CNS-specific protein, pancortin, are highly enriched in adult cerebral cortex, but their functions are unknown. Here we show that WAVE1 and panco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7264409e22672d489498ff870dd447f2
https://pubmed.ncbi.nlm.nih.gov/17301160

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Modulation of A-type potassium channels by a family of calcium sensors

Autor: James S. Trimmer, M. Betty, Mark R. Bowlby, K. I. Mattsson, Jie Cao, Kenneth J. Rhodes, Brian W. Strassle, J. W. Hinson, G. Mendoza, Huai-ping Ling, An Wenqian

Publikováno v: Nature. 403(6769)

In the brain and heart, rapidly inactivating (A-type) voltage-gated potassium (Kv) currents operate at subthreshold membrane potentials to control the excitability of neurons and cardiac myocytes. Although pore-forming alpha-subunits of the Kv4, or S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::438cf29f5688d628742b77bdbb9272fe
https://pubmed.ncbi.nlm.nih.gov/10676964

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Cloning and expression of the human kv4.3 potassium channel

Autor: Huai-Ping Ling, Patricia Tyson Sokol, Mark I. Cockett, Daniel Wayne Dilks, Randy Numann

Publikováno v: Journal of neurophysiology. 81(4)

Cloning and expression of the human Kv4.3 potassium channel. We report on the cloning and expression of hKv4.3, a fast inactivating, transient, A-type potassium channel found in both heart and brain that is 91% homologous to the rat Kv4.3 channel. Tw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9125882307d2bca8eba72faa92deb31b
https://pubmed.ncbi.nlm.nih.gov/10200233

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