Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Huai-Kuang Tsai"'
Publikováno v:
BMC Genomics, Vol 25, Iss S3, Pp 1-16 (2024)
Abstract Background Alternative splicing is a pivotal mechanism of post-transcriptional modification that contributes to the transcriptome plasticity and proteome diversity in metazoan cells. Although many splicing regulations around the exon/intron
Externí odkaz:
https://doaj.org/article/98ad9acef61a48188f47e2223ca9c95a
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106635- (2023)
Summary: Enhanced phenotypic diversity increases a population’s likelihood of surviving catastrophic conditions. Hsp90, an essential molecular chaperone and a central network hub in eukaryotes, has been observed to suppress or enhance the effects o
Externí odkaz:
https://doaj.org/article/9631e5b7d50449fd892a89d5e4d90d60
Publikováno v:
BMC Genomics, Vol 22, Iss S5, Pp 1-12 (2022)
Abstract Background Alternative splicing (AS) increases the diversity of transcriptome and could fine-tune the function of genes, so that understanding the regulation of AS is vital. AS could be regulated by many different cis-regulatory elements, su
Externí odkaz:
https://doaj.org/article/ec614264bbc646be9a9604f68c305974
Publikováno v:
BMC Genomics, Vol 22, Iss S5, Pp 1-14 (2022)
Abstract Background Many long non-coding RNAs (lncRNAs) have been extensively identified in higher eukaryotic species. The function of lncRNAs has been reported to play important roles in diverse biological processes, including developmental regulati
Externí odkaz:
https://doaj.org/article/bd8b6e5f8a3842aba21a5e048ff2dc6b
Autor:
Wei-Liang Liu, Chia-Wei Hsu, Shih-Peng Chan, Pei-Shi Yen, Matthew P. Su, Jian-Chiuan Li, Hsing-Han Li, Lie Cheng, Cheng-Kang Tang, Shih-Hsun Ko, Huai-Kuang Tsai, Zing Tsung-Yeh Tsai, Omar S. Akbari, Anna-Bella Failoux, Chun-Hong Chen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract The areas where dengue virus (DENV) is endemic have expanded rapidly, driven in part by the global spread of Aedes species, which act as disease vectors. DENV replicates in the mosquito midgut and is disseminated to the mosquito’s salivary
Externí odkaz:
https://doaj.org/article/19c406fe30f44c4fa7c547a6dc2d179e
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Ko-Han Lee et al. develop MHCfovea, a machine-learning method for predicting peptide-binding by MHC molecules and inferring peptide motifs and MHC allele signatures. They demonstrate that MHCfovea is capable of detecting meaningful hyper-motifs and a
Externí odkaz:
https://doaj.org/article/45cf54d9491b4a21ba51557d146c6f41
Autor:
Shin Yen Chong, Sam Cutler, Jing-Jer Lin, Cheng-Hung Tsai, Huai-Kuang Tsai, Sue Biggins, Toshio Tsukiyama, Yi-Chen Lo, Cheng-Fu Kao
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Transcription-replication conflicts (TRC) can contribute to genome instability. Here the authors reveal that under replication stress H3K4 methylation can play a role in TRC prevention.
Externí odkaz:
https://doaj.org/article/03614e9236ea440180cb45b738186f2e
Autor:
Wei-Liang Liu, Chia-Wei Hsu, Shih-Peng Chan, Pei-Shi Yen, Matthew P. Su, Jian-Chiuan Li, Hsing-Han Li, Lie Cheng, Cheng-Kang Tang, Shih-Hsun Ko, Huai-Kuang Tsai, Zing Tsung-Yeh Tsai, Omar S. Akbari, Anna-Bella Failloux, Chun-Hong Chen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/c69e1ad67d484f66b71365ec252e44eb
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-8 (2017)
Abstract Background The regulatory roles of long intergenic noncoding RNAs (lincRNAs) in humans have been revealed through the use of advanced sequencing technology. Recently, three possible scenarios of lincRNA origins have been proposed: de novo or
Externí odkaz:
https://doaj.org/article/045e4bd5794a45adb97b3482aa8d5a37
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
Changes in cis-regulatory DNA sequences and transcription factor (TF) repertoires provide major sources of phenotypic diversity that shape the evolution of gene regulation in eukaryotes. The DNA-binding specificities of TFs may be diversified or prod
Externí odkaz:
https://doaj.org/article/5602c23704c84bdf9b545bbbdcf1de31