Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Hsp90, heat shock protein 90"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Heat shock protein 90 (Hsp90) is a molecular chaperone important for maintaining protein homeostasis (proteostasis) in the cell. Hsp90 inhibitors are being explored as cancer therapeutics because of their ability to disrupt proteostasis. Inhibiting H
Externí odkaz:
https://doaj.org/article/0afd9a57c5af4e4e990b6abb435b12a6
Autor:
Surya Sukumaran, Mingdian Tan, Shulamit Fluss Ben-Uliel, Hui Zhang, Marta De Zotti, Mei-Sze Chua, Samuel K. So, Nir Qvit
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 3159-3172 (2023)
Heat shock protein 90 (Hsp90) and cell division cycle 37 (Cdc37) work together as a molecular chaperone complex to regulate the activity of a multitude of client protein kinases. These kinases belong to a wide array of intracellular signaling network
Externí odkaz:
https://doaj.org/article/678c69922afe4cac8daf23a7e2dbee8f
Autor:
Hakim Ben Abdallah, Sabine Seeler, Anne Bregnhøj, Gautam Ghatnekar, Lasse S. Kristensen, Lars Iversen, Claus Johansen
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionChronic inflammatory skin diseases may have a profound negative impact on the quality of life. Current treatment options may be inadequate, offering an unsatisfactory response or side effects. Therefore, ongoing efforts exist to identify
Externí odkaz:
https://doaj.org/article/7c72aed23989487c8e622afff88ded0b
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2022)
BackgroundHeat stress (HS) in cattle is a major debilitating problem, affecting health and milk yield. Physiologically, HS has been shown to lower blood glucose levels to 2.5 mmol/l (45 mg/dl) and results in upregulation of heat shock proteins (HSPs)
Externí odkaz:
https://doaj.org/article/65e02fb14ce54724a39ff39dd84be2d9
Akademický článek
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Autor:
Xin Li, Robert S. Hodges, Kenza Mamouni, Hong Yan Liu, Lajos Gera, Rui Zhao, Alira Danaher, Lijuan Bai, Nicholas Cook, Xiaowei Ma, Omer Kucuk, Yang Yang, Daqing Wu
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1261-1274 (2021)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1261-1274 (2021)
A major challenge to the treatment of advanced prostate cancer (PCa) is the development of resistance to androgen-deprivation therapy (ADT) and chemotherapy. It is imperative to discover effective therapies to overcome drug resistance and improve cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a832ce1861512439071b5f1c6c32f2
https://doi.org/10.1016/j.neo.2021.11.006
https://doi.org/10.1016/j.neo.2021.11.006
Akademický článek
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Akademický článek
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Autor:
Mohajershojai, Tabassom, Jha, Preeti, Bostroem, Anna, Frejd, Fredrik Y., Yazaki, Paul J., Nestor, Marika
Carcinoembryonic antigen (CEA) is an antigen that is highly expressed in colorectal cancers and widely used as a tumor marker. I-131 and Y-90-radiolabeled anti-CEA monoclonal antibodies (mAbs) have previously been assessed for radioimmunotherapy in e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6f367b53278b70e676dc8fce85c7b9b4
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-473961
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-473961
Autor:
Shun Shen, Yang Wang, Yongbin Cao, Yao Liu, Huishu Guo, Xiaomin Su, Boshu Ouyang, Zhiqing Pang, Bo Ning
Publikováno v:
Materials Today Bio
Materials Today Bio, Vol 12, Iss, Pp 100154-(2021)
Materials Today Bio, Vol 12, Iss, Pp 100154-(2021)
Ferroptosis has received ever-increasing attention due to its unparalleled mechanism in eliminating resistant tumor cells. Nevertheless, the accumulation of toxic lipid peroxides (LPOs) at the tumor site is limited by the level of lipid oxidation. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a549112f9dd3359da733e0dcf1b6b5cb
https://pubmed.ncbi.nlm.nih.gov/34778741
https://pubmed.ncbi.nlm.nih.gov/34778741