Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Htet A. Khant"'
Autor:
Manish K. Yadav, Ravi Yadav, Parishmita Sarma, Jagannath Maharana, Chahat Soni, Sayantan Saha, Vinay Singh, Manisankar Ganguly, Shirsha Saha, Htet A. Khant, Ramanuj Banerjee, Arun K. Shukla, Cornelius Gati
The complement cascade is an integral part of innate immunity, and it plays a crucial role in our body’s innate immune response including combating microbial infections. Activation of the complement cascade results in the generation of multiple pep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f50f6f8dedefc3d25c765c773108342b
https://doi.org/10.1101/2023.02.09.527835
https://doi.org/10.1101/2023.02.09.527835
Publikováno v:
Nature Protocols. 9:2630-2642
Advances in electron cryo-tomography have provided a new opportunity to visualize the internal 3D structures of a bacterium. An electron microscope equipped with Zernike phase contrast optics produces images with dramatically increased contrast compa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7813c7815c09797829bc951a913a59cf
https://doi.org/10.1038/nprot.2014.176
https://doi.org/10.1038/nprot.2014.176
Autor:
Wei Dai, Ryan H. Rochat, Wah Chiu, Jacqueline Piret, Xiangan Liu, Michael F. Schmid, Desislava Raytcheva, Htet A. Khant, Kuniaki Nagayama, John G. Flanagan, Cameron Haase-Pettingell, Jonathan King, Caroline J. Fu, S. Ludtke
Publikováno v:
Nature
This study reports the first application of Zernike phase contrast (ZPC) electron cryo-tomography to examine cellular processes without the need for labelling or sectioning; the technique is used to visualize the maturation of the cyanophage Syn5 ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d8d70c0159796e2d6232f95ebd0984
http://europepmc.org/articles/PMC3984937
http://europepmc.org/articles/PMC3984937
Autor:
Htet A. Khant, Wah Chiu, Caroline J. Fu, Wayne R. Gombotz, Benjamin W. Dulken, Tae Hee Kim, Suzie H. Pun, Jenelyn Ramos, Christopher W. Mount
Publikováno v:
Molecular Pharmaceutics. 9:135-143
Polymeric micelles formed by the self-assembly of amphiphilic block copolymers can be used to encapsulate hydrophobic drugs for tumor-delivery applications. Filamentous carriers with high aspect ratios offer potential advantages over spherical carrie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc9832252c0ca9ff3d0068c537a0613c
https://doi.org/10.1021/mp200381c
https://doi.org/10.1021/mp200381c
Autor:
Jenelyn Ramos, Matthias Stephan, Anna Bershteyn, Bonnie Huang, Soong Ho Um, Wah Chiu, Mashaal Sohail, James J. Moon, Jessica T. Goodwin, Darrell J. Irvine, Heikyung Suh, Htet A. Khant, Haipeng Liu, Samantha S. Luo
Publikováno v:
Nature materials
Vaccines based on recombinant proteins avoid the toxicity and antivector immunity associated with live vaccine (for example, viral) vectors, but their immunogenicity is poor, particularly for CD8(+) T-cell responses. Synthetic particles carrying anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a087793c485e9c7f55ddcd08d36a35c2
https://doi.org/10.1038/nmat2960
https://doi.org/10.1038/nmat2960
Publikováno v:
Biophysical Journal. 97:164-172
Magainin, a 23-residue antibiotic peptide, interacts directly with the lipid bilayer leading to cell lysis in a strongly concentration-dependent fashion. Utilizing cryo-electron microscopy, we have directly observed magainin interacting with syntheti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::192955253a6159c835d70ec3a7991f2f
https://doi.org/10.1016/j.bpj.2009.04.039
https://doi.org/10.1016/j.bpj.2009.04.039
Autor:
Yao Cong, Matthew T. Dougherty, Qinfen Zhang, David Woolford, Heinz Decker, Thorsten Schweikardt, Wah Chiu, Steven J. Ludtke, Htet A. Khant
Publikováno v:
Structure. 17(5):749-758
Summary Phenoloxidases (POs) occur in all organisms and are involved in skin and hair coloring in mammals, and initiating melanization in wound healing. Mutation or overexpression of PO can cause albinism or melanoma, respectively. SDS can convert in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::978bde995918ffddb6711482f658ab9c
Publikováno v:
Biochemistry. 48:3304-3314
Self-assembly of peptide amphiphiles into nanostructures makes them attractive for a variety of applications in drug and peptide delivery. We here report on the interactions of micelles composed of a palmitoylated, pro-apoptotic peptide derived from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b12411f10385dda4dbb80ecf8e06a85e
https://doi.org/10.1021/bi802356k
https://doi.org/10.1021/bi802356k
Autor:
Mikyung Han, Baiba K. Gillard, Henry J. Pownall, Harry S. Courtney, Steven J. Ludtke, Htet A. Khant, Corina Rosales, Kathryn Ward
Publikováno v:
Biochemistry. 48:1481-1487
Human plasma high-density lipoproteins (HDL), the primary vehicle for reverse cholesterol transport, are the target of serum opacity factor (SOF), a virulence determinant of Streptococcus pyogenes that turns serum opaque. HDL comprise a core of neutr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::043378c35e03be2a1ba7654238019595
https://doi.org/10.1021/bi802287q
https://doi.org/10.1021/bi802287q
Autor:
Thomas C. Südhof, Josep Rizo, Htet A. Khant, Steven J. Ludtke, Demet Araç, Arthur E. Johnson, Josep Ubach, Masahide Kikkawa, Wah Chiu, Xiaocheng Chen
Publikováno v:
Nature Structural & Molecular Biology. 13:209-217
Synaptotagmin acts as a Ca2+ sensor in neurotransmitter release through its two C2 domains. Ca2+-dependent phospholipid binding is key for synaptotagmin function, but it is unclear how this activity cooperates with the SNARE complex involved in relea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0ad858547a9eba2ff18d9d8a70d3b9c
https://doi.org/10.1038/nsmb1056
https://doi.org/10.1038/nsmb1056