Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Huagang, Lu"'
Autor:
Yan Xu, Miglena Prabagar, Ku Lu, Rukiye-Nazan Eraslan, Albert Uveges, Jason Trama, Rachael Siegel, Stan Nawoschik, Michael McQueney, Grant Gallagher, Venu Bommireddy, Jim Beasley, Jane Wu, William Solvibile, Steven Paget, Daniel Miller, Brian McGuinness, Brett Marinelli, Huagang Lu, David Kaelin, Chia-Yu Huang, Audrey Hospital, David Diller, Axel Metzger
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36fa335acea9c7eb796a7401ab35c2f6
https://doi.org/10.1021/scimeetings.1c00291
https://doi.org/10.1021/scimeetings.1c00291
Autor:
William A. Kinney, Julia Ma, Shuo Wu, Jinhong Chang, Ju-Tao Guo, Huagang Lu, Xuexiang Zhang, Fang Guo, Yanming Du, Zhengyin Yan, Katherine Yang, Jia Guo, Lam Patrick Y S, Qing Su, Timothy M. Block, Yu-Huan Li
IHVR-19029 (6) is a lead endoplasmic reticulum α-glucosidases I and II inhibitor, which efficiently protected mice from lethal Ebola and Marburg virus infections via injection route, but suffered from low bioavailability and off-target interactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eafa3e94f6be75720f74dd0e12518b8
https://europepmc.org/articles/PMC5304290/
https://europepmc.org/articles/PMC5304290/
Autor:
David Wilson, Bindhu V. Karanam, Mona Purcell, Maria Madeira, Gary G. Chicchi, Jianming Bao, Liza Gantert, Robert J. DeVita, Huagang Lu, Wai-Si Eng, Sander G. Mills, Richard G. Ball, Andrew J. Kassick, Peter Lin, Sanjeev Kumar, Jaime Lynn Bunda, George A. Doss, Kwei-Lan C. Tsao, Jacquelyn J. Cook, Xinchun Tong, Richard Tschirret-Guth, Jinlong Jiang, Koppara Samuel, Richard Hargreaves, Hong Wang, Donald F. Hora
Publikováno v:
Journal of Medicinal Chemistry. 56:5940-5948
Hydroisoindoline 2 has been previously identified as a potent, brain-penetrant NK1 receptor antagonist with a long duration of action and improved profile of CYP3A4 inhibition and induction compared to aprepitant. However, compound 2 is predicted, ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94febe29ddadade1fbafbe0e7e0c71d3
https://doi.org/10.1021/jm400751p
https://doi.org/10.1021/jm400751p
Autor:
Andrew J, Kassick, Jinlong, Jiang, Jaime, Bunda, David, Wilson, Jianming, Bao, Huagang, Lu, Peter, Lin, Richard G, Ball, George A, Doss, Xinchun, Tong, Kwei-Lan C, Tsao, Hong, Wang, Gary, Chicchi, Bindhu, Karanam, Richard, Tschirret-Guth, Koppara, Samuel, Donald F, Hora, Sanjeev, Kumar, Maria, Madeira, Waisi, Eng, Richard, Hargreaves, Mona, Purcell, Liza, Gantert, Jacquelyn, Cook, Robert J, DeVita, Sander G, Mills
Publikováno v:
Journal of medicinal chemistry. 56(14)
Hydroisoindoline 2 has been previously identified as a potent, brain-penetrant NK1 receptor antagonist with a long duration of action and improved profile of CYP3A4 inhibition and induction compared to aprepitant. However, compound 2 is predicted, ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b81957365353e94734b4df68ad567f3d
https://pubmed.ncbi.nlm.nih.gov/23808489
https://pubmed.ncbi.nlm.nih.gov/23808489
Autor:
Gary G. Chicchi, Kwei-Lan C. Tsao, Huagang Lu, Xinchun Tong, Gregori J. Morriello, Robert J. DeVita, Alan Wheeldon, Emma J. Carlson, Sander G. Mills, Song Zheng, Jianming Bao, Marc M. Kurtz
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(7)
A new class of potent NK1 receptor antagonists with a tetrahydroindolizinone core has been identified. This series of compounds demonstrated improved functional activities as compared to previously identified 5,5-fused pyrrolidine lead structures. SA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f528cd8177c783967c22911a6cf6d1ce
https://pubmed.ncbi.nlm.nih.gov/20188553
https://pubmed.ncbi.nlm.nih.gov/20188553
Autor:
Shigeki Nakagawa, John Rogowskyj, Xiaodong Xu, William A. Kinney, Nicolas Goossens, Takaaki Higashi, Anu Venkatesh, Yujin Hoshida, Timothy M. Block, Huagang Lu, Spiros P. Hiotis, Myron E. Schwarz, Anna P. Koh, Yanming Du, Noshena Khan, Ganesh Gunasekaran, Andrea Cuconati, Wenquan Yu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Based on our previous identification of a disubstituted aminothiazole termed HBF-0079 with promising selective toxicity for HCC-derived cell lines versus non-HCC liver lines, a series of tri-substituted aminothiazole derivatives were prepared and eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1352a1d1fdaf504edf2638b3f5dd19d0