Divergent lineage trajectories and genetic landscapes in human gastric intestinal metaplasia organoids associated with early neoplastic progression.

Autor: Yue SSK; Department of Pathology, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong SAR, China., Tong Y; Department of Pathology, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong SAR, China., Siu HC; Department of Pathology, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong SAR, China., Ho SL; Department of Pathology, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong SAR, China., Law SYK; Department of Surgery, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong SAR, China., Tsui WY; Department of Pathology, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong SAR, China., Chan D; Department of Pathology, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong SAR, China., Huang Y; School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Department of Statistics and Actuarial Science, The University of Hong Kong, Pokfulam, Hong Kong SAR, China., Chan ASY; Department of Pathology, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong SAR, China., Yun SW; Department of Pathology, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong SAR, China., Hui HS; Department of Pathology, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong SAR, China., Choi JE; Department of Pathology, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong SAR, China., Hsu MSS; Department of Pathology, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong SAR, China., Lai FPL; Department of Pathology, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong SAR, China., Chan AS; Department of Pathology, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong SAR, China., Yuen ST; Department of Pathology, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Department of Pathology, St. Paul's Hospital, No. 2, Eastern Hospital Road, Causeway Bay, Hong Kong SAR, China., Clevers H; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center, Uppsalalaan 8, Oncode Institute, Utrecht, The Netherlands., Leung SY; Department of Pathology, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong SAR, China suetyi@hku.hk yanhelen@hku.hk.; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong SAR, China.; The Jockey Club Centre for Clinical Innovation and Discovery, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.; Centre for PanorOmic Sciences, The University of Hong Kong, Pokfulam, Hong Kong SAR, China., Yan HHN; Department of Pathology, School of Clinical Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong SAR, China suetyi@hku.hk yanhelen@hku.hk.; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong SAR, China.

Publikováno v: Gut [Gut] 2024 Nov 20. Date of Electronic Publication: 2024 Nov 20.

Sex Differences in Association Between Gut Microbiome and Essential Hypertension Based on Ambulatory Blood Pressure Monitoring.

Autor: Virwani PD; Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine (P.D.V., M.S.S.H., T.K.K.T.S.P., C.N.-M.C., Y.H.C., L.K.T., Y.-H.T., J.-W.X., S.S.-W.L., C.P.I.L., C.C.W.L., R.K.C.L., T.L.H., B.Y.C., M.-F.Y., I.F.-N.H., K.K.L.)., Qian G; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine (G.Q., J.W.K.H.).; Laboratory of Data Discovery for Health Limited (D4H), Hong Kong Science Park, Hong Kong Special Administrative Region, China (G.Q., J.W.K.H.)., Hsu MSS; Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine (P.D.V., M.S.S.H., T.K.K.T.S.P., C.N.-M.C., Y.H.C., L.K.T., Y.-H.T., J.-W.X., S.S.-W.L., C.P.I.L., C.C.W.L., R.K.C.L., T.L.H., B.Y.C., M.-F.Y., I.F.-N.H., K.K.L.)., Pijarnvanit TKKTS; Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine (P.D.V., M.S.S.H., T.K.K.T.S.P., C.N.-M.C., Y.H.C., L.K.T., Y.-H.T., J.-W.X., S.S.-W.L., C.P.I.L., C.C.W.L., R.K.C.L., T.L.H., B.Y.C., M.-F.Y., I.F.-N.H., K.K.L.)., Cheung CN; Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine (P.D.V., M.S.S.H., T.K.K.T.S.P., C.N.-M.C., Y.H.C., L.K.T., Y.-H.T., J.-W.X., S.S.-W.L., C.P.I.L., C.C.W.L., R.K.C.L., T.L.H., B.Y.C., M.-F.Y., I.F.-N.H., K.K.L.)., Chow YH; Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine (P.D.V., M.S.S.H., T.K.K.T.S.P., C.N.-M.C., Y.H.C., L.K.T., Y.-H.T., J.-W.X., S.S.-W.L., C.P.I.L., C.C.W.L., R.K.C.L., T.L.H., B.Y.C., M.-F.Y., I.F.-N.H., K.K.L.)., Tang LK; Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine (P.D.V., M.S.S.H., T.K.K.T.S.P., C.N.-M.C., Y.H.C., L.K.T., Y.-H.T., J.-W.X., S.S.-W.L., C.P.I.L., C.C.W.L., R.K.C.L., T.L.H., B.Y.C., M.-F.Y., I.F.-N.H., K.K.L.)., Tse YH; Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine (P.D.V., M.S.S.H., T.K.K.T.S.P., C.N.-M.C., Y.H.C., L.K.T., Y.-H.T., J.-W.X., S.S.-W.L., C.P.I.L., C.C.W.L., R.K.C.L., T.L.H., B.Y.C., M.-F.Y., I.F.-N.H., K.K.L.)., Xian JW; Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine (P.D.V., M.S.S.H., T.K.K.T.S.P., C.N.-M.C., Y.H.C., L.K.T., Y.-H.T., J.-W.X., S.S.-W.L., C.P.I.L., C.C.W.L., R.K.C.L., T.L.H., B.Y.C., M.-F.Y., I.F.-N.H., K.K.L.)., Lam SS; Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine (P.D.V., M.S.S.H., T.K.K.T.S.P., C.N.-M.C., Y.H.C., L.K.T., Y.-H.T., J.-W.X., S.S.-W.L., C.P.I.L., C.C.W.L., R.K.C.L., T.L.H., B.Y.C., M.-F.Y., I.F.-N.H., K.K.L.)., Lee CPI; Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine (P.D.V., M.S.S.H., T.K.K.T.S.P., C.N.-M.C., Y.H.C., L.K.T., Y.-H.T., J.-W.X., S.S.-W.L., C.P.I.L., C.C.W.L., R.K.C.L., T.L.H., B.Y.C., M.-F.Y., I.F.-N.H., K.K.L.)., Lo CCW; Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine (P.D.V., M.S.S.H., T.K.K.T.S.P., C.N.-M.C., Y.H.C., L.K.T., Y.-H.T., J.-W.X., S.S.-W.L., C.P.I.L., C.C.W.L., R.K.C.L., T.L.H., B.Y.C., M.-F.Y., I.F.-N.H., K.K.L.)., Liu RKC; Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine (P.D.V., M.S.S.H., T.K.K.T.S.P., C.N.-M.C., Y.H.C., L.K.T., Y.-H.T., J.-W.X., S.S.-W.L., C.P.I.L., C.C.W.L., R.K.C.L., T.L.H., B.Y.C., M.-F.Y., I.F.-N.H., K.K.L.)., Ho TL; Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine (P.D.V., M.S.S.H., T.K.K.T.S.P., C.N.-M.C., Y.H.C., L.K.T., Y.-H.T., J.-W.X., S.S.-W.L., C.P.I.L., C.C.W.L., R.K.C.L., T.L.H., B.Y.C., M.-F.Y., I.F.-N.H., K.K.L.)., Chow BY; Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine (P.D.V., M.S.S.H., T.K.K.T.S.P., C.N.-M.C., Y.H.C., L.K.T., Y.-H.T., J.-W.X., S.S.-W.L., C.P.I.L., C.C.W.L., R.K.C.L., T.L.H., B.Y.C., M.-F.Y., I.F.-N.H., K.K.L.)., Leung KS; School of Biological Sciences, Faculty of Science (K.S.L., E.K.K.L., J.C.Y.L., H.E.-N.)., Tsang HW; Department of Paediatrics and Adolescent Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine (H.W.T., K.T.S.T., P.I.)., Lo EKK; School of Biological Sciences, Faculty of Science (K.S.L., E.K.K.L., J.C.Y.L., H.E.-N.)., Tung KTS; Department of Paediatrics and Adolescent Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine (H.W.T., K.T.S.T., P.I.)., Chung SK; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong Special Administrative Region, China (S.K.C.).; Faculty of Medicine, Dr Neher's Biophysics Laboratory for Innovative Drug DiscoveryState Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau Special Administrative Region, China (S.K.C.)., Yuen MF; Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine (P.D.V., M.S.S.H., T.K.K.T.S.P., C.N.-M.C., Y.H.C., L.K.T., Y.-H.T., J.-W.X., S.S.-W.L., C.P.I.L., C.C.W.L., R.K.C.L., T.L.H., B.Y.C., M.-F.Y., I.F.-N.H., K.K.L.)., Leung SY; Department of Pathology, School of Clinical Medicine, Queen Mary Hospital (S.Y.L.).; The Jockey Club Centre for Clinical Innovation and Discovery, Li Ka Shing Faculty of Medicine (S.Y.L., J.W.K.H.).; Centre for PanorOmic Sciences, Li Ka Shing Faculty of Medicine (S.Y.L., J.W.K.H.)., Ip P; Department of Paediatrics and Adolescent Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine (H.W.T., K.T.S.T., P.I.)., Hung IF; Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine (P.D.V., M.S.S.H., T.K.K.T.S.P., C.N.-M.C., Y.H.C., L.K.T., Y.-H.T., J.-W.X., S.S.-W.L., C.P.I.L., C.C.W.L., R.K.C.L., T.L.H., B.Y.C., M.-F.Y., I.F.-N.H., K.K.L.)., Louie JCY; School of Biological Sciences, Faculty of Science (K.S.L., E.K.K.L., J.C.Y.L., H.E.-N.)., El-Nezami H; School of Biological Sciences, Faculty of Science (K.S.L., E.K.K.L., J.C.Y.L., H.E.-N.).; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio (H.E.-N.)., Ho JWK; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine (G.Q., J.W.K.H.).; The Jockey Club Centre for Clinical Innovation and Discovery, Li Ka Shing Faculty of Medicine (S.Y.L., J.W.K.H.).; Centre for PanorOmic Sciences, Li Ka Shing Faculty of Medicine (S.Y.L., J.W.K.H.).; Laboratory of Data Discovery for Health Limited (D4H), Hong Kong Science Park, Hong Kong Special Administrative Region, China (G.Q., J.W.K.H.)., Lau KK; Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine (P.D.V., M.S.S.H., T.K.K.T.S.P., C.N.-M.C., Y.H.C., L.K.T., Y.-H.T., J.-W.X., S.S.-W.L., C.P.I.L., C.C.W.L., R.K.C.L., T.L.H., B.Y.C., M.-F.Y., I.F.-N.H., K.K.L.).; State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, China (K.K.L.).

Publikováno v: Hypertension (Dallas, Tex. : 1979) [Hypertension] 2023 Jun; Vol. 80 (6), pp. 1331-1342. Date of Electronic Publication: 2023 Apr 19.