Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Hsu Hua Yeh"'
Autor:
Chang Tze Ricky Yu, Li Jen Su, Shih-Lan Hsu, Jin Mei Lai, Wey Jinq Lin, Fen Hwa Wong, Yow-Ling Shiue, Jiunn Chyi Wu, Su Liang Chen, Chi Ying F. Huang, Yong Shiang Lin, Hsu Hua Yeh, Hsiao Sheng Liu
The evolutionarily conserved Aurora family kinases, a family of mitotic serine/threonine kinases, has three members in humans (Aurora-A, -B and -C). Overexpression of Aurora family members, particularly Aurora-A, has been reported in many human cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21c1da3e9914a3072729102231b9627e
https://europepmc.org/articles/PMC6032448/
https://europepmc.org/articles/PMC6032448/
Autor:
Vessela Petrova, Shu-Lin Chang, Hsu-Hua Yeh, Yi-Ming Chiang, Calvin T. Sung, Clay C. C. Wang, Ruth Entwistle, Tzu-Shyang Lin, Green Ahn, Berl R. Oakley, Mike B. Praseuth
Fungal nonribosomal peptide synthetases (NRPSs) are megasynthetases that produce cyclic and acyclic peptides. In Aspergillus nidulans, the NRPS ivoA (AN10576) has been associated with the biosynthesis of grey-brown conidiophore pigments. Another gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::594379094022843cee31e6252849591c
https://europepmc.org/articles/PMC6430764/
https://europepmc.org/articles/PMC6430764/
Autor:
Olivia Yoon, Hsu-Hua Yeh, Berl R. Oakley, Manmeet Ahuja, Heather Hajovsky, Clay C. C. Wang, Shauna Moore, C. Elizabeth Oakley, Jin Woo Bok, Yi-Ming Chiang, Nancy P. Keller
Publikováno v:
ACS chemical biology. 11(8)
Fungal genome projects are revealing thousands of cryptic secondary metabolism (SM) biosynthetic gene clusters that encode pathways that potentially produce valuable compounds. Heterologous expression systems should allow these clusters to be express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3831fb577662be9bd67945eedb985d33
https://pubmed.ncbi.nlm.nih.gov/27294372
https://pubmed.ncbi.nlm.nih.gov/27294372
Autor:
Hsu-Hua Yeh, Shu-Lin Chang, Manmeet Ahuja, Mike B. Praseuth, Hsien-Chun Lo, James F. Sanchez, Ruth Entwistle, Clay C. C. Wang, Berl R. Oakley, Yi-Ming Chiang
Publikováno v:
Journal of the American Chemical Society. 134:8212-8221
Genome sequencing has revealed that fungi have the ability to synthesize many more natural products (NPs) than are currently known, but methods for obtaining suitable expression of NPs have been inadequate. We have developed a successful strategy tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47a5106a701fefe346f15ea0a69cd81d
https://doi.org/10.1021/ja3016395
https://doi.org/10.1021/ja3016395
Publikováno v:
Toxicology and Applied Pharmacology. 219:54-61
We previously found that centaurein enhanced IFN-gamma transcription in T cells. Here, we demonstrate that centaurein increased the IFN-gamma expression in T and NK cells and the serum IFN-gamma level in mice. Centaurein elevated the transcription of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67f308561609125bd638b8b63c0129a6
https://doi.org/10.1016/j.taap.2006.11.026
https://doi.org/10.1016/j.taap.2006.11.026
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:2155-2157
The gliotoxin, a member of the epipolythiodioxopiperazine (ETP), has received considerable attention from the scientific community for its wide range of biological activity. Despite the identification of gliotoxin cluster, however, the sequence of st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::575a6391f4ca97fbca45f5e0c10f29fe
https://doi.org/10.1016/j.bmcl.2013.01.099
https://doi.org/10.1016/j.bmcl.2013.01.099
Publikováno v:
Journal of Biological Chemistry. 279:9875-9881
Histone acetylase and histone deacetylase are two crucial enzymes that determine the structure of chromatin, regulating gene expression. In this study, we observed that trichostatin A (TSA), a specific histone deacetylase inhibitor, could effectively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1372a07d938af6be78ed226f23d5363
https://doi.org/10.1074/jbc.m309884200
https://doi.org/10.1074/jbc.m309884200
Autor:
James F. Sanchez, Yi-Ming Chiang, Chun-Jun Guo, Kenneth S. Bruno, Clay C. C. Wang, Shu-Ling Chang, Hsu-Hua Yeh
Epipolythiodioxopiperazines (ETPs) are a class of fungal secondary metabolites derived from diketopiperazines. Acetylaranotin belongs to one structural subgroup of ETPs characterized by the presence of a seven-membered 4,5-dihydrooxepine ring. Defini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23d116f4fbdf757ed64b32609eadaf22
https://europepmc.org/articles/PMC3695726/
https://europepmc.org/articles/PMC3695726/
Autor:
Yi-Ming Chiang, Clay C. C. Wang, Shu Lin Chang, Hsu Hua Yeh, Kenneth S. Bruno, Berl R. Oakley, Tung-Kung Wu
Publikováno v:
Organic letters. 15(4)
We reannotated the A. niger NR-PKS gene, e_gw1_19.204, and its downstream R domain gene, est_GWPlus_C_190476, as a single gene which we named dtbA. Heterologous expression of dtbA in A. nidulans demonstrated that DtbA protein produces two polyketides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de35a5698561ba145adb9b3e0af5aa06
https://pubmed.ncbi.nlm.nih.gov/23368695
https://pubmed.ncbi.nlm.nih.gov/23368695
Autor:
Yi-Ming Chiang, Kenneth S. Bruno, Hsu Hua Yeh, Kuan Han Lee, Tung-Kung Wu, Ruth Entwistle, Berl R. Oakley, Manmeet Ahuja, Clay C. C. Wang
Publikováno v:
Applied microbiology and biotechnology. 96(3)
Genome sequencing of Aspergillus species including A. nidulans has revealed that there are far more secondary metabolite biosynthetic gene clusters than secondary metabolites isolated from these organisms. This implies that these organisms can produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c553b2086ea72bf6a888fc2aba44a5
https://pubmed.ncbi.nlm.nih.gov/22627757
https://pubmed.ncbi.nlm.nih.gov/22627757