Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Hsu-Yi Sun"'
Autor:
Hsu Yi Sun, Na Sun, Hsing Pang Hsieh, Julakanti Satyanarayana Reddy, Chih Ming Chen, Mohane Selvaraj Coumar
Publikováno v:
Organic Process Research & Development. 25:817-830
Herein, a robust and scalable procedure for the synthesis of multikinase inhibitor BPR1K871 (1, a quinazoline compound bearing a substituted thiazoline side chain), which is a clinical candidate fo...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b2928f4828d6a2cba54c996bc3d199d
https://doi.org/10.1021/acs.oprd.0c00515
https://doi.org/10.1021/acs.oprd.0c00515
Autor:
Sing Yi Wang, Pei Yi Chen, Yung Chang Hsu, Teng Kuang Yeh, Hsu Yi Sun, Chun Hwa Chen, Kai-Chia Yeh, Shu Yu Lin, Su Ying Wu, Hsing Pang Hsieh, Ching Ping Chen, Chiung-Tong Chen, Hui Yi Shiao, Yi Hui Peng, Tzu Wen Lien, Fu Ming Kuo, Yi Yu Ke, Wen-Hsing Lin, Chang Ying Chu, Tsu An Hsu
Publikováno v:
Journal of medicinal chemistry. 62(22)
Epidermal growth factor receptor (EGFR)-targeted therapy in non-small cell lung cancer represents a breakthrough in the field of precision medicine. Previously, we have identified a lead compound, furanopyrimidine 2, which contains a (S)-2-phenylglyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c0a7f2358d5cec8f896161d0fefb55
https://pubmed.ncbi.nlm.nih.gov/31560541
https://pubmed.ncbi.nlm.nih.gov/31560541
Autor:
Weir-Torn Jiaang, John T.A. Hsu, Yi-Yu Ke, Chun Wei Chang, Mohane Selvaraj Coumar, Ya-Hui Chi, Hsing Pang Hsieh, Chang-Ying Chu, Po-Chu Kuo, Chiung-Tong Chen, Chun-Hwa Chen, Hui Yi Shiao, Wen-Hsing Lin, Chin-Ting Huang, Kai-Yen Chang, Hsu-Yi Sun, Yu-Sheng Chao, Ka-Shu Fung, Cheng-Tai Lu
Publikováno v:
Journal of Medicinal Chemistry. 56:5247-5260
Ligand efficiency (LE) and lipophilic efficiency (LipE) are two important indicators of "drug-likeness", which are dependent on the molecule's activity and physicochemical properties. We recently reported a furano-pyrimidine Aurora kinase inhibitor 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35baba9f43aefa6a1b116fd6e9cf034a
https://doi.org/10.1021/jm4006059
https://doi.org/10.1021/jm4006059
Autor:
Mohane Selvaraj Coumar, Hsu Yi Sun, Chih Hsiang Tu, Chun Hwa Chen, Su Ying Wu, Sing Yi Wang, Jian Sung Wu, Prashanth Kumar Amancha, Hui Yi Shiao, Hsing Pang Hsieh, John Tsu An Hsu, Pang Min Liu, Wen-Hsing Lin, Ping-Chiang Lyu, Yu-Sheng Chao, Yi Hui Peng
Publikováno v:
Journal of medicinal chemistry. 56(10)
The Asp-Phe-Gly (DFG) motif plays an important role in the regulation of kinase activity. Structure-based drug design was performed to design compounds able to interact with the DFG motif; epidermal growth factor receptor (EGFR) was selected as an ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e369facc64f0a6345cb7ecec09fc1bff
https://pubmed.ncbi.nlm.nih.gov/23611691
https://pubmed.ncbi.nlm.nih.gov/23611691
Autor:
Chin Yu Lin, Jang Yang Chang, Ching Ping Chen, Chiung-Tong Chen, Ying Jun Chen, Hsing Pang Hsieh, Ching Chuan Kuo, Fu Ming Kuo, Jing Ping Liou, Uan Kang Tan, Su Ying Wu, Hsu Yi Sun, Chang Ying Chu, Yu-Shan Wu, Hsien-Tsung Yao, Yi Kun Chiang, Teng Kuang Yeh, Chia Ling Hsiao, Mohane Selvaraj Coumar, Chi Yen Chang
Publikováno v:
Journal of medicinal chemistry. 52(15)
BPR0L075 (2) is a potential anticancer drug candidate designed from Combretastatin A-4 (1) based on the bioisosterism principle. Metabolites of 2, proposed from in vitro human microsome studies, were synthesized, leading to the identification of meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::537ac34fa49b095db12ac1bad9a25dcd
https://pubmed.ncbi.nlm.nih.gov/19586033
https://pubmed.ncbi.nlm.nih.gov/19586033
Autor:
Yu-Shan Wu, Wei Cheng Chen, Ling Chang, Teng Kuang Yeh, Yu-Sheng Chao, Hsien-Tsung Yao, Hsu Yi Sun, Hsing Pang Hsieh, Shih Jung Lan, Chiung-Tong Chen, Yi-Wei Chang
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 35(7)
Methoxy-3-(3,4,5-trimethoxy-benzoyl)-1H-indole (BPR0L075) is a novel synthetic indole compound with microtubule binding activity. Incubation of BPR0L075 with mouse, rat, dog, and human liver microsomes in the presence of NADPH resulted in the forma-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8250fdc8682faa626a0ea439a1a1a8db
https://pubmed.ncbi.nlm.nih.gov/17403915
https://pubmed.ncbi.nlm.nih.gov/17403915
Autor:
Yu-Shan Wu, Mohane Selvaraj Coumar, Jang-Yang Chang, Hsu-Yi Sun, Fu-Ming Kuo, Ching-Chuan Kuo, Ying-Jun Chen, Chi-Yen Chang, Chia-Ling Hsiao, Jing-Ping Liou, Ching-Ping Chen, Hsien-Tsung Yao, Yi-Kun Chiang, Uan-Kang Tan, Chiung-Tong Chen, Chang-Ying Chu, Su-Ying Wu, Teng-Kuang Yeh, Chin-Yu Lin, Hsing-Pang Hsieh
Publikováno v:
Journal of Medicinal Chemistry; Aug2009, Vol. 52 Issue 15, p4941-4945, 5p