Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Hua-Tang Chen"'
Autor:
Sita D. Gupta, Ryan S. Mehan, Terese R. Tansey, Hua-Tang Chen, Gertrud Goping, Israel Goldberg, Ishaiahu Shechter
Publikováno v:
Journal of Lipid Research, Vol 40, Iss 9, Pp 1572-1584 (1999)
Farnesyl diphosphate synthase (FPPS: EC2.5.1.10), a key enzyme in isoprenoid metabolic pathways, catalyzes the synthesis of farnesyl diphosphate (FPP) an intermediate in the biosynthesis of both sterol and non-sterol isoprenoid end products. The loca
Externí odkaz:
https://doaj.org/article/39f6f95cc22d4c82ac9b3aa84d502448
Autor:
Masahiro Onozawa, Ji-Eun Lee, Paula Gutierrez-Martinez, Peter D. Aplan, Amanda Day, Aysegul V. Ergen, Kai Ge, Nadia Finkel, Elsa Callen, Margarida A. Santos, Hua Tang Chen, Susan O. Sharrow, Amy Malhowski, Keisuke Ito, Scott A. Armstrong, Andres Canela, Robert B. Faryabi, André Nussenzweig, Aniruddha J. Deshpande, Derrick J. Rossi, Nancy Wong
Publikováno v:
Nature. 514:107-111
Self-renewal is the hallmark feature both of normal stem cells and cancer stem cells. Since the regenerative capacity of normal haematopoietic stem cells is limited by the accumulation of reactive oxygen species and DNA double-strand breaks, we specu
Autor:
Jeremy A. Daniel, Oscar Fernandez-Capetillo, Anthony T. Tubbs, Ji-Eun Lee, Linda M. Starnes, Michael J. Kruhlak, Federica Polato, Frederick W. Alt, Hua Tang Chen, Kai Ge, Elsa Callen, Barry P. Sleckman, Michel C. Nussenzweig, Robert B. Faryabi, Margarida A. Santos, Maria Nieto-Soler, Duane R. Wesemann, André Nussenzweig, Michela Di Virgilio, Nancy Wong
Publikováno v:
Cell. 153:1266-1280
SummaryThe DNA damage response (DDR) protein 53BP1 protects DNA ends from excessive resection in G1, and thereby favors repair by nonhomologous end-joining (NHEJ) as opposed to homologous recombination (HR). During S phase, BRCA1 antagonizes 53BP1 to
Autor:
Avinash Bhandoola, Matilde Murga, Xi Wang, Anthony T. Tubbs, Aysegul V. Ergen, Vanesa Lafarga, Oscar Fernandez-Capetillo, Hua-Tang Chen, Kurt Gordon Pike, Elaine Cadogan, Scott A. Armstrong, Barlaam Bernard Christophe, Isabel Morgado-Palacin, André Nussenzweig, Rhonda Anderson, Marta Elena Anton, Amanda Day, Andrew J. Pierce, Chad Hubbard
Publikováno v:
Science Signaling. 9
Among the various subtypes of acute myeloid leukemia (AML), those with chromosomal rearrangements of the MLL oncogene (AML-MLL) have a poor prognosis. AML-MLL tumor cells are resistant to current genotoxic therapies because of an attenuated response
Autor:
Samuel F. Bunting, Nancy Wong, Michael D. Story, André Nussenzweig, Eric J. Gapud, Elsa Callen, Junke Zheng, Hirohiko Yajima, Barry P. Sleckman, Shichuan Zhang, Yu Fen Lin, David J. Chen, Hua Tang Chen, Mengxia Li, Hoang Dinh Huynh, Benjamin P C Chen, Cheng Cheng Zhang, Kyung Jone Lee
Publikováno v:
The Journal of Cell Biology
Phosphorylation of DNA-PKcs is essential for activation of DNA damage repair and for the maintenance of tissue stem cell populations.
The nonhomologous end-joining (NHEJ) pathway is essential for radioresistance and lymphocyte-specific V(D)J (va
The nonhomologous end-joining (NHEJ) pathway is essential for radioresistance and lymphocyte-specific V(D)J (va
Autor:
André Nussenzweig, Hua Tang Chen, Margarida A. Santos, Nancy Wong, Isaac A. Klein, Junjie Chen, Juan L R Barbancho, Michel C. Nussenzweig, Andrés J. López-Contreras, Oscar Fernandez-Capetillo, Michael S.Y. Huen, Mila Jankovic
Publikováno v:
The Journal of Experimental Medicine
The Journal of Cell Biology
The Journal of Cell Biology
53BP1 is a well-known mediator of the cellular response to DNA damage. Two alternative mechanisms have been proposed to explain 53BP1's interaction with DNA double-strand breaks (DSBs), one by binding to methylated histones and the other via an RNF8
53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks
Autor:
Samuel F. Bunting, Xiaoling Xu, Federica Polato, Niklas Feldhahn, Nancy Wong, Oscar Fernandez-Capetillo, André Nussenzweig, Anne Bothmer, Liu Cao, Chu-Xia Deng, Amanda Gunn, Hua Tang Chen, Michel C. Nussenzweig, Jeremy M. Stark, Elsa Callen, Toren Finkel
Publikováno v:
Cell
SummaryDefective DNA repair by homologous recombination (HR) is thought to be a major contributor to tumorigenesis in individuals carrying Brca1 mutations. Here, we show that DNA breaks in Brca1-deficient cells are aberrantly joined into complex chro
Autor:
Michela Di Virgilio, Simone Difilippantonio, Frederick W. Alt, Hua-Tang Chen, André Nussenzweig, Michel C. Nussenzweig, Gordon F. Heidkamp, Mila Jankovic, Nancy Wong, Elsa Callen, Shan Zha
Publikováno v:
Molecular Cell. 34:285-297
The DNA double-strand break (DSB) repair protein DNA-PKcs and the signal transducer ATM are both activated by DNA breaks and phosphorylate similar substrates in vitro, yet appear to have distinct functions in vivo. Here, we show that ATM and DNA-PKcs
Publikováno v:
Aging
NaCl induces DNA breaks, thus leading to cellular senescence. Here we showed that Ku86 deficiency accelerated the high NaCl-induced cellular senescence. We find that 1) high NaCl induces rapid cellular senescence in Ku86 deficient(xrs5) cells, 2) Ku8
Autor:
Simone Difilippantonio, Hua Tang Chen, Michel C. Nussenzweig, Elsa Callen, Anne E. Corcoran, Daniel J. Bolland, Bernardo Reina-San-Martin, Davide F. Robbiani, Anne Bothmer, André Nussenzweig, Yair Dorsett
Publikováno v:
Cell. 135(6):1028-1038
SummaryChromosomal translocation requires formation of paired double-strand DNA breaks (DSBs) on heterologous chromosomes. One of the most well characterized oncogenic translocations juxtaposes c-myc and the immunoglobulin heavy-chain locus (IgH) and