Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Hua-Jun Wu"'
Autor:
Chunge Zhong, Wen-Jie Jiang, Yingjia Yao, Zexu Li, You Li, Shengnan Wang, Xiaofeng Wang, Wenjuan Zhu, Siqi Wu, Jing Wang, Shuangshuang Fan, Shixin Ma, Yeshu Liu, Han Zhang, Wenchang Zhao, Lu Zhao, Yi Feng, Zihan Li, Ruifang Guo, Li Yu, Fengyun Pei, Jun Hu, Xingzhi Feng, Zihuan Yang, Zhengjia Yang, Xueying Yang, Yue Hou, Danni Zhang, Dake Xu, Ren Sheng, Yihao Li, Lijun Liu, Hua-Jun Wu, Jun Huang, Teng Fei
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Resistance to chemotherapy has been a major hurdle that limits therapeutic benefits for many types of cancer. Here we systematically identify genetic drivers underlying chemoresistance by performing 30 genome-scale CRISPR knockout screens fo
Externí odkaz:
https://doaj.org/article/e05d9e0e44d3454b9b83a793d45bfd7a
Autor:
Gangjian Wang, Haojie Wang, Xin Ji, Tong Wang, Ye Zhang, Wenjie Jiang, Lin Meng, Hua-Jun Wu, Xiaofang Xing, Jiafu Ji
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
The role of the intratumoral microbiome in gastric cancer (GC) has not been comprehensively assessed. Here, we explored the relationship between the microbial community and GC prognosis and therapy efficacy. Several cancer-associated microbial charac
Externí odkaz:
https://doaj.org/article/a16842ba8af64b54a9c3e226d693e837
Autor:
Alexandro Landshammer, Adriano Bolondi, Helene Kretzmer, Christian Much, René Buschow, Alina Rose, Hua-Jun Wu, Sebastian D Mackowiak, Bjoern Braendl, Pay Giesselmann, Rosaria Tornisiello, Krishna Mohan Parsi, Jack Huey, Thorsten Mielke, David Meierhofer, René Maehr, Denes Hnisz, Franziska Michor, John L Rinn, Alexander Meissner
Publikováno v:
eLife, Vol 12 (2023)
Long non-coding RNAs (lncRNAs) have emerged as fundamental regulators in various biological processes, including embryonic development and cellular differentiation. Despite much progress over the past decade, the genome-wide annotation of lncRNAs rem
Externí odkaz:
https://doaj.org/article/3fce62d60c7b4d80ba98c9f07f7a3da0
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 12, p e1010753 (2022)
Identifying cell clusters is a critical step for single-cell transcriptomics study. Despite the numerous clustering tools developed recently, the rapid growth of scRNA-seq volumes prompts for a more (computationally) efficient clustering method. Here
Externí odkaz:
https://doaj.org/article/6aa1c8bea5bb49c19a13407bb52851bb
Autor:
Hua-Jun Wu, Alexandro Landshammer, Elena K. Stamenova, Adriano Bolondi, Helene Kretzmer, Alexander Meissner, Franziska Michor
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The phenotypic consequence of 3D genome boundary disruption on developmental processes remains insufficiently understood. Here, the authors show that perturbation of a SOX17 boundary in human pluripotent stem cells interferes with proper differentiat
Externí odkaz:
https://doaj.org/article/74703824e0ed457c97e98fe375a89f8b
Autor:
Ben Wang, Tian Lan, Han Xiao, Zhong-Huo Chen, Chao Wei, Lei-Feng Chen, Jia-Fu Guan, Rong-Fa Yuan, Xin Yu, Zhi-Gang Hu, Hua-Jun Wu, Zhi Dai, Kai Wang
Publikováno v:
Cancer Cell International, Vol 21, Iss 1, Pp 1-17 (2021)
Abstract Background The HSP70 family of heat shock protein plays a critical role in protein synthesis and transport to maintain protein homeostasis. Several studies have indicated that HSP70s are related to the development and occurrence of various c
Externí odkaz:
https://doaj.org/article/293dfec88bbe44e58d25483524848610
Autor:
Yu-Ling Cao, Li -Zhu, Hong Zhang, Jun-Hua Meng, Hua-Jun Wu, Xiong Wang, Jin-Hu Wu, Ji-Li Zou, Mao-Sheng Fang, Jing An, Yong-Gang Chen
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background: The dopamine D2 receptor (DRD2) plays an important role in the increased prolactin (PRL) levels associated with the pathogenesis of antipsychotic drugs (ADs). Elevated prolactin levels can affect people’s quality of life. Maiya alkaloid
Externí odkaz:
https://doaj.org/article/4b7cb7222445437a959e12baf4aa1880
Autor:
Chao Wei, Ben Wang, Zhong-Huo Chen, Han Xiao, Lei Tang, Jia-Fu Guan, Rong-Fa Yuan, Xin Yu, Zhi-Gang Hu, Hua-Jun Wu, Zhi Dai, Kai Wang
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
RRP12 (ribosomal RNA processing 12 homolog) is a nucleolar protein involved in the maturation and transport of eukaryotic ribosomal subunits and is a type of RNA binding protein. In recent years, considerable research has indicated that RRP12 is asso
Externí odkaz:
https://doaj.org/article/9fc8c1179a924c47b552d9062f232e51
Autor:
Hyun Jung Jun, Vicky A. Appleman, Hua-Jun Wu, Christopher M. Rose, Javier J. Pineda, Alan T. Yeo, Bethany Delcuze, Charlotte Lee, Aron Gyuris, Haihao Zhu, Steve Woolfenden, Agnieszka Bronisz, Ichiro Nakano, Ennio A. Chiocca, Roderick T. Bronson, Keith L. Ligon, Jann N. Sarkaria, Steve P. Gygi, Franziska Michor, Timothy J. Mitchison, Al Charest
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Amplification of PDGFRα is a common alteration in glioblastoma. In this study, the authors develop a genetically engineered mouse model of GBM based on autocrine, chronic stimulation of overexpressed PDGFR and discover Stathmin1 as an important PDGF
Externí odkaz:
https://doaj.org/article/e36e588f60e24fb6aa72e07d8947fc7d
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 11, p e1008452 (2020)
Deconvolution of heterogeneous bulk tumor samples into distinct cellular populations is an important yet challenging problem, particularly when only partial references are available. A common approach to dealing with this problem is to deconvolve the
Externí odkaz:
https://doaj.org/article/704af6b68aa44856ace7f974c1e43838