In silico identification and biological evaluation of a selective MAP4K4 inhibitor against pancreatic cancer

Autor: Chao-Di Chang, Min-Wu Chao, Hsueh-Yun Lee, Yi-Ting Liu, Huang-Ju Tu, Ssu-Ting Lien, Tony Eight Lin, Tzu-Ying Sung, Shih-Chung Yen, Sing-Han Huang, Kai-Cheng Hsu, Shiow-Lin Pan

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)

Inhibiting a specific target in cancer cells and reducing unwanted side effects has become a promising strategy in pancreatic cancer treatment. MAP4K4 is associated with pancreatic cancer development and correlates with poor clinical outcomes. By pho

Externí odkaz: https://doaj.org/article/eeb87040e05f48b3ad27fb6a79897905

Ring size changes in the development of class I HDAC inhibitors

Autor: Er-Chieh Cho, Chi-Yuan Liu, Di-Wei Tang, Hsueh-Yun Lee

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1386-1400 (2021)

Five pathways involving different ring structures led to generation of fourteen thienylbenzamides (7–20) which display the structure-activity relationships of class I HDAC inhibitors. All the synthesised compounds inhibit HDAC1 and HDAC2 selectivel

Externí odkaz: https://doaj.org/article/d0c4b056f55e42ea84796c11c80521d0

Structure-guided design of anti-cancer ribonucleotide reductase inhibitors

Autor: Tessianna A. Misko, Yi-Ting Liu, Michael E. Harris, Nancy L. Oleinick, John Pink, Hsueh-Yun Lee, Chris G. Dealwis

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 438-450 (2019)

Ribonucleotide reductase (RR) catalyses the rate-limiting step of dNTP synthesis, establishing it as an important cancer target. While RR is traditionally inhibited by nucleoside-based antimetabolites, we recently discovered a naphthyl salicyl acyl h

Externí odkaz: https://doaj.org/article/22676211cb304c0cb316d3ab05a629c9

A Novel Dual HDAC6 and Tubulin Inhibitor, MPT0B451, Displays Anti-tumor Ability in Human Cancer Cells in Vitro and in Vivo

Autor: Yi-Wen Wu, Kai-Cheng Hsu, Hsueh-Yun Lee, Tsui-Chin Huang, Tony E. Lin, Yi-Ling Chen, Ting-Yi Sung, Jing-Ping Liou, Wendy W. Hwang-Verslues, Shiow-Lin Pan, Wei-Chun HuangFu

Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)

The combination cancer therapy is a new strategy to circumvent drug resistance for the treatment of high metastasis and advanced malignancies. Herein, we developed a synthesized compound MPT0B451 that display inhibitory effect against histone deacety

Externí odkaz: https://doaj.org/article/03bd2f8c63574a818d000ac9fd170194

Effect of 3-subsitution of quinolinehydroxamic acids on selectivity of histone deacetylase isoforms

Autor: Mei Chuan Chen, Samir Mehndiratta, Hsueh Yun Lee, Jing Ping Liou, Yuh Hsuan Chao, Mei Jung Lai, Cheng Hsin Lee

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 74-84 (2021)

A series of 3-subsituted quinolinehydroxamic acids has been synthesised and evaluated for their effect on human lung cancer cell line (A549), human colorectal cancer cell line (HCT116) and HDAC isoforms 1, 2, 6, and 8. The results indicated that subs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e9a5413fabde1d3680449630eee5da
http://europepmc.org/articles/PMC7655065