Zobrazeno 1 - 10
of 214
pro vyhledávání: '"Huai‐Dong Song"'
Autor:
Ya Fang, Jia-Ping Wan, Zheng Wang, Shi-Yang Song, Cao-Xu Zhang, Liu Yang, Qian-Yue Zhang, Chen-Yan Yan, Feng-Yao Wu, Sang-Yu Lu, Feng Sun, Bing Han, Shuang-Xia Zhao, Mei Dong, Huai-Dong Song
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The mechanisms of bifurcation, a key step in thyroid development, are largely unknown. Here we find three zebrafish lines from a forward genetic screening with similar thyroid dysgenesis phenotypes and identify a stop-gain mutation in hgfa a
Externí odkaz:
https://doaj.org/article/03b13e80251642c59ec1b2d152a4907c
Autor:
Rui-Meng Yang, Shi-Yang Song, Feng-Yao Wu, Rui-Feng Yang, Yan-Ting Shen, Ping-Hui Tu, Zheng Wang, Jun-Xiu Zhang, Feng Cheng, Guan-Qi Gao, Jun Liang, Miao-Miao Guo, Liu Yang, Yi Zhou, Shuang-Xia Zhao, Ming Zhan, Huai-Dong Song
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The pathogenesis of thyroid dysgenesis (TD) is not well understood. Here, using a combination of single-cell RNA and spatial transcriptome sequencing, we identify a subgroup of NF-κB-activated thyrocytes located at the center of thyroid tis
Externí odkaz:
https://doaj.org/article/de96cbfe3add49e090d84426e4f595ec
Autor:
Liu Yang, Ping-hui Tu, Cao-xu Zhang, Rong-rong Xie, Mei Dong, Yu Jing, Xia Chen, Gang Wei, Huai-dong Song
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionIn recent years, the potential toxicities of different pharmaceuticals toward the thyroid system have received increasing attention. In this study, we aim to evaluate the toxic effects of pazopanib and axitinib, two anti-tumor drugs with
Externí odkaz:
https://doaj.org/article/e0389ad2d4e74a4782571d82c37936fc
Autor:
Chen-Yan Yan, Feng-Yao Wu, Feng Sun, Ya Fang, Rui-Jia Zhang, Chang-Run Zhang, Cao-Xu Zhang, Zheng Wang, Rui-Meng Yang, Liu Yang, Mei Dong, Qian-Yue Zhang, Xiao-Ping Ye, Huai-Dong Song, Shuang-Xia Zhao
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
BackgroundISL LIM homeobox 2, also known as insulin gene enhancer protein ISL-2 (ISL2), is a transcription factor gene that participates in a wide range of developmental events. However, the role of ISL2 in the hypothalamus-pituitary-thyroid axis is
Externí odkaz:
https://doaj.org/article/7a8f1f2241c245beb06b935adfe28b4e
Autor:
Chang-Run Zhang, Yuan-Ping Shi, Cao-Xu Zhang, Feng Sun, Wen-Jiao Zhu, Rui-Jia Zhang, Ya Fang, Qian-Yue Zhang, Chen-Yan Yan, Ying-Xia Ying, Shuang-Xia Zhao, Huai-Dong Song
Publikováno v:
JCRPE, Vol 14, Iss 1, Pp 46-55 (2022)
INTRODUCTION: Defects in the human solute carrier family 26 member 4 (SLC26A4) gene are reported to be one of the causes of congenital hypothyroidism (CH). We aimed to identify SLC26A4 mutations in Chinese patients with CH and analyze the function of
Externí odkaz:
https://doaj.org/article/22c7539fc88e49b983236c3e31d4840f
Autor:
Qian-Yue Zhang, Xiao-Ping Ye, Zheng Zhou, Chen-Fang Zhu, Rui Li, Ya Fang, Rui-Jia Zhang, Lu Li, Wei Liu, Zheng Wang, Shi-Yang Song, Sang-Yu Lu, Shuang-Xia Zhao, Jian-Nan Lin, Huai-Dong Song
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Hashimoto’s Thyroiditis is an autoimmune disease with a complex pathomechanism. Authors here show by single cell RNA sequencing that the thyroidal microenvironment in the disease is characterised by three stromal cell subtypes that are potentially
Externí odkaz:
https://doaj.org/article/9efe0aed643e40f0a6d940fc628988fe
Publikováno v:
BMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-9 (2021)
Abstract Background Graves’ disease (GD) is one of the most common autoimmune thyroid diseases (AITDs) in humans, and thyrotropin receptor antibody (TRAb) is a characterized autoantibody in GD. The use of radioactive iodine therapy (RAI) for GD tre
Externí odkaz:
https://doaj.org/article/50b78bfb6f954331bf89381fdb3afc5a
Publikováno v:
FEBS Open Bio, Vol 11, Iss 5, Pp 1417-1427 (2021)
Thyroid dysgenesis (TD) is a major cause of primary congenital hypothyroidism; however, the molecular mechanism underlying this process is unclear. Current knowledge regarding the morphogenesis of the thyroid gland and vascular anomalies affecting th
Externí odkaz:
https://doaj.org/article/838de6c83ebe4a86bc81e55620d6d64e
Autor:
Sang-Yu Lu, Ying-Chao Chen, Jia-Lin Feng, Qin-Yi Zhou, Jing Chen, Chen-Fang Zhu, Miao-Miao Guo, Man-Man Zhang, Qian-Yue Zhang, Meng Lu, Liu Yang, Jing Wu, Shuang-Xia Zhao, Huai-Dong Song, Xiao-Ping Ye
Publikováno v:
International Journal of Endocrinology, Vol 2022 (2022)
Background. BRAF exon 15 p.V600E (BRAF V600E) mutation has been established as an important molecular marker for papillary thyroid carcinoma diagnosis by ultrasound-guided fine-needle aspiration biopsy (FNAB). Sanger sequencing is the gold standard f
Externí odkaz:
https://doaj.org/article/70cff3e2d5d24d968ae59897199e6d94
Autor:
He Jiang, Fei-Fei Yuan, Hai-Ning Wang, Wei Liu, Xiao-Ping Ye, Shao-Ying Yang, Hui-Jun Xie, Sha-Sha Yu, Yu-Ru Ma, Le-Le Zhang, Shuang-Xia Zhao, Huai-Dong Song, The China Consortium for the Genetics of Autoimmune Thyroid Disease
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Mutations in CD40 have been widely reported to be risk factors for Graves’ disease (GD). The gene, along with its cognate ligand CD40L, may regulate pro-inflammatory and immune responses. Rs1883832, located at the -1 position of the Kozak sequence,
Externí odkaz:
https://doaj.org/article/cf205bfd803540a3a5e7d83459702134