Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Hua-bing Li"'
Publikováno v:
RNA Biology, Vol 20, Iss 1, Pp 603-613 (2023)
RNA modifications play a vital role in multiple pathways of mRNA metabolism, and translational regulation is essential for immune cells to promptly respond to stimuli and adapt to the microenvironment. N6-methyladenosine (m6A) methylation, which is t
Externí odkaz:
https://doaj.org/article/8a892380a14f4f9d9338c0b00fec6589
Publikováno v:
Advanced Science, Vol 10, Iss 35, Pp n/a-n/a (2023)
Abstract T helper type 9 (Th9) cells play important roles in immune responses by producing interleukin‐9 (IL‐9). Several transcription factors are responsible for Th9 cell differentiation; however, transcriptional regulation of Th9 cells is not f
Externí odkaz:
https://doaj.org/article/86f34fc2e3934eb6b5e1906acd966aa0
Autor:
Yimeng Gao, Joshua T. Zimmer, Radovan Vasic, Chengyang Liu, Rana Gbyli, Shu-Jian Zheng, Amisha Patel, Wei Liu, Zhihong Qi, Yaping Li, Raman Nelakanti, Yuanbin Song, Giulia Biancon, Andrew Z. Xiao, Sarah Slavoff, Richard G. Kibbey, Richard A. Flavell, Matthew D. Simon, Toma Tebaldi, Hua-Bing Li, Stephanie Halene
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113163- (2023)
Summary: N6-methyladenosine (m6A) RNA modification controls numerous cellular processes. To what extent these post-transcriptional regulatory mechanisms play a role in hematopoiesis has not been fully elucidated. We here show that the m6A demethylase
Externí odkaz:
https://doaj.org/article/18f048077b4b40258f667dc818d9c471
Autor:
Baiwen Chen, Jiajia Hu, Xianting Hu, Huifang Chen, Rujuan Bao, Yatao Zhou, Youqiong Ye, Meixiao Zhan, Wei Cai, Huabin Li, Hua-Bing Li
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Several mechanisms have been associated with transcriptional and post-transcriptional regulation of PD-L1 in cancer. Here the authors show that a RNA binding protein, DENR, positively regulates the translation of JAK2 and induces PD-L1 expression in
Externí odkaz:
https://doaj.org/article/09398a960963475ca57d3b0ed094f10f
Autor:
Hao Song, Jiaxi Song, Ming Cheng, Meijuan Zheng, Tian Wang, Sha Tian, Richard A. Flavell, Shu Zhu, Hua-Bing Li, Chen Ding, Haiming Wei, Rui Sun, Hui Peng, Zhigang Tian
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Post transcriptional modifications to RNA may be important in the function of NK cells but this is not fully known. Here the authors show that m6A-methyltransferase METTL3 deletion in NK cells leads to reduced function and protection against tumour c
Externí odkaz:
https://doaj.org/article/7c8a5352b1e0420daf32014d1ad232bd
Autor:
Qianwen Hu, Tingting Xu, Min Zhang, Heng Zhang, Yongbo Liu, Hua-bing Li, Chiqi Chen, Junke Zheng, Zhen Zhang, Fubin Li, Nan Shen, Wenqian Zhang, Ari Melnick, Chuanxin Huang
Publikováno v:
Cell Reports, Vol 40, Iss 1, Pp 111035- (2022)
Summary: During the early phase of primary humoral responses, activated B cells can differentiate into different types of effector cells, dependent on B cell receptor affinity for antigen. However, the pivotal transcription factors governing these pr
Externí odkaz:
https://doaj.org/article/80a4f479a0d644a3adb3de830be01f41
Autor:
Huifang Chen, Jiameng Yao, Rujuan Bao, Yu Dong, Ting Zhang, Yanhua Du, Gaoyang Wang, Duan Ni, Zhenzhen Xun, Xiaoyin Niu, Youqiong Ye, Hua-Bing Li
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-21 (2021)
Abstract Background The four major RNA adenosine modifications, i.e., m6A, m1A, alternative polyadenylation, and adenosine-to-inosine RNA editing, are mediated mostly by the “writer” enzymes and constitute critical mechanisms of epigenetic regula
Externí odkaz:
https://doaj.org/article/b3d0ca45a3fa4330843d44dc2dd36ef2
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
RNA modification represents one of the most ubiquitous mechanisms of epigenetic regulation and plays an essential role in modulating cell proliferation, differentiation, fate determination, and other biological activities. At present, over 170 types
Externí odkaz:
https://doaj.org/article/37e50a187a6b47d3bd6ee522bf73bf07
Autor:
Xiaoyan Yu, Yimin Lao, Xiao-Lu Teng, Song Li, Yan Zhou, Feixiang Wang, Xinwei Guo, Siyu Deng, Yuzhou Chang, Xuefeng Wu, Zhiduo Liu, Lei Chen, Li-Ming Lu, Jinke Cheng, Bin Li, Bing Su, Jin Jiang, Hua-Bing Li, Chuanxin Huang, Jing Yi, Qiang Zou
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Regulatory T cells are crucial for the establishment and maintenance of peripheral immune tolerance, yet the mechanisms regulating their stability and function remain to be fully elucidated. Here the authors show SENP3 maintains Treg cell stability a
Externí odkaz:
https://doaj.org/article/99392c4923a841bda11bc7886d22d63c
Publikováno v:
Open Biology, Vol 6, Iss 4 (2016)
The identification of m6A demethylases and high-throughput sequencing analysis of methylated transcriptome corroborated m6A RNA epigenetic modification as a dynamic regulation process, and reignited its investigation in the past few years. Many basic
Externí odkaz:
https://doaj.org/article/3f4387e866d045599f48ec62d0ea72e9