Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Hua-Quan Miao"'
Autor:
Hua-Quan Miao, Jin-Ping Li Li, Fenghuang Zhan, Israel Vlodavsky, Veronica MacLeod, Eyal Zcharia, John D. Shaughnessy, Ralph D. Sanderson, Jeffrey R. Sawyer, Allison Theus, Yang Yang
Publikováno v:
Journal of Biological Chemistry. 282:13326-13333
When shed from the cell surface, the heparan sulfate proteoglycan syndecan-1 can facilitate the growth, angiogenesis, and metastasis of tumors. Here we report that tumor cell expression of heparanase, an enzyme known to be a potent promoter of tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28f0cc1c73d676233d668e5ade15d240
https://doi.org/10.1074/jbc.m611259200
https://doi.org/10.1074/jbc.m611259200
Autor:
Jeffrey L. Platt, Xiulong Xu, Gregory J. Brunn, Anthony W. Kim, Paolo Gattuso, Hua Quan Miao, Richard A. Prinz, Geetha Rao, Roderick M. Quiros
Publikováno v:
Journal of Biological Chemistry. 282:2363-2373
Heparan sulfate proteoglycans (HSPGs) function as a co-receptor for heparin-binding growth factors, such as fibroblast growth factors (FGFs) and heparin-bound epidermal growth factor (HB-EGF). The HS side chain of HSPGs can be cleaved by HPR1 (hepara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34a47e604af8ade50fd6713b693eb883
https://doi.org/10.1074/jbc.m604218200
https://doi.org/10.1074/jbc.m604218200
Publikováno v:
Current Medicinal Chemistry. 13:2101-2111
Heparanase is an endo-beta-D-glucuronidase that degrades heparan sulfate glycosaminoglycan side chains of the proteoglycans in extracellular matrix and basement membrane. Heparanase enzymatic activity is important in the promotion of tumor angiogenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ccbe81f0e81809d3b5c605d59736a69
https://doi.org/10.2174/092986706777935230
https://doi.org/10.2174/092986706777935230
Autor:
Haifan Zhang, Elizabeth Navarro, Zhenping Zhu, Dale L. Ludwig, Hua-Quan Miao, Dan Lu, Paul Balderes, Kun Hu, Xenia Jimenez
Publikováno v:
Biochemical and Biophysical Research Communications. 345:438-445
Compelling evidence suggest that vascular endothelial growth factor (VEGF) and its receptors, especially receptor 2 (VEGFR2, or kinase insert domain-containing receptor, KDR), play a critical role in angiogenesis under both physiological and patholog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba357be0d807330d6d12c5ccd6fc7122
https://doi.org/10.1016/j.bbrc.2006.04.119
https://doi.org/10.1016/j.bbrc.2006.04.119
Autor:
Larry Witte, Kris Persaud, Hua-Quan Miao, Xenia Jimenez, Laura Brennan, Dan Lu, Meilin Liu, Zhenping Zhu
Publikováno v:
Scopus-Elsevier
Vascular endothelial growth factors (VEGF) and their receptors (VEGFR) have been implicated to play important roles in tumor-associated angiogenesis and lymphangiogenesis, and hence in tumor growth and metastasis. We previously produced a number of f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04cd4e963735c781d5d0302bf8374463
https://doi.org/10.1158/1535-7163.mct-04-0261
https://doi.org/10.1158/1535-7163.mct-04-0261
Autor:
Persaud, Kris, Tille, Jean-Christophe, Meilin Liu, Zhenping Zhu, Xenia Jimenez, S. Pereira, Daniel, Hua-Quan Miao, Brennan, Laura A., Witte, Larry, Pepper, Michael S., Pytowski, Bronislaw
Publikováno v:
Journal of Cell Science; Sep2023, Vol. 136 Issue 17, p1-1, 1p
Publikováno v:
Biochemical and Biophysical Research Communications. 308:885-891
Heparanase is an endo-beta-D-glucuronidase involved in cleavage of heparan sulfate residues and hence participates in extracellular matrix degradation and remodeling. The heparanase cDNA encodes for a polypeptide of 543 amino acids that appears as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1520b91ab76d76e45eedd8d40848ca07
https://doi.org/10.1016/s0006-291x(03)01478-5
https://doi.org/10.1016/s0006-291x(03)01478-5
Autor:
Michael Elkin, Mark Pines, Israel Vlodavsky, Itzhak Hemo, Hua-Quan Miao, Arnon Nagler, Reuven Reich, Hong-Liang Dou, Elena Aingorn
Publikováno v:
The FASEB Journal. 14:2477-2485
We have previously demonstrated that halofuginone, a low molecular weight quinazolinone alkaloid, is a potent inhibitor of collagen alpha1(I) and matrix metalloproteinase 2 (MMP-2) gene expression. Halofuginone also effectively suppresses tumor progr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127336582b50674aff3e7bd6a03f77bc
https://doi.org/10.1096/fj.00-0292com
https://doi.org/10.1096/fj.00-0292com
Autor:
Ze'ev Gechtman, Michael Klagsbrun, Shay Soker, Diane R. Bielenberg, Hua-Quan Miao, Michael L. Gagnon, Seiji Takashima
Publikováno v:
Proceedings of the National Academy of Sciences. 97:2573-2578
Neuropilin-1 (NRP1) is a 130-kDa transmembrane receptor for semaphorins, mediators of neuronal guidance, and for vascular endothelial growth factor 165 (VEGF 165 ), an angiogenesis factor. A 2.2-kb truncated NRP1 cDNA was cloned that encodes a 644-aa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faf31fa1e04a5fbf2cfcb9ba02d94314
https://doi.org/10.1073/pnas.040337597
https://doi.org/10.1073/pnas.040337597
Autor:
Hua-Quan Miao, Michael Klagsbrun
Publikováno v:
Cancer and Metastasis Reviews. 19:29-37
Neuropilin is both a receptor for semaphorins, which are mediators of neuronal guidance, and for VEGF, an angiogenesis factor. While the function of neuropilin in the nervous system has been characterized, its role in angiogenesis is only beginning t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ac4efdfee374d603250fc6e08059bc0
https://doi.org/10.1023/a:1026579711033
https://doi.org/10.1023/a:1026579711033