Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Huafei Zou"'
Autor:
Sang Jun Lee, Madhupriya Mahankali, Abdallah Bitar, Huafei Zou, Elizabeth Chao, Hung Nguyen, Jose Gonzalez, Dawna Caballero, Mitch Hull, Danling Wang, Peter G. Schultz, Weijun Shen
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Elevated triglyceride (TG) levels are well-correlated with the risk for cardiovascular disease (CVD). Apolipoprotein CIII (ApoC-III) is a key regulator of plasma TG levels through regulation of lipolysis and lipid synthesis. To identify nove
Externí odkaz:
https://doaj.org/article/3ea9011fb70b4cf78139664545c9293e
Autor:
Sam Lear, Hyosuk Seo, Candy Lee, Lei Lei, Zaid Amso, David Huang, Huafei Zou, Zhihong Zhou, Vân T. B. Nguyen-Tran, Weijun Shen
Publikováno v:
Molecules, Vol 25, Iss 11, p 2508 (2020)
Owing to their pleiotropic metabolic benefits, glucagon-like peptide-1 receptor (GLP-1R) agonists have been successfully utilized for treating metabolic diseases, such as type 2 diabetes and obesity. As part of our efforts in developing long-acting p
Externí odkaz:
https://doaj.org/article/0f8f57e89c634252b0144a04b6523bf1
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39379 (2012)
Caveolin-1, the structural protein component of caveolae, acts as a scaffolding protein that functionally regulates signaling molecules. We show that knockdown of caveolin-1 protein expression enhances chemotherapeutic drug-induced apoptosis and inhi
Externí odkaz:
https://doaj.org/article/0ab4a5bf68ca477ab4a814cbb4df01f8
Publikováno v:
PLoS ONE, Vol 7, Iss 9 (2012)
Externí odkaz:
https://doaj.org/article/fd4ea9e261c542728efa8cea40ba81d2
Autor:
Lu-Yuan Li, Patrick Y. Lu, A. James Mixson, Jennifer R. Grandis, Fang Tian, Huafei Zou, Zhenwen Yan
The rhomboid family of genes carry out a wide range of important functions in a variety of organisms. Little is known, however, about the function of the human rhomboid family-1 gene (RHBDF1). We show here that RHBDF1 function is essential to epithel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e18710e758fa1bfdc70b95c6b0f302
https://doi.org/10.1158/1535-7163.c.6531672
https://doi.org/10.1158/1535-7163.c.6531672
Autor:
Lu-Yuan Li, Patrick Y. Lu, A. James Mixson, Jennifer R. Grandis, Fang Tian, Huafei Zou, Zhenwen Yan
Supplementary Fig. S1 from Human rhomboid family-1 gene silencing causes apoptosis or autophagy to epithelial cancer cells and inhibits xenograft tumor growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bad00efdff9b6ecbb2d987ac997a0e2
https://doi.org/10.1158/1535-7163.22484949
https://doi.org/10.1158/1535-7163.22484949
Autor:
Weijun Shen, Vân T B Nguyen-Tran, David Huang, Zaid Amso, Peng-Yu Yang, Candy Lee, Huafei Zou, Ashley K. Woods, Peter G. Schultz
Publikováno v:
Bioconjugate Chemistry. 31:1167-1176
Oxyntomodulin (OXM) is an intestinal peptide hormone that activates both glucagon-like peptide-1 (GLP-1) and glucagon (GCG) receptors. The natural peptide reduces body weight in obese subjects and exhibits direct acute glucoregulatory effects in pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f736b2f9eb7492a8a522c7df8c00672
https://doi.org/10.1021/acs.bioconjchem.0c00093
https://doi.org/10.1021/acs.bioconjchem.0c00093
Autor:
Matthew S. Tremblay, Huafei Zou, Shan Yu, Van Nguyen-Tran, Candy Lee, Elsa Pflimlin, Andrew To, Sam Lear, Sean B. Joseph, Weijun Shen
Publikováno v:
ACS Med Chem Lett
[Image: see text] Anorexigenic peptides offer promise as potential therapies targeting the escalating global obesity epidemic. Prolactin-releasing peptide (PrRP), a novel member of the RFamide family secreted by the hypothalamus, shows therapeutic po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b91281208b5d2e2fb449e1c36acb9b09
https://doi.org/10.1021/acsmedchemlett.9b00182
https://doi.org/10.1021/acsmedchemlett.9b00182
Publikováno v:
Tetrahedron. 75:286-295
A panel of three lipid-modified, functionalized biphenyl cross-linkers (fBph) were synthesized and subsequently employed in the preparation of the stapled oxyntomodulin (OXM) analogs. In a luciferase-based reporter assay, these stapled OXM analogs sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbe81b95b99b90d6358cb8a2a458d7b9
https://doi.org/10.1016/j.tet.2018.11.060
https://doi.org/10.1016/j.tet.2018.11.060
Autor:
Avinash Muppidi, Weijun Shen, Peter G. Schultz, Huafei Zou, Qiangwei Fu, Danling Wang, Elizabeth Chao, Peng-Yu Yang, Candy Lee, Xiaozhou Luo
Publikováno v:
Journal of Medicinal Chemistry. 61:3218-3223
Glucagon-like peptide 2 (GLP-2) is a hormone that has been shown to stimulate intestinal growth and attenuate intestinal inflammation. Despite being efficacious in a variety of animal models of disease, its therapeutic potential is hampered by the sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97f9ff916e7b86d9c83032be05a1d658
https://doi.org/10.1021/acs.jmedchem.7b00768
https://doi.org/10.1021/acs.jmedchem.7b00768