Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Hua A. Jenny Lu"'
Autor:
Kenji Tsuji, Teodor G. Păunescu, Hani Suleiman, Dongping Xie, Fahmy A. Mamuya, Jeffrey H. Miner, Hua A. Jenny Lu
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Helium ion scanning microscopy (HIM) is a novel technology that directly visualizes the cell surface ultrastructure without surface coating. Despite its very high resolution, it has not been applied extensively to study biological or patholo
Externí odkaz:
https://doaj.org/article/7e560862969a41ccb11700805fd53622
Autor:
Yue Xu, Xiaoqiang Geng, Zhiwei Qiu, Guangying Shao, Shun Zhang, Baoxue Yang, Hong Zhou, Yingli Jia, Jinzhao He, Liang Wang, William Jin, Min Li, Jia Meng, Xiaowei Li, Hua A. Jenny Lu, Shuyuan Wang, Huihui Huang
Publikováno v:
J Am Soc Nephrol
Background Autosomal dominant polycystic kidney disease (ADPKD) is characterized by numerous cysts originating from renal tubules and is associated with significant tubular epithelial cell proliferation. Focal adhesion kinase (FAK) promotes tumor gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::249a44f6c5cce887e3cb0d31f5c0564a
https://europepmc.org/articles/PMC8729842/
https://europepmc.org/articles/PMC8729842/
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131719 (2015)
In renal collecting duct (CD) principal cells (PCs), vasopressin (VP) acts through its receptor, V2R, to increase intracellular cAMP leading to phosphorylation and apical membrane accumulation of the water channel aquaporin 2 (AQP2). The trafficking
Externí odkaz:
https://doaj.org/article/762737926adc46528aa63a0ec67e9a6f
Autor:
Ming Huang, Teodor G. Păunescu, Baoxue Yang, Kenji Tsuji, Dongping Xie, Hua A. Jenny Lu, Fahmy A. Mamuya, Onju Ham, Limin Su, Lei Lei
Publikováno v:
American Journal of Physiology-Renal Physiology. 314:F306-F316
Aquaporin-2 (AQP2) is a water channel protein expressed in principal cells (PCs) of the kidney collecting ducts (CDs) and plays a critical role in mediating water reabsorption and urine concentration. AQP2 undergoes both regulated trafficking mediate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6194b9c8e32fd5b72f04687895c67ab6
https://doi.org/10.1152/ajprenal.00391.2017
https://doi.org/10.1152/ajprenal.00391.2017
Autor:
James M. Daley, Kenji Tsuji, Jeffrey H. Miner, Hua A. Jenny Lu, Teodor G. Păunescu, Hani Suleiman, Diane E. Capen
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports
Scientific Reports
The glomerulus exercises its filtration barrier function by establishing a complex filtration apparatus consisting of podocyte foot processes, glomerular basement membrane and endothelial cells. Disruption of any component of the glomerular filtratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955f02c82d8faaa7b44fb7f9773a80f2
http://link.springer.com/article/10.1038/s41598-017-12064-5
http://link.springer.com/article/10.1038/s41598-017-12064-5
Autor:
Heyu Ji, Hua A. Jenny Lu, William Jin, Huihui Huang, Ming Huang, Junying Yuan, Teodor G. Păunescu, Diane E. Capen, Yin Xia
Publikováno v:
J Am Soc Nephrol
BACKGROUND: Gentamicin is a potent aminoglycoside antibiotic that targets gram-negative bacteria, but nephrotoxicity limits its clinical application. The cause of gentamicin-induced AKI has been attributed mainly to apoptosis of the proximal tubule c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220e53dd64768d8e1b409e4dfe8ac42b
https://pubmed.ncbi.nlm.nih.gov/32641397
https://pubmed.ncbi.nlm.nih.gov/32641397
Autor:
Diane E. Capen, Dongping Xie, Shuai Zhu, Teodor G. Păunescu, Ming Huang, Kenji Tsuji, Onju Ham, Huihui Huang, Baoxue Yang, Jinzhao He, Hua A. Jenny Lu, William Jin, Weining Lu
Publikováno v:
J Am Soc Nephrol
Background Necroptosis is a newly discovered cell death pathway that plays a critical role in AKI. The involvement of integrin-linked kinase (ILK) in necroptosis has not been studied. Methods We performed experiments in mice with an Ilk deletion in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::801545d59f8ad0fa2cfde0e76a10879d
https://pubmed.ncbi.nlm.nih.gov/31653783
https://pubmed.ncbi.nlm.nih.gov/31653783
Autor:
Kenji Tsuji, Lei Lei, Hui Hui Huang, Onju Ham, Hua A. Jenny Lu, Jason D. Roh, William Jin, Anthony Rosenzweig, Ming Huang
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
Scientific Reports
Scientific Reports
Cardiovascular disease constitutes the leading cause of mortality in patients with chronic kidney disease (CKD) and end-stage renal disease. Despite increasing recognition of a close interplay between kidney dysfunction and cardiovascular disease, te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6023bb1120c3168be2b79d79c754dca2
https://doi.org/10.1038/s41598-018-34216-x
https://doi.org/10.1038/s41598-018-34216-x
Autor:
Shrikant R. Mulay, Zhihua Zheng, Yu Huang, Hui-Yao Lan, Herbert Y. Lin, Hua A. Jenny Lu, Hans-Joachim Anders, Chenling Meng, Andong Qiu, Jinzhong Qin, Wenjing Liu, Gordon J. Freeman, Binbin Chen, Yang Wang, Huihui Huang, Xiao-Ru Huang, Yin Xia, Baoxue Yang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(7)
Tubular cell necrosis is a key histological feature of acute kidney injury (AKI). Necroptosis is a type of programed necrosis, which is executed by mixed lineage kinase domain-like protein (MLKL) upon its binding to the plasma membrane. Emerging evid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee76205fa8c58e6f7f99b9f16db21b93
https://pubmed.ncbi.nlm.nih.gov/29382757
https://pubmed.ncbi.nlm.nih.gov/29382757
Autor:
Teodor G. Păunescu, Kenji Tsuji, Ralph Weissleder, Dongping Xie, Fahmy A. Mamuya, Lei Lei, Diane E. Capen, Hua A. Jenny Lu, Baoxue Yang, Ming Huang
Publikováno v:
American journal of physiology. Renal physiology. 313(4)
The renal collecting duct (CD) contains two major cell types, intercalated (ICs) and principal cells (PCs). A previous report showed that deletion of β1-integrin in the entire renal CD causes defective CD morphogenesis resulting in kidney dysfunctio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e66f4632d910edbf375e62a6dfe6472
https://pubmed.ncbi.nlm.nih.gov/28701310
https://pubmed.ncbi.nlm.nih.gov/28701310