Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Hua-Bei Guo"'
Autor:
Tamas Nagy, Hua-Bei Guo, Bing Zhang, Phillip Buckhaults, Kelley W. Moremen, Alison V. Nairn, Michael Pierce
To study the regulation of colorectal adenocarcinoma progression by O-GlcNAc, we have focused on the O-GlcNAc-mediated epigenetic regulation of human colon cancer stem cells (CCSC). Xenograft tumors from colon tumor cells with O-linked N-acetylglucos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf4cc29b5ea5eb7d639d421b79c74df
https://europepmc.org/articles/PMC5354504/
https://europepmc.org/articles/PMC5354504/
Publikováno v:
Journal of Biological Chemistry. 289:31534-31549
Deletion of GnT-V (MGAT5), which synthesizes N-glycans with β(1,6)-branched glycans, reduced the compartment of cancer stem cells (CSC) in the her-2 mouse model of breast cancer, leading to delay of tumor onset. Because GnT-V levels are also commonl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca8ebb0ce5c9f88317e4445e075d08b
https://doi.org/10.1074/jbc.m114.602680
https://doi.org/10.1074/jbc.m114.602680
Publikováno v:
Journal of Biological Chemistry. 284:34986-34997
The effects of altering N-cadherin N-glycosylation on several cadherin-mediated cellular behaviors were investigated using small interfering RNA and site-directed mutagenesis. In HT1080 fibrosarcoma cells, small interfering RNA-directed knockdown of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8acb933d7483d153cac3b6296f60d15d
https://doi.org/10.1074/jbc.m109.060806
https://doi.org/10.1074/jbc.m109.060806
Publikováno v:
Journal of Biological Chemistry. 282:22150-22162
Changes in the expression of glycosyltransferases that branch N-linked glycans can alter the function of several types of cell surface receptors and a glucose transporter. To study in detail the mechanisms by which aberrant N-glycosylation caused by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a525412357f8305fa5a9749497b33e2
https://doi.org/10.1074/jbc.m611518200
https://doi.org/10.1074/jbc.m611518200
Autor:
Hua-Bei Guo, Karen L. Abbott
Changes in glycosylation have been implicated in various human diseases, including cancer. Research over the past few decades has produced significant findings that illustrate the importance of cancer-specific alterations in glycosylation in the regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0cb5e8e49d15f86e6dd35fa0fbaa42c
https://doi.org/10.1016/bs.acr.2014.11.006
https://doi.org/10.1016/bs.acr.2014.11.006
Autor:
Karolyn Troupe, Michael Pierce, Intaek Lee, Maria Kamar, Jin-Kyu Lee, Hua-Bei Guo, Karen L. Abbott, Gerardo Alvarez-Manilla
Publikováno v:
Journal of Neurochemistry. 97:947-956
N-acetylglucosaminyltransferase VB (GnT-VB, -IX) is a newly discovered glycosyltransferase expressed exclusively in high levels in neuronal tissue during early development. Its homolog, GnT-V, is expressed in many tissues and modulates cell-cell and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9c1c1811857ce6bc0a7096523e4c6be
https://doi.org/10.1111/j.1471-4159.2006.03785.x
https://doi.org/10.1111/j.1471-4159.2006.03785.x
Publikováno v:
Journal of Biological Chemistry. 280:8332-8342
An N-linked glycan often increased during oncogenic transformation contains beta(1,6)-linked GlcNAc, synthesized by the N-acetylglucosaminyltransferase V (GnT-V). The progression of polyoma middle T-antigen oncoprotein-induced mammary carcinomas in G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5221018d592c6aec8fd646dfda474663
https://doi.org/10.1074/jbc.m413532200
https://doi.org/10.1074/jbc.m413532200
Publikováno v:
Journal of Biological Chemistry. 279:53007-53014
Vacuolar H(+)-ATPase functions as a vacuolar proton pump and is responsible for acidification of intracellular compartments such as the endoplasmic reticulum, Golgi, lysosomes, and endosomes. Previous reports have demonstrated that a 16-kDa subunit (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fdfda6c66bb170dcec27dc451cdacc2
https://doi.org/10.1074/jbc.m405717200
https://doi.org/10.1074/jbc.m405717200
Publikováno v:
Molecular and Cellular Biochemistry. 260:137-146
The relations between the structure of cell surface N-glycans to cell behaviors were studied in H7721 human hepatocarcinoma cell line, which predominantly expressed complex-type N-glycans on the surface. 1-Deoxymannojirimycin (DMJ) and swaisonine (SW
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3fe65baf25381ce79352b201a98888
https://doi.org/10.1023/b:mcbi.0000026065.84798.62
https://doi.org/10.1023/b:mcbi.0000026065.84798.62
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 127:231-236
Purpose: To study the relation of N-glycan structure on cell surface glycoproteins to the metastatic phenotypes. Methods: Two human hepatocarcinoma 7721 cell lines transfected with sense or antisense cDNA of GnT-V, named GnT-V/7721 and GnT-V-AS/7721,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f433d6aa87c9c33a31519b4de737fd28
https://doi.org/10.1007/s004320000186
https://doi.org/10.1007/s004320000186