N-Hydroxycinnamide Derivatives of Osthole Ameliorate Hyperglycemia through Activation of AMPK and p38 MAPK

Autor: Wei-Hwa Lee, Hsueh-Hsia Wu, Wei-Jan Huang, Yi-Ning Li, Ren-Jye Lin, Shyr-Yi Lin, Yu-Chih Liang

Publikováno v: Molecules, Vol 20, Iss 3, Pp 4516-4529 (2015)

Our previous studies found that osthole markedly reduced blood glucose levels in both db/db and ob/ob mice. To improve the antidiabetic activity of osthole, a series of N-hydroxycinnamide derivatives of osthole were synthesized, and their hypoglycemi

Externí odkaz: https://doaj.org/article/9bc36e0671424afcbbea3a01dbcddbda

Versatile Protein-A Coated Photoelectric Immunosensors with a Purple-Membrane Monolayer Transducer Fabricated by Affinity-Immobilization on a Graphene-Oxide Complexed Linker and by Shear Flow

Autor: Hsueh-Hsia Wu, Xin-Quan Liao, Xin-Ying Wu, Cheng-De Lin, Kai-Ru Jheng, Hong-Ren Chen, Yong-Yi Wang, Hsiu-Mei Chen

Publikováno v: Sensors, Vol 18, Iss 12, p 4493 (2018)

Bacteriorhodopsin-embedded purple membranes (PM) have been demonstrated to be a sensitive photoelectric transducer for microbial detection. To efficiently prepare versatile BR-based immunosensors with protein A as antibody captures, a large, high-cov

Externí odkaz: https://doaj.org/article/ff9b23a24c5c4059a3743974f5c995c5

Recombinant OmpA protein fragments mediate interleukin-17 regulation to prevent Escherichia coli meningitis

Autor: Chia Chih Chang, Hsueh Hsia Wu, Pei Hsuan Lin, Wen Shyang Hsieh, Yi Yuan Yang

Publikováno v: Journal of Microbiology, Immunology and Infection. 49:843-850

Background Neonates are at a higher risk for bacterial meningitis than children of other age groups. Although the mortality rates have decreased over the past few decades, neonatal meningitis is still a severe disease with high morbidity. For bacteri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4bccb22484253cd14cc07f7a8edc47a
https://doi.org/10.1016/j.jmii.2015.05.019

15,16-Dihydrotanshinone I from the Functional Food Salvia miltiorrhiza Exhibits Anticancer Activity in Human HL-60 Leukemia Cells: in Vitro and in Vivo Studies

Autor: Hsueh Hsia Wu, Yu Chih Liang, Tzu Ho Chen, Jun Jen Liu, Wan Leung

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 16, Iss 8, Pp 19387-19400 (2015)
Volume 16
Issue 8
Pages 19387-19400

15,16-Dihydrotanshinone I (DHTS) is extracted from Salvia miltiorrhiza Bunge which is a functional food in Asia. In this study, we investigated the apoptotic effect of DHTS on the human acute myeloid leukemia (AML) type III HL-60 cell line. We found

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35cccb182ee0b389def30199e07e3a45
http://europepmc.org/articles/PMC4581302

Types and Prevalence of Carbapenem-Resistant Acinetobacter calcoaceticus-Acinetobacter baumannii Complex in Northern Taiwan

Autor: Hsueh Hsia Wu, Nai Yu Wang, Jou An Feng, Wen Shyang Hsieh, Li Chuan Weng

Publikováno v: Antimicrobial Agents and Chemotherapy. 58:201-204

The frequency of the carbapenem-resistant Acinetobacter calcoaceticus-Acinetobacter baumannii (CRACB) complex increases annually in our hospitals. However, the types and prevalence of carbapenemases among isolates still remain unclear. In this study,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813a1fbd18ce29e15d203d46f3574ebc
https://doi.org/10.1128/aac.00779-13