Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Hua Chang Chen"'
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 1, p e1011786 (2024)
Adapter trimming is an essential step for analyzing small RNA sequencing data, where reads are generally longer than target RNAs ranging from 18 to 30 bp. Most adapter trimming tools require adapter information as input. However, adapter information
Externí odkaz:
https://doaj.org/article/03bbb53df7504b1bb6905fb12c260480
Autor:
Li-Ching Huang, Lindsey K. Stolze, Hua-Chang Chen, Alexander Gelbard, Yu Shyr, Qi Liu, Quanhu Sheng
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 4044-4055 (2023)
Single-cell sequencing have been widely used to characterize cellular heterogeneity. Sample multiplexing where multiple samples are pooled together for single-cell experiments, attracts wide attention due to its benefits of increasing capacity, reduc
Externí odkaz:
https://doaj.org/article/ff683179d5d44a2a94fa817ffb63d090
Autor:
Sony Tuteja, Zhihong Yu, Otis Wilson, Hua‐Chang Chen, Frank Wendt, Cecilia P. Chung, Shailja C. Shah, Christine M. Hunt, Ayako Suzuki, Catherine Chanfreau, Bryan R. Gorman, Jacob Joseph, Shiuh‐Wen Luoh, Valerio Napolioni, Cassianne Robinson‐Cohen, Ran Tao, Jin Zhou, Kyong‐Mi Chang, Adriana M. Hung, the VA Million Veteran Program COVID‐19 Science Initiative
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 8, Pp 1880-1886 (2022)
Abstract Remdesivir is the first US Food and Drug Administration (FDA)‐approved drug for the treatment of coronavirus disease 2019 (COVID‐19). We conducted a retrospective pharmacogenetic study to examine remdesivir‐associated liver enzyme elev
Externí odkaz:
https://doaj.org/article/7bae9f9cc503422b9e1b5d18da448c25
Autor:
Liu, Jing Wang, Hua-Chang Chen, Quanhu Sheng, T. Renee Dawson, Robert J. Coffey, James G. Patton, Alissa M. Weaver, Yu Shyr
Publikováno v:
Cancers; Volume 15; Issue 13; Pages: 3446
Motivation: Extracellular vesicles (EVs) are produced and released by most cells and are now recognized to play a role in intercellular communication through the delivery of molecular cargo, including proteins, lipids, and RNA. Small RNA sequencing (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::0df3088e36599bcd117605929f71c233
Publikováno v:
Hum Mutat
Prioritizing causal variants is one major challenge for the clinical application of sequencing data. Prompted by the observation that 74.3% of missense pathogenic variants locate in protein domains, we developed an approach named domain damage index
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a97913b9a492d53b59864a0b2893b2
https://doi.org/10.1002/humu.24269
https://doi.org/10.1002/humu.24269
Autor:
Hua-Chang Chen, Hong-Xuan Lin, Wang-Wei Ye, Jun-Xiang Shan, Shanjin Huang, Zi-Qi Lu, Min Diao, Nai-Qian Dong, Tao Guo, Ke Chen
Publikováno v:
Plant Physiology. 182:1346-1358
Phosphoinositides (PIs) as regulatory membrane lipids play essential roles in multiple cellular processes. Although the exact molecular targets of PI-dependent modulation remain largely elusive, the effects of disturbed PI metabolism could be employe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91652a255d5af4256cc1bb660838903c
https://doi.org/10.1104/pp.19.01131
https://doi.org/10.1104/pp.19.01131
Autor:
Elvis A, Akwo, Hua-Chang, Chen, Ge, Liu, Jefferson L, Triozzi, Ran, Tao, Zhihong, Yu, Cecilia P, Chung, Ayush, Giri, T Alp, Ikizler, C Michael, Stein, Edward D, Siew, QiPing, Feng, Cassianne, Robinson-Cohen, Adriana M, Hung
Publikováno v:
Kidney international reports. 7(8)
Common variants in theWe tested associations betweenAmong 648,593 veterans, mean (SD) age was 62 (14) years; 9% were female, 19% Black, and 8% Hispanic. In White patients, the rs4293393Robust associations were observed between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::32a9d5b77ea5b56df3c178882c0397d6
https://pubmed.ncbi.nlm.nih.gov/35967117
https://pubmed.ncbi.nlm.nih.gov/35967117
Autor:
Laster, Marciana L., Rowan, Bryce, Hua-Chang Chen, Schwantes-An, Tae-Hwi, Xin Sheng, Friedman, Peter A., Ikizler, T. Alp, Sinshiemer, Janet S., Ix, Joachim H., Susztak, Katalin, de Boer, Ian H., Kestenbaum, Bryan, Hung, Adriana, Moe, Sharon M., Perwad, Farzana, Robinson-Cohen, Cassianne
Publikováno v:
Journal of Clinical Endocrinology & Metabolism; Sep2022, Vol. 107 Issue 9, pe3866-e3876, 11p
Autor:
Xuan Zhang, Hua-Chang Chen, Fengwei Li, Lun Yao, D. Lei, Tao Sun, Xiangdong Liu, Bo Fang, Chen J, Wei Zhang, Dawei Wu, Lixian Ma, K. Liu, Q. Huang, Shuai Li
Directed evolution (DE) inspired by natural evolution (NE) has been achieving tremendous successes in protein/enzyme engineering. However, the conventional ‘one-protein-for-one-task’ DE cannot match the ‘multi-proteins-for-multi-tasks’ NE in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23c4d8853b51065db8745deef00125bd
https://doi.org/10.1101/2020.12.25.424376
https://doi.org/10.1101/2020.12.25.424376
Autor:
Cindy Lowe, Darren R. Tyson, Portia L. Thomas, Yun Kai Zhang, Shamilene Sivagnanam, Sarah M. Groves, Qi Liu, Kelli L. Boyd, Wade T. Iams, Hua Chang Chen, Jia Li, Lisa M. Coussens, Vito Quaranta, Yingjun Yan, Prasad R. Kopparapu, Paula Gonzalez-Ericsson, Courtney Betts, Christine M. Lovly, Heidi Chen
Publikováno v:
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 16(7)
The programmed death-ligand 1 (PD-L1) immune checkpoint inhibitors, atezolizumab and durvalumab, have received regulatory approval for the first-line treatment of patients with extensive-stage SCLC. Nevertheless, when used in combination with platinu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30079fabb647fe34d373cbd9c31104cb
https://pubmed.ncbi.nlm.nih.gov/34154789
https://pubmed.ncbi.nlm.nih.gov/34154789