Výsledky vyhledávání - "Huachao, Bin"

Akademický článek

Non-classical ferroptosis inhibition by a small molecule targeting PHB2

Autor: Wei Yang, Bo Mu, Jing You, Chenyu Tian, Huachao Bin, Zhiqiang Xu, Liting Zhang, Ronggang Ma, Ming Wu, Guo Zhang, Chong Huang, Linli Li, Zhenhua Shao, Lunzhi Dai, Laurent Désaubry, Shengyong Yang

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Ferroptosis is a promising therapeutic target for a variety of diseases, but a majority of known ferroptosis inhibitors belong to either antioxidants or iron chelators. Here, the authors discover a new non-classical small molecule inhibitor that is a

Externí odkaz: https://doaj.org/article/5bae468ec3a34502ae52c86217dd6b9b

Zobrazit plný text záznamu

Structural Optimization and Structure–Activity Relationship Studies of 6,6-Dimethyl-4-(phenylamino)-6H-pyrimido[5,4-b][1,4]oxazin-7(8H)-one Derivatives as A New Class of Potent Inhibitors of Pan-Trk and Their Drug-Resistant Mutants

Autor: Shulei Pan, Liting Zhang, Xinling Luo, Jinshan Nan, Wei Yang, Huachao Bin, Yang Li, Qiao Huang, Tianqi Wang, Zhiling Pan, Bo Mu, Falu Wang, Chenyu Tian, Yang Liu, Linli Li, Shengyong Yang

Publikováno v: Journal of Medicinal Chemistry. 65:2035-2058

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85e79da9d0147c232dd4e6303617f7be
https://doi.org/10.1021/acs.jmedchem.1c01597

Zobrazit plný text záznamu

Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis

Autor: Yan Jiao, Jinshan Nan, Bo Mu, Yun Zhang, Nenghua Zhou, Shunhua Yang, Shanshan Zhang, Wanting Lin, Falu Wang, Anjie Xia, Zhixing Cao, Pei Chen, Zhiling Pan, Guifeng Lin, Shulei Pan, Huachao Bin, Linli Li, Shengyong Yang

Publikováno v: European journal of medicinal chemistry. 232

The NLRP3 inflammasome, which regulated a proinflammatory programmed cell death form termed pyroptosis, is involved in the pathological process of various human diseases, such as multiple sclerosis, type 2 diabetes, and gout. Thus, compounds inhibiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae3b9a3b5bbcd266475ddd517fa35f43
https://pubmed.ncbi.nlm.nih.gov/35183871

Zobrazit plný text záznamu

Discovery of 6,7-dihydro-5H-pyrrolo[3,4-d] pyrimidine derivatives as a new class of ATR inhibitors

Autor: Pei, Chen, Huachao, Bin, Yan, Jiao, Guifeng, Lin, Yun, Zhang, Anjie, Xia, Zhilin, Pan, Jingxin, Qiao, Yinping, Guo, Jingming, Liu, Yangli, Zhou, Linli, Li

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 63:128651

Ataxia telangiectasia and Rad3-related (ATR) kinase is a key regulating protein within the DNA damage response (DDR), responsible for sensing replication stress (RS), and has been considered as a potential target for cancer therapy. Herein, we report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adaa9dff048cffae3c1b880f3f0b6ec6
https://doi.org/10.1016/j.bmcl.2022.128651

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání