Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis

Autor: van Rooij, Frank J.A. ¹, Qayyum, Rehan ², Smith, Albert V. ^{3, 4}, Zhou, Yi ^{5, 6}, Trompet, Stella ^{7, 8}, Tanaka, Toshiko ⁹, Keller, Margaux F. ¹⁰, Chang, Li-Ching ¹¹, Schmidt, Helena ¹², Yang, Min-Lee ¹³, Chen, Ming-Huei ^{14, 15}, Hayes, James ¹⁶, Johnson, Andrew D. ¹⁵, Yanek, Lisa R. ², Mueller, Christian ^{17, 46}, Lange, Leslie ¹⁸, Floyd, James S. ¹⁹, Ghanbari, Mohsen ^{1, 20}, Zonderman, Alan B. ²¹, Jukema, J. Wouter ⁷, Hofman, Albert ^{1, 22}, van Duijn, Cornelia M. ¹, Desch, Karl C. ²³, Saba, Yasaman ¹², Ozel, Ayse B. ²³, Snively, Beverly M. ²⁴, Wu, Jer-Yuarn ^{11, 25}, Schmidt, Reinhold ²⁶, Fornage, Myriam ²⁷, Klein, Robert J. ¹⁶, Fox, Caroline S. ¹⁵, Matsuda, Koichi ²⁸, Kamatani, Naoyuki ²⁹, Wild, Philipp S. ^{30, 31, 32}, Stott, David J. ³³, Ford, Ian ³⁴, Slagboom, P. Eline ³⁵, Yang, Jaden ³⁶, Chu, Audrey Y. ³⁷, Lambert, Amy J. ³⁸, Uitterlinden, André G. ^{1, 39}, Franco, Oscar H. ¹, Hofer, Edith ^{26, 40}, Ginsburg, David ²³, Hu, Bella ^{5, 6}, Keating, Brendan ^{41, 42}, Schick, Ursula M. ^{43, 44}, Brody, Jennifer A. ¹⁹, Li, Jun Z. ²³, Chen, Zhao ⁴⁵, Zeller, Tanja ^{17, 46}, Guralnik, Jack M. ⁴⁷, Chasman, Daniel I. ^{37, 48}, Peters, Luanne L. ³⁸, Kubo, Michiaki ⁴⁹, Becker, Diane M. ², Li, Jin ⁵⁰, Eiriksdottir, Gudny ⁴, Rotter, Jerome I. ⁵¹, Levy, Daniel ¹⁵, Grossmann, Vera ³⁰, Patel, Kushang V. ²¹, Chen, Chien-Hsiun ^{11, 25}, Ridker, Paul M. ^{37, 52}, Tang, Hua ⁵³, Launer, Lenore J. ⁵⁴, Rice, Kenneth M. ⁵⁵, Li-Gao, Ruifang ⁵⁶, Ferrucci, Luigi ⁹, Evans, Michelle K. ⁵⁷, Choudhuri, Avik ^{5, 6}, Trompouki, Eirini ^{6, 58}, Abraham, Brian J. ⁵⁹, Yang, Song ^{5, 6}, Takahashi, Atsushi ²⁹, Kamatani, Yoichiro ²⁹, Kooperberg, Charles ⁶⁰, Harris, Tamara B. ⁵⁴, Jee, Sun Ha ⁶¹, Coresh, Josef ⁶², Tsai, Fuu-Jen ²⁵, Longo, Dan L. ⁶³, Chen, Yuan-Tsong ¹¹, Felix, Janine F. ¹, Yang, Qiong ^{15, 64}, Psaty, Bruce M. ^{65, 66}, Boerwinkle, Eric ²⁷, Becker, Lewis C. ², Mook-Kanamori, Dennis O. ^{56, 67, 68}, Wilson, James G. ⁶⁹, Gudnason, Vilmundur ^{3, 4}, O'Donnell, Christopher J. ¹⁵, Dehghan, Abbas ^{1, 70}, Cupples, L. Adrienne ^{15, 64}, Nalls, Michael A. ¹⁰, Morris, Andrew P. ^{71, 72}, Okada, Yukinori ^{29, 73}, Reiner, Alexander P. ^{43, 74}, Zon, Leonard I. ^{5, 6}, Ganesh, Santhi K. ^{13, ∗}

Publikováno v: In The American Journal of Human Genetics 5 January 2017 100(1):51-63

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XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway.

Autor: Chen, Xi, Iliopoulos, Dimitrios, Zhang, Qing, Tang, Qianzi, Greenblatt, Matthew B., Hatziapostolou, Maria, Lim, Elgene, Tam, Wai Leong, Ni, Min, Chen, Yiwen, Mai, Junhua, Shen, Haifa, Hu, Dorothy Z., Adoro, Stanley, Hu, Bella, Song, Minkyung, Tan, Chen, Landis, Melissa D., Ferrari, Mauro, Shin, Sandra J.

Publikováno v: Nature; 4/ 3/2014, Vol. 508 Issue 7494, p103-107, 5p, 1 Diagram, 13 Graphs

Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits

Autor: Lehtimaki, Terho, Grarup, Niels, Hofman, Albert, Launer, Lenore J., Liewald, David C., Smith, Albert Vernon, Yang, Min-Lee, Di Sant, Amanda M. Rosa, Taylor, Kent D., Pedersen, Oluf, O'Donnell, Christopher J., Tracy, Russell P., Hansen, Torben, Franceschini, Nora, Jia, Jia, Bork-Jensen, Jette, Johnson, Andrew D., Zon, Leonard I., Floyd, James S., Bottinger, Erwin P., Harris, Tamara B., Loos, Ruth J. F., Marioni, Riccardo E., Proia, Richard L., Clavo, Vinna, Deary, Ian J., Reiner, Alex P., Jackson, Rebecca D., Brody, Jennifer A., Ahluwalia, Tarunveer Singh, Starr, John M., Pankratz, Nathan, Allende, Maria Laura, Pazoki, Raha, Hunker, Kristina, Garcia, Melissa E., Hagedorn, Elliott J., Lu, Yingchang, Zhou, Yi, Wilson, James G., Ganesh, Santhi K., Raitakari, Olli T., Cushman, Mary, Rotter, Jerome I., Lyytikainen, Leo-Pekka, Schick, Ursula M., Zhang, Xiaoling, Gudnason, Vilmundur, Linneberg, Allan, Numans, Mattijs E., De Bakker, Paul I. W., Huo, Yong, Dong, Liguang, Zhou, Wei, Thuesen, Betina Heinsbek, Asselbergs, Folkert W., Dehghan, Abbas, Van Rooij, Frank J.A., Kahonen, Mika, Liu, Yongmei, Boerwinkle, Eric, Franco, Oscar H., Nalls, Mike A., Chen, Ming-Huei, Manichaikul, Ani, Nguyen, Vy M., Eicher, John D., Hu, Bella, Wang, Jiansong, Rivadeneira, Fernando, Rich, Stephen S., Uitterlinden, Andre G., Wang, Judy, Grove, Megan L., Psaty, Bruce M., Adrienne Cupples, Feitosa, Mary F., Borecki, Ingrid B., Leusink, Maarten, Auer, Paul L., Zhang, Yan

Hematologic measures such as hematocrit and white blood cell (WBC) count are heritable and clinically relevant. Erythrocyte and WBC phenotypes were analyzed with Illumina HumanExome BeadChip genotypes in 52,531 individuals (37,775 of European ancestr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0bd9bff252afb36241f577ae149a0028