Anti-gametocyte antigen humoral immunity and gametocytemia during treatment of uncomplicated falciparum malaria: a multi-national study

Autor: O'Flaherty, K, Chan, J-A, Cutts, JC, Zaloumis, SG, Ashley, EA, Phyo, AP, Drew, DR, Dondorp, AM, Day, NP, Dhorda, M, Fairhurst, RM, Lim, P, Amaratunga, C, Pukrittayakamee, S, Hien, TT, Htut, Y, Mayxay, M, Faiz, MA, Mokuolu, OA, Onyamboko, MA, Fanello, C, Takashima, E, Tsuboi, T, Theisen, M, Nosten, F, Beeson, JG, Simpson, JA, White, NJ, Fowkes, FJI

Publikováno v: O'Flaherty, K, Chan, J-A, Cutts, J C, Zaloumis, S G, Ashley, E A, Phyo, A P, Drew, D R, Dondorp, A M, Day, N P, Dhorda, M, Fairhurst, R M, Lim, P, Amaratunga, C, Pukrittayakamee, S, Hien, T T, Htut, Y, Mayxay, M, Faiz, M A, Mokuolu, O A, Onyamboko, M A, Fanello, C, Takashima, E, Tsuboi, T, Theisen, M, Nosten, F, Beeson, J G, Simpson, J A, White, N J & Fowkes, F J I 2022, ' Anti-gametocyte antigen humoral immunity and gametocytemia during treatment of uncomplicated falciparum malaria : A multi-national study ', Frontiers in Cellular and Infection Microbiology, vol. 12, pp. 804470 . https://doi.org/10.3389/fcimb.2022.804470
Frontiers in cellular and infection microbiology, 12:804470. Frontiers Media S.A.

IntroductionUnderstanding the human immune response to Plasmodium falciparum gametocytes and its association with gametocytemia is essential for understanding the transmission of malaria as well as progressing transmission blocking vaccine candidates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b599e81209d4db17a225e50112464389
https://ora.ox.ac.uk/objects/uuid:e2116d13-ce4a-47a0-a04e-0e534fd40ede

Host immunity and the assessment of emerging artemisinin resistance in a multinational cohort

Autor: Ataide, R, Ashley, EA, Powell, R, Chan, J-A, Malloy, M, O'Flaherty, K, Takashima, E, Langer, C, Tsuboi, T, Dondorp, AM, Day, NP, Dhorda, M, Fairhurst, RM, Lim, P, Amaratunga, C, Pukrittayakamee, S, Hien, TT, Htut, Y, Mayxay, M, Faiz, MA, Beeson, JG, Nosten, F, Simpson, JA, White, N, Fowkes, FJI

38 Artemisinin-resistant falciparum malaria, defined by a slow-clearance phenotype and the presence of kelch13 mutants, has emerged in the Greater Mekong Subregion. Naturally-acquired immunity to malaria clears parasites independently of antimalarial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6dfc5cd58924f1d22cf79742429b87ca
https://ora.ox.ac.uk/objects/uuid:fa00fb34-2999-4079-80f1-72b9069cdcfa

Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial

Autor: Faiz, MA, Bin Yunus, E, Rahman, MR, Islam, F, Hoque, MG, Hasan, MU, Samad, R, Aung, S, Thein, S, Than, M, Thwe, Y, Ohn, KM, Hla, S, Lwin, S, Htut, Y, Lin, K, Kyaw, MP, Win, N, Aung, WN, Win, M, Oo, AZ, Aung, Z, Shein, OM, Kyi, MM, Myint, WW, Pyar, KP, Nyein, K, Win, KK, Mishra, SK, Mohanty, S, Pattnaik, RB, Acharya, SK, Mohanty, A, Mohapatra, D, Tijtra, E, Anstey, N, Price, R, Handoyo, T, Gampamola, D, Kenangalem, E, Takaendengan, D, Lampat, A, Harijanto, P, Dondorp, AE, Nosten, F, Day, N, Stepniewska, K, Tipmanee, P, Douthwaite, S, Silamut, K, Proux, S, Pongsawat, K, White, N, Grp, SEAQUAMAT

BACKGROUND: In the treatment of severe malaria, intravenous artesunate is more rapidly acting than intravenous quinine in terms of parasite clearance, is safer, and is simpler to administer, but whether it can reduce mortality is uncertain. METHODS:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464f20039518402b2101d49a73916fbd
https://doi.org/10.1016/s0140-6736(05)67176-0

Drug resistance. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance

Autor: Mok, S, Ashley, EA, Ferreira, PE, Zhu, L, Lin, Z, Yeo, T, Chotivanich, K, Imwong, M, Pukrittayakamee, S, Dhorda, M, Nguon, C, Lim, P, Amaratunga, C, Suon, S, Hien, TT, Htut, Y, Faiz, MA, Onyamboko, MA, Mayxay, M, Newton, PN, Tripura, R, Woodrow, CJ, Miotto, O, Kwiatkowski, DP, Nosten, F, Day, NP, Preiser, PR, White, NJ, Dondorp, AM, Fairhurst, RM, Bozdech, Z

Publikováno v: Science (New York, N.Y.). 347(6220)

Artemisinin resistance in Plasmodium falciparum threatens global efforts to control and eliminate malaria. Polymorphisms in the kelch domain-carrying protein K13 are associated with artemisinin resistance, but the underlying molecular mechanisms are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::d7d6d9ffe96b677256479ea2b876d31e
http://ora.ox.ac.uk/objects/uuid:54f8cdb6-8fdf-4f5a-b32b-2cb0b74b7bd9

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