Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Hua-Qun Chen"'
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-13 (2024)
Abstract Tetrandrine (Tet), a well-known drug of calcium channel blocker, has been broadly applied for anti-inflammatory and anti-fibrogenetic therapy. However, due to the functional diversity of ubiquitous calcium channels, potential side-effects ma
Externí odkaz:
https://doaj.org/article/ca56769da1064f8bb53042f57f50d873
Autor:
Wen Yuan, Cong-Cong Cui, Jing Li, Yan-Hua Xu, Chun-E Fan, Yu-Chen Chen, Hong-Wei Fan, Bing-Xue Hu, Mei-Yun Shi, Zhi-Yuan Sun, Pei Wang, Teng-Xiang Ma, Zhao Zhang, Min-Sheng Zhu, Hua-Qun Chen
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105446- (2022)
Summary: Transmembrane protein 16A (TMEM16A) localizes at plasma membrane and controls chloride influx in various type of cells. We here showed an intracellular localization pattern of TMEM16A molecules. In myoblasts, TMEM16A was primarily localized
Externí odkaz:
https://doaj.org/article/0e8e37a69ab44c14aba798409481ef61
Autor:
Xin Chen, Tian-Tian Qiu, Ye Wang, Li-Yang Xu, Jie Sun, Zhi-Hui Jiang, Wei Zhao, Tao Tao, Yu-Wei Zhou, Li-Sha Wei, Ye-Qiong Li, Yan-Yan Zheng, Guo-Hua Zhou, Hua-Qun Chen, Jian Zhang, Xiao-Bo Feng, Fang-Yu Wang, Ning Li, Xue-Na Zhang, Jun Jiang, Min-Sheng Zhu
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 14 (2022)
Intractable functional constipation (IFC) is the most severe form of constipation, but its etiology has long been unknown. We hypothesized that IFC is caused by refractory infection by a pathogenic bacterium. Here, we isolated from patients with IFC
Externí odkaz:
https://doaj.org/article/f66f0af9a68a42ee836c5f2d73db7a57
Autor:
Yu-Wei Zhou, Jie Sun, Ye Wang, Cai-Ping Chen, Tao Tao, Ming Ma, Xin Chen, Xue-Na Zhang, Li-Yuan Yang, Zhong-Liang Zhang, Ye-Qiong Li, Zhi-Hui Jiang, Tian-Tian Qiu, Han Wang, Yang Pan, Jian Zhang, Hua-Qun Chen, Pei Wang, Min-Sheng Zhu
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Both chronic obstructive pulmonary disease (COPD) and asthma are severe respiratory diseases. Bitter receptor–mediated bronchodilation is a potential therapy for asthma, but the mechanism underlying the agonistic relaxation of airway smooth muscle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f884b97fb4bfad5d7d6f709bf71daa09
https://doi.org/10.1073/pnas.2121513119
https://doi.org/10.1073/pnas.2121513119
Autor:
Zhiyuan Sun, Wen Yuan, Shuai Li, Hua-Qun Chen, Qianqian Zhang, Min-Sheng Zhu, Li Liu, Tengxiang Ma, Jing Li, Xiaobin Song, Weiwei Zeng
Publikováno v:
Acta Biochimica et Biophysica Sinica. 53:567-574
Leucocyte adhesion to the vascular endothelium is a critical event in the early inflammatory response to infection and injury. This process is primarily regulated by the expression of cell adhesion molecules (CAMs) in endothelial cells. It has been w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891b566d1789cf3fae7019a1e01e63e2
https://doi.org/10.1093/abbs/gmab019
https://doi.org/10.1093/abbs/gmab019
Autor:
Zhenji Gan, Xin Chen, Pei Wang, Xuena Zhang, Yuwei Zhou, Jie Sun, Min-Sheng Zhu, Yun-Qian Gao, Tao Tao, Lisha Wei, Wei Zhao, Wei Wang, Yan-Yan Zheng, Yeqiong Li, Juan Liang, Hua-Qun Chen
Publikováno v:
Journal of Biological Chemistry. 295:8656-8667
Mutations in the myotubularin 1 (MTM1) gene can cause the fatal disease X-linked centronuclear myopathy (XLCNM), but the underlying mechanism is incompletely understood. In this report, using an Mtm1−/y disease model, we found that expression of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cb6bdad7fda4a1504c22f0607ede1ef
https://doi.org/10.1074/jbc.ra119.010839
https://doi.org/10.1074/jbc.ra119.010839
Autor:
Pei Wang, Yun Xu, Min-Sheng Zhu, Cai-Ping Chen, Yiteng Zhang, Zhiyuan Sun, Xiaobin Song, Jie Sun, He Zhang, Zhao Zhang, Shuai Li, Wei Zhao, Hua-Qun Chen, Lirong Zheng, Congcong Cui, Xiang Cao, Cheng-Hai Zhang, Weiwei Zeng
Publikováno v:
FASEB J
The paracellular gap formed by endothelial cell (EC) contraction is fundamental for endothelium permeability, but the mechanism underlying EC contraction has yet to be determined. Here, we identified the zipper-interacting protein kinase (ZIPK) as th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d26866e8cc0ac0995956b034cb96cb9e
https://doi.org/10.1096/fj.201802052rrr
https://doi.org/10.1096/fj.201802052rrr
Autor:
Xin Chen, Tian-Tian Qiu, Ye Wang, Li-Yang Xu, Jie Sun, Zhi-Hui Jiang, Wei Zhao, Tao Tao, Yu-Wei Zhou, Li-Sha Wei, Ye-Qiong Li, Yan-Yan Zheng, Guo-Hua Zhou, Hua-Qun Chen, Jian Zhang, Xiao-Bo Feng, Fang-Yu Wang, Ning Li, Xue-Na Zhang, Jun Jiang, Min-Sheng Zhu
Publikováno v:
The Journal of clinical investigation. 132(14)
Intractable functional constipation (IFC) is the most severe form of constipation, but its etiology has long been unknown. We hypothesized that IFC is caused by refractory infection by a pathogenic bacterium. Here, we isolated from patients with IFC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a286a5f44eb8786f21d88ca772302e
https://pubmed.ncbi.nlm.nih.gov/35850193
https://pubmed.ncbi.nlm.nih.gov/35850193
Autor:
Yu-Wei Zhou, Jie Sun, Ye Wang, Cai-Ping Chen, Tao Tao, Ming Ma, Xin Chen, Xue-Na Zhang, Li-Yuan Yang, Zhong-Liang Zhang, Ye-Qiong Li, Zhi-Hui Jiang, Tian-Tian Qiu, Han Wang, Yang Pan, Jian Zhang, Hua-Qun Chen, Pei Wang, Min-Sheng Zhu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 6/28/2022, Vol. 119 Issue 26, p1-9, 27p
Autor:
Xia Gao, Tao Tao, Linqing Zhang, Guang-Jie Zhu, Dengbin Ma, Jie Sun, Chi Fan, Xin Chen, Wei Zhao, Jian Zuo, Fang Wang, Pei Wang, Hua-Qun Chen, Xiang Gao, Min-Sheng Zhu, Han Zhou, Guoqiang Wan, Wei-Qi He, Ye Wang, Xiaoyun Qian, Sihao Gong
Publikováno v:
PLoS Genetics, Vol 16, Iss 9, p e1009040 (2020)
PLoS Genetics
PLoS Genetics
Genetic hearing loss is a common health problem with no effective therapy currently available. DFNA15, caused by mutations of the transcription factor POU4F3, is one of the most common forms of autosomal dominant non-syndromic deafness. In this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaea0ebc529108de63bdb15e5b46f69d
https://doaj.org/article/f0246d9084034f89908c03ec0f0b17f6
https://doaj.org/article/f0246d9084034f89908c03ec0f0b17f6