Výsledky vyhledávání - "Huai Chin Chiang"

Akademický článek

A highly selective humanized DDR1 mAb reverses immune exclusion by disrupting collagen fiber alignment in breast cancer

Autor: Rong Li, Ningyan Zhang, Zhiqiang An, Wei Xiong, Huai-Chin Chiang, Hui Deng, Junquan Liu, Victor Laurent, Samuel C Griffiths, Jasmin Dülfer, Xiujie Sun, Y Whitney Yin, Wenliang Li, Laurent P Audoly, Thomas Schürpf

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 6 (2023)

Background Immune exclusion (IE) where tumors deter the infiltration of immune cells into the tumor microenvironment has emerged as a key mechanism underlying immunotherapy resistance. We recently reported a novel role of discoidin domain-containing

Externí odkaz: https://doaj.org/article/3537ca4000574c579032deb0a579a11b

Zobrazit plný text záznamu

Akademický článek

RNA polymerase II pausing factor NELF in CD8+ T cells promotes antitumor immunity

Autor: Bogang Wu, Xiaowen Zhang, Huai-Chin Chiang, Haihui Pan, Bin Yuan, Payal Mitra, Leilei Qi, Hayk Simonyan, Colin N. Young, Eric Yvon, Yanfen Hu, Nu Zhang, Rong Li

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

Negative elongation factor B (NELFB) is one of the four subunits of the NELF complex that controls RNA polymerase II pausing. Here the authors show that, by associating with the key T cell transcription factor TCF1, NELFB is required for eliciting CD

Externí odkaz: https://doaj.org/article/2778d1c82b674868ad6b34ca40a859a4

Zobrazit plný text záznamu

Akademický článek

BRCA1 deficiency in mature CD8+ T lymphocytes impairs antitumor immunity

Autor: Rong Li, Xiaowen Zhang, Bogang Wu, Yanfen Hu, Anelia Horvath, Claudine Isaacs, Yidong Chen, Leilei Qi, Huai-Chin Chiang, Haihui Pan, Alexandra Greenbaum, Elizabeth Stark, Li-Ju Wang, Bassem R. Haddad, Dionyssia Clagett, Richard Elledge

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 2 (2023)

Women with BRCA1 germline mutations have approximately an 80% lifetime chance of developing breast cancer. While the tumor suppressor function of BRCA1 in breast epithelium has been studied extensively, it is not clear whether BRCA1 deficiency in non

Externí odkaz: https://doaj.org/article/eb98d1b26ddb49bfbcad17cbfb1f7623

Zobrazit plný text záznamu

Akademický článek

R-loop functions in Brca1-associated mammary tumorigenesis.

Autor: Huai-Chin Chiang, Leilei Qi, Payal Mitra, Yimeng Huang, Yanfen Hu, Rong Li

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America; 8/13/2024, Vol. 121 Issue 33, p1-8, 17p

Zobrazit plný text záznamu

Akademický článek

BRCA1 mutations attenuate super-enhancer function and chromatin looping in haploinsufficient human breast epithelial cells

Autor: Xiaowen Zhang, Yao Wang, Huai-Chin Chiang, Yuan-Pang Hsieh, Chang Lu, Ben Ho Park, Ismail Jatoi, Victor X. Jin, Yanfen Hu, Rong Li

Publikováno v: Breast Cancer Research, Vol 21, Iss 1, Pp 1-15 (2019)

Abstract Background BRCA1-associated breast cancer originates from luminal progenitor cells. BRCA1 functions in multiple biological processes, including double-strand break repair, replication stress suppression, transcriptional regulation, and chrom

Externí odkaz: https://doaj.org/article/042a6dab948c48aea42c5a8108d1a883

Zobrazit plný text záznamu

Akademický článek

Genetic ablation of adipocyte PD-L1 reduces tumor growth but accentuates obesity-associated inflammation

Autor: Rong Li, Bin Yuan, Bogang Wu, Yanfen Hu, Tyler J Curiel, Huai-Chin Chiang, Xiujie Sun, Payal Mitra

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)

The programmed death-ligand 1 (PD-L1)-dependent immune checkpoint attenuates host immunity and maintains self-tolerance. Imbalance between protective immunity and immunopathology due to altered PD-L1 signaling can lead to autoimmunity or tumor immuno

Externí odkaz: https://doaj.org/article/e4793b49487a45ad8664d5c4cfef8955

Zobrazit plný text záznamu

Akademický článek

Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)

The vast majority of BRCA1-driven breast cancers derive from luminal progenitor cells but the mechanisms of this lineage specificity are unclear. Here the authors show that dangerous accumulation of DNA-RNA hybrid structures due to RNA polymerase II

Externí odkaz: https://doaj.org/article/38cac16b041a40679c30545eb63c3763

Zobrazit plný text záznamu

Akademický článek

Genetic suppression reveals DNA repair-independent antagonism between BRCA1 and COBRA1 in mammary gland development

Autor: Sreejith J. Nair, Xiaowen Zhang, Huai-Chin Chiang, Md Jamiul Jahid, Yao Wang, Paula Garza, Craig April, Neeraj Salathia, Tapahsama Banerjee, Fahad S. Alenazi, Jianhua Ruan, Jian-Bing Fan, Jeffrey D. Parvin, Victor X. Jin, Yanfen Hu, Rong Li

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)

COBRA1 is a BRCA1-binding protein and, as part of the negative elongation factor, regulates RNA polymerase II pausing and transcription elongation. Here, the authors show that tissue-specific deletion of mouse Cobra1 inhibits postnatal mammary gland

Externí odkaz: https://doaj.org/article/e8b1af6dbaf6435f9056729025693328

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání