Polymyxin B-inspired non-hemolytic tyrocidine A analogues with significantly enhanced activity against gram-negative bacteria: How cationicity impacts cell specificity and antibacterial mechanism

Autor: Zhu, Jibao, Hu, Chengfei, Zeng, Zizhen, Deng, Xiaoyu, Zeng, Lingbing, Xie, Saisai, Fang, Yuanying, Jin, Yi, Alezra, Valérie, Wan, Yang

Publikováno v: In European Journal of Medicinal Chemistry 5 October 2021 221

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Development of Therapeutic Gramicidin S Analogues Bearing Plastic β,γ‐Diamino Acids.

Autor: Guan, Qinkun, Chen, Kaisen, Chen, Qiang, Hu, Jianguo, Cheng, Keguang, Hu, Chengfei, Zhu, Jibao, Jin, Yi, Miclet, Emeric, Alezra, Valérie, Wan, Yang

Publikováno v: ChemMedChem; 6/17/2020, Vol. 15 Issue 12, p1089-1100, 12p

Gramicidin-S-Inspired Cyclopeptidomimetics as Potent Membrane-Active Bactericidal Agents with Therapeutic Potential.

Autor: Hu C; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, 1688 Meiling Avenue, WanLi, Nanchang 330004, China., Wen Q; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, 1688 Meiling Avenue, WanLi, Nanchang 330004, China., Huang S; Jiangxi Maternal and Child Hospital, 318 Bayi Avenue, Nanchang, 330006, China., Xie S; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, 1688 Meiling Avenue, WanLi, Nanchang 330004, China., Fang Y; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, 1688 Meiling Avenue, WanLi, Nanchang 330004, China., Jin Y; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, 1688 Meiling Avenue, WanLi, Nanchang 330004, China., Campagne R; Laboratoire de Méthodologie, Synthèse et Molécules Thérapeutiques (ICMMO), Université Paris-Sud, UMR 8182, CNRS, Université Paris-Saclay, Bât 410, Facultédes Sciences d'Orsay, Orsay, 291405, France., Alezra V; Laboratoire de Méthodologie, Synthèse et Molécules Thérapeutiques (ICMMO), Université Paris-Sud, UMR 8182, CNRS, Université Paris-Saclay, Bât 410, Facultédes Sciences d'Orsay, Orsay, 291405, France., Miclet E; Laboratoire des Biomolécules, Sorbonne Université, PSL University, CNRS, 4 Place Jussieu, Paris, 75005, France., Zhu J; Institute of Traditional Chinese Medicine, Jiangxi University of Traditional Chinese Medicine, 1688 Meiling Avenue, WanLi, Nanchang 330004, China., Wan Y; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, 1688 Meiling Avenue, WanLi, Nanchang 330004, China.; Laboratoire de Méthodologie, Synthèse et Molécules Thérapeutiques (ICMMO), Université Paris-Sud, UMR 8182, CNRS, Université Paris-Saclay, Bât 410, Facultédes Sciences d'Orsay, Orsay, 291405, France.

Publikováno v: ChemMedChem [ChemMedChem] 2021 Jan 19; Vol. 16 (2), pp. 368-376. Date of Electronic Publication: 2020 Oct 16.