Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Huabing Sun"'
Autor:
Jinyan Chai, Mengxue Su, Ruiguo Zhang, Ning Li, Yuanyuan Jia, Wei Zheng, Jian Tan, Qiang Jia, Huabing Sun, Zhaowei Meng
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Anaplastic thyroid carcinoma (ATC) is a rare but highly aggressive thyroid cancer with poor prognosis. Killing cancer cells by inducing DNA damage or blockage of DNA repair is a promising strategy for chemotherapy. It is reported that aldehy
Externí odkaz:
https://doaj.org/article/a491a408fc944fe2adfc4ab8a68fad1c
Publikováno v:
Heliyon, Vol 10, Iss 14, Pp e34291- (2024)
Anaplastic thyroid carcinoma is one of the highly fatal cancers and poses a serious threat to human health. Ferroptosis has been widely studied and proved to have an important role in tumor suppression, providing new avenues for cancer therapy; gluta
Externí odkaz:
https://doaj.org/article/cf653e4aef974c9881109fc8833904fc
Publikováno v:
ACS Omega, Vol 4, Iss 3, Pp 5107-5116 (2019)
Externí odkaz:
https://doaj.org/article/e736cf587cc4477f8b732e0200310ea8
Autor:
Li Xue, Dehao Yu, Jing Sun, Liangyu Guan, Chengzhi Xie, Luo Wang, Yuanyuan Jia, Junyu Tian, Heli Fan, Huabing Sun
Publikováno v:
The Analyst. 148:532-538
Biothiols play essential roles in balancing the redox state and modulating cellular functions. Fluorescent probes for monitoring/labelling biothiols often suffer from slow reaction rates, strong background fluorescence and cytotoxic byproduct release
Autor:
Yongjian Ma, Xuzichao Li, Feng Wang, Lingling Zhang, Xing Che, Dehao Yu, Xiang Liu, Zhuang Li, Huabing Sun, Guimei Yu, Heng Zhang
Plant-associated bacteria play important regulatory roles in modulating plant hormone auxin levels, affecting the growth and yields of crops. A conserved auxin-degradation (adg) operon was recently identified in theVariovoraxgenomes, which is respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9859ff4733a70684bb3f482f87cc5df7
https://doi.org/10.1101/2022.11.01.514793
https://doi.org/10.1101/2022.11.01.514793
Publikováno v:
Bioorganic chemistry. 130
Arylboronic acid/esters and phenyl selenides-based quinone methide (QM) precursors were reported to induce DNA interstrand crosslink (ICL) formation upon reaction with the inherently high concentrations of H
Publikováno v:
Chemistry – A European Journal. 27:5215-5224
Two series of 1,1'-biphenyl analogues with various leaving groups (L = OAc, OCH 3 , OCHCH=CH 2 , OCH 2 Ph, SPh, SePh, and Ph 3 P + ) were synthesized. Their reactivity towards DNA and the reaction mechanism were investigated by determining DNA inters
Autor:
Li Xue, Dehao Yu, Lingling Wang, Jing Sun, Ying Song, Yuanyuan Jia, Ang Wu, Beibei Zhang, Wenyi Mi, Heli Fan, Huabing Sun
Publikováno v:
ACS chemical biology. 17(4)
Abasic (AP) sites are one of the most common DNA lesions in cells. Aldehyde-reactive alkoxyamines capture AP sites and block the activity of APE1, the enzyme responsible for initiating their repair. Blocking the APE1 repair of AP sites leads to cell
Publikováno v:
Chembiochem : a European journal of chemical biology. 23(7)
DNA interstrand crosslinks (ICLs) are highly toxic DNA lesions, and induce cell death by blocking DNA strand separation. Most ICL agents aiming to kill cancer cells, also generate adverse side effects to normal cells. H
Publikováno v:
ACS Omega, Vol 4, Iss 3, Pp 5107-5116 (2019)
Previous reports showed that consecutive incorporations of triazole-modified 2′-deoxyuridines stabilized DNA·DNA and DNA·RNA duplexes due to additional π-stacking between triazole moieties. In this...