Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Hsueh-Ping Catherine Chu"'
Autor:
Bing-Ze Yang, Mei-Yin Liu, Kuan-Lin Chiu, Yuh-Ling Chien, Ching-An Cheng, Yu-Lin Chen, Li-Yu Tsui, Keng-Ru Lin, Hsueh-Ping Catherine Chu, Ching-Shyi Peter Wu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract RNA helicase DHX9 is essential for genome stability by resolving aberrant R-loops. However, its regulatory mechanisms remain unclear. Here we show that SUMOylation at lysine 120 (K120) is crucial for DHX9 function. Preventing SUMOylation at
Externí odkaz:
https://doaj.org/article/d20bd17269914d3baa35b3b2dd79b01d
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Chromatin organization and dynamics play important roles in governing the regulation of nuclear processes of biological cells. However, due to the constant diffusive motion of chromatin, examining chromatin nanostructures in living cells has
Externí odkaz:
https://doaj.org/article/4229172f8ec846338651783bd34cfa36
Autor:
Chia-Yu Guh, Hong-Jhih Shen, Liv WeiChien Chen, Pei-Chen Chiu, I-Hsin Liao, Chen-Chia Lo, Yunfei Chen, Yu-Hung Hsieh, Ting-Chia Chang, Chien-Ping Yen, Yi-Yun Chen, Tom Wei-Wu Chen, Liuh-Yow Chen, Ching-Shyi Wu, Jean-Marc Egly, Hsueh-Ping Catherine Chu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Here the authors show TERRA R-loops recruit the endonuclease XPF to telomeres, leading to DNA double-strand breaks to activate break-induced telomere synthesis at telomeres that utilize the alternative lengthening of telomeres (ALT) pathway to extend
Externí odkaz:
https://doaj.org/article/a1fb0e9f73254a64ac93c3ea84dcbcc8
Autor:
Ru-Xuan Tsai, Kuo-Chen Fang, Po-Cheng Yang, Yu-Hung Hsieh, I-Tien Chiang, Yunfei Chen, Hun-Goo Lee, Jeannie T Lee, Hsueh-Ping Catherine Chu
Publikováno v:
Nucleic Acids Research. 50:12217-12234
The genome consists of non-B-DNA structures such as G-quadruplexes (G4) that are involved in the regulation of genome stability and transcription. Telomeric-repeat containing RNA (TERRA) is capable of folding into G-quadruplex and interacting with ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2369d4cae42e31b629a341962adb5fa
https://doi.org/10.1093/nar/gkac1114
https://doi.org/10.1093/nar/gkac1114