Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Hsueh-Ping Chu"'
Publikováno v:
Journal of Biomedical Science, Vol 27, Iss 1, Pp 1-14 (2020)
Abstract Protein and DNA have been considered as the major components of chromatin. But beyond that, an increasing number of studies show that RNA occupies a large amount of chromatin and acts as a regulator of nuclear architecture. A significant fra
Externí odkaz:
https://doaj.org/article/73e484f2e3d84a9f9e89b4736e9331db
Autor:
Ke-Vin Chang, Yu-Chen Chen, Wei-Ting Wu, Hong-Jhin Shen, Kuo-Chin Huang, Hsueh-Ping Chu, Der-Sheng Han
Publikováno v:
Nutrients, Vol 12, Iss 12, p 3766 (2020)
Sarcopenia is defined as aging-related loss of muscle mass and function. Telomere length in chromosomes shortens with age and is modulated by telomeric repeat-containing RNA (TERRA). This study aimed to explore the impact of aging and sarcopenia on t
Externí odkaz:
https://doaj.org/article/9ba43effbc8e4f99b8abf776e520983d
Autor:
Jeannie T. Lee, Yunfei Chen, Robert Morris, Myriam Boukhali, Anand Minajigi, Chia-Yu Guh, Wilhelm Haas, Hsueh-Ping Chu, Yu-Hung Hsieh
Publikováno v:
Nature Protocols. 16:3672-3694
More than 90% of the human genome is transcribed into noncoding RNAs, but their functional characterization has lagged behind. A major bottleneck in the understanding of their functions and mechanisms has been a dearth of systematic methods for ident
Autor:
Barry Kesner, Hyun Jung Oh, Rodrigo Aguilar, Andrea J. Kriz, Hsueh-Ping Chu, Jeannie T. Lee, Hun-Goo Lee
Publikováno v:
Cell. 184(25)
Summary Chromosome loops shift dynamically during development, homeostasis, and disease. CCCTC-binding factor (CTCF) is known to anchor loops and construct 3D genomes, but how anchor sites are selected is not yet understood. Here, we unveil Jpx RNA a
Publikováno v:
Endocrinology. 162(12)
Glucose is a major energy source for growth. At birth, neonates must change their energy source from maternal supply to its own glucose production. The mechanism of this transition has not been clearly elucidated. To evaluate the possible roles of st
Autor:
Hsueh-Ping, Chu, Anand, Minajigi, Yunfei, Chen, Robert, Morris, Chia-Yu, Guh, Yu-Hung, Hsieh, Myriam, Boukhali, Wilhelm, Haas, Jeannie T, Lee
Publikováno v:
Nature protocols. 16(7)
More than 90% of the human genome is transcribed into noncoding RNAs, but their functional characterization has lagged behind. A major bottleneck in the understanding of their functions and mechanisms has been a dearth of systematic methods for ident
Publikováno v:
Journal of Biomedical Science
Journal of Biomedical Science, Vol 27, Iss 1, Pp 1-14 (2020)
Journal of Biomedical Science, Vol 27, Iss 1, Pp 1-14 (2020)
Protein and DNA have been considered as the major components of chromatin. But beyond that, an increasing number of studies show that RNA occupies a large amount of chromatin and acts as a regulator of nuclear architecture. A significant fraction of
Autor:
Stephanie Klosek, Nandakumar Mohan, Kian Parsa, Joyce Kong, Robert Lu, Chia-Yu Guh, Marti Goldenberg, Yun Chen, Beena Biju, Judy Huang, Hsueh-Ping Chu, Hilda A. Pickett, Xiaolei Pan, Naveed Ahmed, Dong Zhang
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Cancer cells maintain their telomeres by either re-activating telomerase or adopting the homologous recombination (HR)-based Alternative Lengthening of Telomere (ALT) pathway. Among the many prominent features of ALT cells, C-circles (CC) formation i
Autor:
Barry Kesner, John E. Froberg, Hyun Jung Oh, Fei Ji, Hsueh-Ping Chu, Ruslan I. Sadreyev, Stefan F. Pinter, Jeannie T. Lee
Publikováno v:
Nature structural & molecular biology
In mammals, homologous chromosomes rarely pair outside meiosis. One exception is the X chromosome, which transiently pairs during X-chromosome inactivation (XCI). How two chromosomes find each other in 3D space is not known. Here, we reveal a require